YAL038W / CDC19

Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YAL038W / CDC19

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.63|P-value:3.31E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.72|P-value:5.14E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.48|P-value:9.09E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.51|P-value:1.43E-7 ID:SGTC_122|Compound:0236-0016|FD-Score:5.16|P-value:7.47E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.34|P-value:2.45E-5 ID:SGTC_252|Compound:miconazole|FD-Score:9.77|P-value:7.67E-20 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.41|P-value:2.31E-7 ID:SGTC_287|Compound:k060-0039|FD-Score:3.51|P-value:5.00E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.00|P-value:9.18E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:5.31|P-value:3.81E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.57|P-value:4.03E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.91|P-value:1.26E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.53|P-value:7.67E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.83|P-value:1.66E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.83|P-value:2.88E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.54|P-value:6.18E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.50|P-value:5.08E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.43|P-value:2.12E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.92|P-value:2.13E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.79|P-value:3.87E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:3.82|P-value:1.75E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.09|P-value:6.51E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:5.59|P-value:9.82E-8 ID:SGTC_807|Compound:1315-0151|FD-Score:4.62|P-value:8.19E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:3.54|P-value:4.48E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.42|P-value:1.81E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.43|P-value:3.30E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.03|P-value:1.46E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.44|P-value:1.69E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.00|P-value:1.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.44|P-value:6.27E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.40|P-value:2.11E-26 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.36|P-value:7.90E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.90|P-value:2.01E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.22|P-value:3.95E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.28|P-value:3.19E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.06|P-value:1.31E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.97|P-value:1.45E-8 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.43|P-value:6.43E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-4.51|P-value:2.37E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.16|P-value:2.02E-14 ID:SGTC_1750|Compound:st081859|FD-Score:5.03|P-value:1.40E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-5.24|P-value:1.10E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-3.85|P-value:2.72E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.79|P-value:3.28E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-4.33|P-value:4.77E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.98|P-value:1.73E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.21|P-value:4.18E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.31|P-value:9.46E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.63|P-value:3.66E-10 ID:SGTC_2290|Compound:7904846|FD-Score:-4.01|P-value:1.54E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.53|P-value:4.59E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.78|P-value:3.81E-8 ID:SGTC_2481|Compound:5478948|FD-Score:6.84|P-value:1.05E-10 ID:SGTC_2482|Compound:5981709|FD-Score:8.21|P-value:1.44E-14 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.61|P-value:1.90E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.40|P-value:1.99E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.66|P-value:3.01E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.21|P-value:4.21E-5 ID:SGTC_2701|Compound:st077767|FD-Score:3.61|P-value:3.53E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.27|P-value:2.78E-9 ID:SGTC_2832|Compound:7992762|FD-Score:3.73|P-value:2.39E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.36|P-value:4.74E-15 ID:SGTC_2931|Compound:9014674|FD-Score:4.17|P-value:4.90E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.01|P-value:8.69E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.73|P-value:2.33E-4 ID:SGTC_3141|Compound:9094609|FD-Score:7.56|P-value:1.15E-12 ID:SGTC_3142|Compound:9086498|FD-Score:4.64|P-value:7.33E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.18|P-value:4.59E-5 ID:SGTC_3219|Compound:9131112|FD-Score:8.22|P-value:1.29E-14 ID:SGTC_3311|Compound:9131146|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_3341|Compound:9147222|FD-Score:5.48|P-value:1.70E-7 ID:SGTC_7|Compound:0192-1582|FD-Score:3.63|P-value:3.31E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.72|P-value:5.14E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.48|P-value:9.09E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.51|P-value:1.43E-7 ID:SGTC_122|Compound:0236-0016|FD-Score:5.16|P-value:7.47E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.34|P-value:2.45E-5 ID:SGTC_252|Compound:miconazole|FD-Score:9.77|P-value:7.67E-20 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.41|P-value:2.31E-7 ID:SGTC_287|Compound:k060-0039|FD-Score:3.51|P-value:5.00E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.00|P-value:9.18E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:5.31|P-value:3.81E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:3.57|P-value:4.03E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.91|P-value:1.26E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.53|P-value:7.67E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.83|P-value:1.66E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.83|P-value:2.88E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.54|P-value:6.18E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.50|P-value:5.08E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.43|P-value:2.12E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.92|P-value:2.13E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.79|P-value:3.87E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:3.82|P-value:1.75E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.09|P-value:6.51E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:5.59|P-value:9.82E-8 ID:SGTC_807|Compound:1315-0151|FD-Score:4.62|P-value:8.19E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:3.54|P-value:4.48E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.42|P-value:1.81E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.43|P-value:3.30E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.03|P-value:1.46E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.44|P-value:1.69E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.00|P-value:1.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.44|P-value:6.27E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.40|P-value:2.11E-26 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.36|P-value:7.90E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.90|P-value:2.01E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.22|P-value:3.95E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.28|P-value:3.19E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.06|P-value:1.31E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.97|P-value:1.45E-8 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.43|P-value:6.43E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-4.51|P-value:2.37E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.16|P-value:2.02E-14 ID:SGTC_1750|Compound:st081859|FD-Score:5.03|P-value:1.40E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-5.24|P-value:1.10E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-3.85|P-value:2.72E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.79|P-value:3.28E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-4.33|P-value:4.77E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.98|P-value:1.73E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.21|P-value:4.18E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.31|P-value:9.46E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.63|P-value:3.66E-10 ID:SGTC_2290|Compound:7904846|FD-Score:-4.01|P-value:1.54E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.53|P-value:4.59E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.78|P-value:3.81E-8 ID:SGTC_2481|Compound:5478948|FD-Score:6.84|P-value:1.05E-10 ID:SGTC_2482|Compound:5981709|FD-Score:8.21|P-value:1.44E-14 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-5.61|P-value:1.90E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.40|P-value:1.99E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.66|P-value:3.01E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.21|P-value:4.21E-5 ID:SGTC_2701|Compound:st077767|FD-Score:3.61|P-value:3.53E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.27|P-value:2.78E-9 ID:SGTC_2832|Compound:7992762|FD-Score:3.73|P-value:2.39E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.36|P-value:4.74E-15 ID:SGTC_2931|Compound:9014674|FD-Score:4.17|P-value:4.90E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.01|P-value:8.69E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.73|P-value:2.33E-4 ID:SGTC_3141|Compound:9094609|FD-Score:7.56|P-value:1.15E-12 ID:SGTC_3142|Compound:9086498|FD-Score:4.64|P-value:7.33E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.18|P-value:4.59E-5 ID:SGTC_3219|Compound:9131112|FD-Score:8.22|P-value:1.29E-14 ID:SGTC_3311|Compound:9131146|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_3341|Compound:9147222|FD-Score:5.48|P-value:1.70E-7

Top fitness defect scores for YAL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1072 oxiconazole 11.40 14.9 nM 2.11E-26 ergosterol depletion effects on membrane 2 1.39E-30 0.17
2 SGTC_252 miconazole 9.77 1.3 nM 7.67E-20 ergosterol depletion effects on membrane 4 7.31E-23 0.33
3 SGTC_2896 9052656 8.36 71.4 µM 4.74E-15 endomembrane recycling 4 3.11E-17 0.50
4 SGTC_3219 9131112 8.22 49.5 µM 1.29E-14 Golgi 3 1.00E-16 0.42
5 SGTC_2482 5981709 8.21 142.7 µM 1.44E-14 PDR1 1 1.14E-16 1.92
6 SGTC_1745 st081495 8.16 74.0 µM 2.02E-14 RNA processing & uracil transport 8 1.70E-16 0.15
7 SGTC_3141 9094609 7.56 49.5 µM 1.15E-12 iron homeostasis 3 1.95E-14 0.37
8 SGTC_2481 5478948 6.84 45.2 µM 1.05E-10 PDR1 2 3.83E-12 0.51
9 SGTC_2249 haloperidol 6.63 116.4 µM 3.66E-10 ergosterol depletion effects on membrane 12 1.66E-11 0.02
10 SGTC_500 h-89 6.54 112.0 µM 6.18E-10 cell wall signaling 2 3.06E-11 1.13
11 SGTC_2778 tioconazole 6.27 65.1 nM 2.78E-9 ergosterol depletion effects on membrane 10 1.77E-10 0.01
12 SGTC_1597 7-benzyloxygramine 5.97 47.5 µM 1.45E-8 calcium & mitochondrial duress 35 1.22E-9 0.01
13 SGTC_1165 k072-0275 5.90 30.3 µM 2.01E-8 3 1.78E-9 1.16
14 SGTC_2351 9026858 5.78 72.3 µM 3.81E-8 RNA processing & uracil transport 1 3.77E-9 0.65
15 SGTC_15 0266-0086 5.72 27.1 µM 5.14E-8 endomembrane recycling 7 5.35E-9 0.50
16 SGTC_786 4544-0069 5.59 423.0 µM 9.82E-8 3 1.14E-8 0.38
17 SGTC_57 miconazole 5.51 162.5 nM 1.43E-7 ergosterol depletion effects on membrane 16 1.76E-8 0.51
18 SGTC_3341 9147222 5.48 25.9 µM 1.70E-7 RNA processing & uracil transport 3 2.15E-8 0.36
19 SGTC_601 0986-0029 5.43 62.9 µM 2.12E-7 calcium & mitochondrial duress 10 2.79E-8 0.48
20 SGTC_256 clotrimazole 5.41 625.0 nM 2.31E-7 ergosterol depletion effects on membrane 10 3.08E-8 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 1.75E-57 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.251 4.11E-49 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.224 3.16E-39 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.223 4.10E-39 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.218 1.92E-37 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.218 2.71E-37 YFL005W SEC4 het Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
0.215 1.78E-36 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.212 2.43E-35 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.210 1.24E-34 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.206 2.81E-33 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.197 1.63E-30 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.190 1.41E-28 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.186 1.94E-27 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.184 8.27E-27 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.176 9.66E-25 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress