YAL034C-B_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Heterozygous strain
fixedexpanded
Profile for YAL034C-B / YAL034C-B

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-4.15|P-value:1.59E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.46|P-value:2.55E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.34|P-value:4.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.21|P-value:7.68E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.76|P-value:1.20E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.56|P-value:1.80E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.26|P-value:5.31E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.45|P-value:2.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.49|P-value:2.82E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.31|P-value:5.39E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.16|P-value:9.13E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.36|P-value:6.38E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.92|P-value:5.17E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.21|P-value:6.38E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.24|P-value:2.14E-10 ID:SGTC_1522|Compound:st012842|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.37|P-value:3.60E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.99|P-value:4.01E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.21|P-value:6.44E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.40|P-value:6.77E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:5.09|P-value:2.34E-7 ID:SGTC_1976|Compound:st070609|FD-Score:4.10|P-value:2.48E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.84|P-value:7.39E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.14|P-value:8.05E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:4.79E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.14|P-value:9.72E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:7.13E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.05|P-value:3.08E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.16|P-value:7.56E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.15|P-value:2.04E-5 ID:SGTC_2351|Compound:9026858|FD-Score:5.50|P-value:2.50E-8 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.17|P-value:7.28E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.04|P-value:2.61E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-5.52|P-value:1.69E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-5.98|P-value:1.15E-9 ID:SGTC_2828|Compound:7998861|FD-Score:-3.35|P-value:3.82E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.15|P-value:7.89E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.83|P-value:6.10E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-4.28|P-value:9.18E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-4.72|P-value:1.16E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.49|P-value:2.29E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.15|P-value:7.82E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.27|P-value:5.11E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.11|P-value:9.12E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.15|P-value:1.59E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.46|P-value:2.55E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.34|P-value:4.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.21|P-value:7.68E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.76|P-value:1.20E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.56|P-value:1.80E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.26|P-value:5.31E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.45|P-value:2.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.49|P-value:2.82E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.31|P-value:5.39E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.16|P-value:9.13E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.36|P-value:6.38E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.92|P-value:5.17E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.21|P-value:6.38E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.24|P-value:2.14E-10 ID:SGTC_1522|Compound:st012842|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.37|P-value:3.60E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.99|P-value:4.01E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.21|P-value:6.44E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.40|P-value:6.77E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:5.09|P-value:2.34E-7 ID:SGTC_1976|Compound:st070609|FD-Score:4.10|P-value:2.48E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.84|P-value:7.39E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.14|P-value:8.05E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:4.79E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.14|P-value:9.72E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:7.13E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.05|P-value:3.08E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.16|P-value:7.56E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.15|P-value:2.04E-5 ID:SGTC_2351|Compound:9026858|FD-Score:5.50|P-value:2.50E-8 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.17|P-value:7.28E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.04|P-value:2.61E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-5.52|P-value:1.69E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-5.98|P-value:1.15E-9 ID:SGTC_2828|Compound:7998861|FD-Score:-3.35|P-value:3.82E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.15|P-value:7.89E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.83|P-value:6.10E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-4.28|P-value:9.18E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-4.72|P-value:1.16E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.49|P-value:2.29E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.15|P-value:7.82E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.27|P-value:5.11E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.11|P-value:9.12E-4

Top fitness defect scores for YAL034C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2351 9026858 5.50 72.3 µM 2.50E-8 RNA processing & uracil transport 3 1.90E-8 0.65
2 SGTC_1878 temozolomide 5.09 1.0 mM 2.34E-7 1 1.83E-7 1.03
3 SGTC_422 cantharidin 4.76 155.0 µM 1.20E-6 cell wall signaling 3 9.59E-7 0.03
4 SGTC_1855 st056195 4.40 39.6 µM 6.77E-6 60S ribosome export 7 5.53E-6 0.07
5 SGTC_1070 indatraline 4.24 8.8 µM 1.37E-5 60S ribosome export 3 1.13E-5 0.06
6 SGTC_2350 9023895 4.15 38.9 µM 2.04E-5 ergosterol biosynthesis 6 1.69E-5 0.18
7 SGTC_1976 st070609 4.10 63.5 µM 2.48E-5 2 2.06E-5 0.46
8 SGTC_2338 7999974 4.05 200.0 µM 3.08E-5 7 2.57E-5 0.20
9 SGTC_1601 4'-hydroxyflavanone 3.99 55.5 µM 4.01E-5 RPP1 & pyrimidine depletion 5 3.36E-5 0.01
10 SGTC_1247 0448-0043 3.92 5.8 µM 5.17E-5 ERG2 11 4.34E-5 0.13
11 SGTC_2021 4019055 3.84 173.0 µM 7.39E-5 endomembrane recycling 35 6.24E-5 0.03
12 SGTC_2103 5378138 3.74 10.0 µM 1.07E-4 2 9.12E-5 0.25
13 SGTC_1203 3992-3522 3.61 103.0 µM 1.80E-4 17 1.54E-4 0.02
14 SGTC_536 3852-0578 3.60 10.6 µM 1.88E-4 4 1.61E-4 0.18
15 SGTC_1522 st012842 3.54 45.6 µM 2.34E-4 RNA pol III & RNase P/MRP 16 2.01E-4 0.02
16 SGTC_2568 diosmetin 3.50 100.0 µM 2.68E-4 16 2.31E-4 0.13
17 SGTC_741 4582-0002 3.49 126.0 µM 2.82E-4 5 2.43E-4 0.19
18 SGTC_986 1493-0483 3.44 84.0 µM 3.39E-4 6 2.93E-4 0.06
19 SGTC_348 k064-0012 3.34 10.7 µM 4.75E-4 60S ribosome export 12 4.12E-4 0.12
20 SGTC_2100 5377183 3.34 190.0 µM 4.79E-4 60S ribosome export 16 4.16E-4 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.35E-23 YAL032C PRP45 het Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.119 4.99E-12 YGR264C MES1 het Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
0.100 6.61E-9 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.100 7.29E-9 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.099 8.60E-9 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.097 1.57E-8 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.097 1.58E-8 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.096 2.24E-8 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.092 9.13E-8 YAL003W EFB1 het Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
0.092 9.68E-8 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.091 1.50E-7 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.090 1.76E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.088 3.16E-7 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.085 7.11E-7 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.085 8.05E-7 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress