HIPHOP chemogenomics database

YAL040C / CLN3

G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis

Zygosity: Homozygous strain

fixedexpanded
Profile for YAL040C / CLN3

Click on Significant Values for Screen Details

Top fitness defect scores for YAL040C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1222	0366-0074	6.77	1.2 µM	1.87E-12	TSC3-RPN4	2	6.65E-12
2	SGTC_1929	genistein trimethyl ether	6.37	50.5 µM	3.00E-11		1	9.25E-11
3	SGTC_675	1309-0189	5.33	238.0 µM	2.18E-8		2	4.78E-8
4	SGTC_2326	6164455	5.32	177.6 µM	2.33E-8	mitochondrial processes	5	5.10E-8
5	SGTC_589	1227-0070	5.31	34.1 µM	2.55E-8		15	5.55E-8
6	SGTC_1157	4092-0394	5.30	27.6 µM	2.66E-8		10	5.79E-8
7	SGTC_2336	9001819	4.95	198.7 µM	1.91E-7	heme biosynthesis & mitochondrial translocase	22	3.75E-7
8	SGTC_2975	9084847	4.68	53.7 µM	8.00E-7		9	1.46E-6
9	SGTC_1545	lovastatin	4.67	49.4 µM	8.24E-7		11	1.51E-6
10	SGTC_1103	duloxetine	4.56	36.1 µM	1.46E-6		14	2.59E-6
11	SGTC_2453	5731132	4.53	22.2 µM	1.64E-6		11	2.90E-6
12	SGTC_1386	3228-0095	4.52	33.8 µM	1.74E-6		12	3.06E-6
13	SGTC_208	k072-0098	4.36	12.4 µM	3.81E-6	heme biosynthesis & mitochondrial translocase	33	6.46E-6
14	SGTC_552	k242-0005	4.33	476.0 µM	4.43E-6		9	7.45E-6
15	SGTC_2640	pentamidine	4.23	10.4 µM	7.07E-6	mitochondrial processes	25	1.16E-5
16	SGTC_1417	3966-0327	4.10	90.4 µM	1.31E-5		14	2.08E-5
17	SGTC_1670	st016595	4.07	4.0 µM	1.45E-5		10	2.30E-5
18	SGTC_157	1348-1695	4.04	65.8 µM	1.72E-5	iron homeostasis	69	2.70E-5
19	SGTC_614	0462-0418	4.01	107.0 µM	1.91E-5		26	2.98E-5
20	SGTC_2995	9067767	3.96	71.4 µM	2.42E-5		20	3.74E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.100	7.38E-9	YEL065W	SIT1	hom	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.087	5.09E-7	YMR309C	NIP1	het	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
0.082	1.89E-6	YOL031C	SIL1	hom	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.082	1.89E-6	YHR203C	RPS4B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.078	6.85E-6	YPL009C	TAE2	hom	Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.076	9.51E-6	YNL299W	TRF5	hom	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.075	1.38E-5	YGR271W	SLH1	hom	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
0.074	1.61E-5	YJL031C	BET4	het	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.074	1.65E-5	YOR296W_p	YOR296W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.074	2.02E-5	YNL312W	RFA2	het	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.073	2.52E-5	YDR010C_d	YDR010C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.071	4.21E-5	YJR082C	EAF6	hom	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.070	5.24E-5	YDL205C	HEM3	het	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.070	5.42E-5	YEL067C_p	YEL067C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070	5.44E-5	YPR186C	PZF1	het	Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA