YAL029C / MYO4

Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL029C / MYO4

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.70|P-value:9.08E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.59|P-value:1.41E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.33|P-value:4.04E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.60|P-value:1.36E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.09|P-value:9.43E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.15|P-value:7.65E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.14|P-value:7.46E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.10|P-value:8.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.84E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.89|P-value:4.27E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.42|P-value:3.94E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.32|P-value:3.99E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.34|P-value:3.89E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.87|P-value:4.53E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.99|P-value:2.31E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.70|P-value:9.28E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.56|P-value:2.02E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.79|P-value:6.43E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.63|P-value:1.46E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.92|P-value:3.75E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:4.28E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.45|P-value:2.53E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.21|P-value:6.17E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.70|P-value:9.27E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.26|P-value:4.96E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.76|P-value:7.14E-5 ID:SGTC_1925|Compound:st057770|FD-Score:5.05|P-value:1.64E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.24|P-value:5.26E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.08|P-value:9.29E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.13|P-value:7.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.18|P-value:2.19E-10 ID:SGTC_2795|Compound:7780010|FD-Score:-3.07|P-value:9.85E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.18|P-value:6.80E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.32|P-value:4.07E-4 ID:SGTC_3312|Compound:9133330|FD-Score:4.30|P-value:6.85E-6 ID:SGTC_2|Compound:0422-0095|FD-Score:3.70|P-value:9.08E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.59|P-value:1.41E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.33|P-value:4.04E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.60|P-value:1.36E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.09|P-value:9.43E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.15|P-value:7.65E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.14|P-value:7.46E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.10|P-value:8.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.84E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.89|P-value:4.27E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.42|P-value:3.94E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.32|P-value:3.99E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.34|P-value:3.89E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.87|P-value:4.53E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.99|P-value:2.31E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.70|P-value:9.28E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.56|P-value:2.02E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.79|P-value:6.43E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.63|P-value:1.46E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.92|P-value:3.75E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:4.28E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.45|P-value:2.53E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.21|P-value:6.17E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.70|P-value:9.27E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.26|P-value:4.96E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.76|P-value:7.14E-5 ID:SGTC_1925|Compound:st057770|FD-Score:5.05|P-value:1.64E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.24|P-value:5.26E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.08|P-value:9.29E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.13|P-value:7.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.18|P-value:2.19E-10 ID:SGTC_2795|Compound:7780010|FD-Score:-3.07|P-value:9.85E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.18|P-value:6.80E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.32|P-value:4.07E-4 ID:SGTC_3312|Compound:9133330|FD-Score:4.30|P-value:6.85E-6

Top fitness defect scores for YAL029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.18 100.0 µM 2.19E-10 redox potentiating 149 3.27E-10
2 SGTC_1925 st057770 5.05 10.1 µM 1.64E-7 TSC3-RPN4 6 2.17E-7
3 SGTC_1047 2043-3044 4.99 82.0 µM 2.31E-7 16 3.03E-7
4 SGTC_1179 1021-1431 4.79 9.3 µM 6.43E-7 22 8.27E-7
5 SGTC_1258 0671-0043 4.63 57.1 µM 1.46E-6 11 1.85E-6
6 SGTC_1132 3456-3614 4.56 2.5 µM 2.02E-6 tubulin folding & SWR complex 24 2.55E-6
7 SGTC_646 4092-0839 4.42 27.3 µM 3.94E-6 plasma membrane duress 18 4.91E-6
8 SGTC_3312 9133330 4.30 71.4 µM 6.85E-6 3 8.44E-6
9 SGTC_793 0488-0545 3.96 106.0 µM 3.15E-5 16 3.77E-5
10 SGTC_1365 1672-3266 3.92 55.4 µM 3.75E-5 18 4.48E-5
11 SGTC_617 3770-0098 3.89 35.0 µM 4.27E-5 exosome 16 5.09E-5
12 SGTC_1007 4101-0031 3.87 70.0 µM 4.53E-5 20 5.39E-5
13 SGTC_1820 st053765 3.76 18.6 µM 7.14E-5 RPP1 & pyrimidine depletion 23 8.42E-5
14 SGTC_2 0422-0095 3.70 29.0 µM 9.08E-5 redox potentiating 8 1.07E-4
15 SGTC_1768 st044301 3.70 37.2 µM 9.27E-5 22 1.09E-4
16 SGTC_1120 ficusin 3.70 1.8 µM 9.28E-5 33 1.09E-4
17 SGTC_115 0527-0192 3.60 112.0 µM 1.36E-4 93 1.59E-4
18 SGTC_9 0092-0002 3.59 10.4 µM 1.41E-4 45 1.64E-4
19 SGTC_180 1486-1293 3.48 102.8 µM 2.17E-4 52 2.51E-4
20 SGTC_738 1315-0003 3.47 72.4 µM 2.27E-4 41 2.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 4.69E-24 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.168 1.06E-22 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.165 5.56E-22 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.162 3.03E-21 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.158 4.02E-20 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.156 1.14E-19 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.155 1.48E-19 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.148 6.51E-18 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.146 2.26E-17 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.135 4.77E-15 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.133 1.29E-14 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.127 1.63E-13 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.122 1.36E-12 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.122 1.37E-12 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.121 2.45E-12 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication