YAL031C / GIP4

Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL031C / GIP4

Click on Significant Values for Screen Details ID:SGTC_237|Compound:nikkomycin|FD-Score:3.43|P-value:1.70E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.67|P-value:1.62E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.36|P-value:2.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.31|P-value:2.93E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.28|P-value:3.20E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.25|P-value:4.70E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.85|P-value:2.96E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.30|P-value:2.98E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.20|P-value:4.20E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.54|P-value:1.16E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.21|P-value:4.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.72|P-value:5.24E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.08|P-value:6.85E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.66|P-value:6.38E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.87|P-value:2.91E-5 ID:SGTC_1899|Compound:st063254|FD-Score:5.35|P-value:1.19E-8 ID:SGTC_1912|Compound:st060209|FD-Score:-3.00|P-value:9.04E-4 ID:SGTC_2031|Compound:5180455|FD-Score:4.18|P-value:6.56E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.72|P-value:4.34E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.43|P-value:1.70E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.22|P-value:4.10E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.78|P-value:3.05E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.64|P-value:6.63E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:4.90|P-value:1.63E-7 ID:SGTC_2812|Compound:7970281|FD-Score:3.14|P-value:5.31E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.75|P-value:4.59E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.00|P-value:1.51E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.18|P-value:6.51E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.34|P-value:3.00E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.31|P-value:2.78E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.64|P-value:7.14E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.96|P-value:1.21E-7 ID:SGTC_3311|Compound:9131146|FD-Score:4.71|P-value:4.50E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:3.35E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.43|P-value:1.70E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.67|P-value:1.62E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.36|P-value:2.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.31|P-value:2.93E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.28|P-value:3.20E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.25|P-value:4.70E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.85|P-value:2.96E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.30|P-value:2.98E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.20|P-value:4.20E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.54|P-value:1.16E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.21|P-value:4.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.72|P-value:5.24E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.08|P-value:6.85E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.66|P-value:6.38E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.87|P-value:2.91E-5 ID:SGTC_1899|Compound:st063254|FD-Score:5.35|P-value:1.19E-8 ID:SGTC_1912|Compound:st060209|FD-Score:-3.00|P-value:9.04E-4 ID:SGTC_2031|Compound:5180455|FD-Score:4.18|P-value:6.56E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.72|P-value:4.34E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.43|P-value:1.70E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.22|P-value:4.10E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.78|P-value:3.05E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.50|P-value:1.28E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.64|P-value:6.63E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:4.90|P-value:1.63E-7 ID:SGTC_2812|Compound:7970281|FD-Score:3.14|P-value:5.31E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.75|P-value:4.59E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.00|P-value:1.51E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.18|P-value:6.51E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.34|P-value:3.00E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.31|P-value:2.78E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.64|P-value:7.14E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.96|P-value:1.21E-7 ID:SGTC_3311|Compound:9131146|FD-Score:4.71|P-value:4.50E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:3.35E-5

Top fitness defect scores for YAL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 5.67 406.0 nM 1.62E-9 sphingolipid biosynthesis & PDR1 33 6.94E-9
2 SGTC_1899 st063254 5.35 59.6 µM 1.19E-8 1 4.38E-8
3 SGTC_2739 tacrine 4.90 100.9 µM 1.63E-7 heme requiring 7 4.89E-7
4 SGTC_2366 9070441 4.78 60.6 µM 3.05E-7 14 8.72E-7
5 SGTC_2097 5376186 4.72 200.0 µM 4.34E-7 7 1.21E-6
6 SGTC_3311 9131146 4.71 2.9 µM 4.50E-7 cell wall 90 1.25E-6
7 SGTC_2614 arthonioic acid 4.64 13.4 µM 6.63E-7 12 1.78E-6
8 SGTC_3137 9097352 4.34 49.5 µM 3.00E-6 33 7.19E-6
9 SGTC_752 1896-0090 4.25 130.0 µM 4.70E-6 TSC3-RPN4 13 1.09E-5
10 SGTC_3130 9127414 4.18 49.5 µM 6.51E-6 16 1.47E-5
11 SGTC_2031 5180455 4.18 200.0 µM 6.56E-6 8 1.48E-5
12 SGTC_2920 7982904 4.00 15.8 µM 1.51E-5 22 3.20E-5
13 SGTC_892 0929-0076 3.85 29.0 µM 2.96E-5 TRP & mitochondrial translation 40 5.95E-5
14 SGTC_3316 9136639 3.82 10.6 µM 3.35E-5 15 6.68E-5
15 SGTC_2826 7992541 3.75 19.5 µM 4.59E-5 22 8.93E-5
16 SGTC_1381 2324-0066 3.72 62.1 µM 5.24E-5 37 1.01E-4
17 SGTC_3144 9087057 3.64 49.5 µM 7.14E-5 20 1.34E-4
18 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.50 70.0 µM 1.28E-4 redox potentiating 94 2.30E-4
19 SGTC_2042 p-Dimethylaminoacetophenone 3.44 200.0 µM 1.67E-4 39 2.94E-4
20 SGTC_930 2810-3379 3.44 265.0 µM 1.68E-4 22 2.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.70E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.102 3.00E-9 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.095 3.45E-8 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.094 5.42E-8 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.093 6.30E-8 YBR195C MSI1 hom Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase
0.093 7.29E-8 YER119C-A_d YER119C-A_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
0.087 3.86E-7 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.086 6.04E-7 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.084 1.09E-6 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.084 1.16E-6 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.083 1.30E-6 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.083 1.31E-6 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.082 2.12E-6 YPL181W CTI6 hom Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.079 4.53E-6 YPL141C FRK1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.077 8.26E-6 YFR023W PES4 hom Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication