YAL033W / POP5

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YAL033W / POP5

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.33|P-value:4.25E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:4.31|P-value:7.51E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.83|P-value:6.04E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.16|P-value:6.55E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.30|P-value:4.76E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.85|P-value:5.69E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:3.32|P-value:4.30E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.10|P-value:8.26E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.25|P-value:5.59E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.19|P-value:6.03E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.52|P-value:2.89E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.20|P-value:1.24E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.56|P-value:1.52E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.37|P-value:5.84E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.10|P-value:9.36E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.28|P-value:4.28E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.51|P-value:2.12E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.27|P-value:5.22E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.22|P-value:1.15E-5 ID:SGTC_2259|Compound:7964009|FD-Score:6.79|P-value:4.40E-12 ID:SGTC_2261|Compound:9010538|FD-Score:4.82|P-value:6.27E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.94|P-value:3.80E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.24|P-value:5.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.16|P-value:1.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:3.13|P-value:8.66E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.92|P-value:4.26E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.00|P-value:2.92E-5 ID:SGTC_3305|Compound:9127027|FD-Score:-3.61|P-value:1.23E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.68|P-value:9.20E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.33|P-value:4.25E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:4.31|P-value:7.51E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.83|P-value:6.04E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.16|P-value:6.55E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.30|P-value:4.76E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.85|P-value:5.69E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:3.32|P-value:4.30E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.10|P-value:8.26E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.25|P-value:5.59E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.19|P-value:6.03E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.52|P-value:2.89E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.20|P-value:1.24E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.56|P-value:1.52E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.37|P-value:5.84E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.10|P-value:9.36E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.28|P-value:4.28E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.51|P-value:2.12E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.27|P-value:5.22E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.22|P-value:1.15E-5 ID:SGTC_2259|Compound:7964009|FD-Score:6.79|P-value:4.40E-12 ID:SGTC_2261|Compound:9010538|FD-Score:4.82|P-value:6.27E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.94|P-value:3.80E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.49|P-value:2.35E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.24|P-value:5.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.16|P-value:1.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:3.13|P-value:8.66E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.92|P-value:4.26E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.00|P-value:2.92E-5 ID:SGTC_3305|Compound:9127027|FD-Score:-3.61|P-value:1.23E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.68|P-value:9.20E-5

Top fitness defect scores for YAL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2259 7964009 6.79 200.0 µM 4.40E-12 superoxide 1 5.80E-12 2.00
2 SGTC_2842 9000675 5.16 19.5 µM 1.06E-7 3 1.22E-7 0.02
3 SGTC_2261 9010538 4.82 184.7 µM 6.27E-7 1 7.01E-7 0.46
4 SGTC_1154 4088-0362 4.52 150.0 µM 2.89E-6 3 3.16E-6 0.00
5 SGTC_1550 gossypolone 4.37 36.6 µM 5.84E-6 3 6.34E-6 0.09
6 SGTC_82 0054-0107 4.31 293.8 µM 7.51E-6 3 8.12E-6 0.15
7 SGTC_2050 5263056 4.22 171.0 µM 1.15E-5 fatty acid desaturase (OLE1) 23 1.23E-5 0.11
8 SGTC_1159 4092-0538 4.20 61.2 µM 1.24E-5 2 1.34E-5 0.28
9 SGTC_3299 9121982 4.00 43.1 µM 2.92E-5 7 3.11E-5 0.57
10 SGTC_2409 alverine citrate 3.94 64.0 µM 3.80E-5 13 4.03E-5 0.02
11 SGTC_3141 9094609 3.92 49.5 µM 4.26E-5 iron homeostasis 16 4.51E-5 0.13
12 SGTC_464 bw-b 70c 3.85 158.0 µM 5.69E-5 8 6.01E-5 0.08
13 SGTC_99 0109-0120 3.83 622.8 µM 6.04E-5 6 6.37E-5 0.02
14 SGTC_1926 methyl fluorone black 3.51 53.6 µM 2.12E-4 DNA intercalators 34 2.20E-4 0.06
15 SGTC_2624 nerol 3.49 100.0 µM 2.35E-4 6 2.44E-4 0.04
16 SGTC_1658 st012944 3.37 20.0 µM 3.64E-4 iron homeostasis 12 3.76E-4 0.08
17 SGTC_77 0828-0286 3.33 12.5 µM 4.25E-4 TSC3-RPN4 11 4.38E-4 0.05
18 SGTC_599 1935-0052 3.32 86.5 µM 4.30E-4 8 4.43E-4 0.33
19 SGTC_2646 retinol 3.32 96.8 µM 4.35E-4 8 4.48E-4 0.05
20 SGTC_436 n,n-dimethylsphingosine 3.30 3.3 µM 4.76E-4 7 4.90E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.83E-11 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.104 1.60E-9 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
0.102 2.78E-9 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.101 4.15E-9 YOL056W GPM3 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.099 8.27E-9 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.087 4.61E-7 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.083 1.28E-6 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.083 1.53E-6 YGL258W VEL1 hom Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
0.082 1.92E-6 YKL029C MAE1 hom Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
0.081 2.97E-6 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.080 3.19E-6 YLR183C TOS4 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
0.080 3.32E-6 YBR233W PBP2 hom RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.64E-6 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.077 9.10E-6 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.073 2.03E-5 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments