YAL040C / CLN3

G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL040C / CLN3

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:3.70|P-value:7.30E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-5.50|P-value:7.59E-9 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.32|P-value:3.13E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.08|P-value:7.46E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.24|P-value:4.25E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.36|P-value:3.81E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.86|P-value:3.81E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:9.95E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.65|P-value:8.90E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:9.99E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.33|P-value:4.43E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.12|P-value:6.53E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.39|P-value:2.57E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.31|P-value:2.55E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:4.01|P-value:1.91E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:5.33|P-value:2.18E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.07|P-value:7.81E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.91|P-value:3.04E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.10|P-value:6.88E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.56|P-value:1.46E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.30|P-value:2.66E-8 ID:SGTC_1216|Compound:1165-0504|FD-Score:-4.74|P-value:5.14E-7 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.54|P-value:1.30E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:6.77|P-value:1.87E-12 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.73|P-value:5.99E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.05|P-value:8.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.26|P-value:4.12E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.12|P-value:7.02E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.52|P-value:1.74E-6 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.10|P-value:1.31E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.67|P-value:8.24E-7 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1881|Compound:5652484|FD-Score:-3.22|P-value:4.52E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.95|P-value:2.53E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.11|P-value:7.13E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:6.37|P-value:3.00E-11 ID:SGTC_1970|Compound:st070122|FD-Score:3.08|P-value:8.01E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.90|P-value:3.11E-5 ID:SGTC_2326|Compound:6164455|FD-Score:5.32|P-value:2.33E-8 ID:SGTC_2336|Compound:9001819|FD-Score:4.95|P-value:1.91E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.02|P-value:9.68E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.53|P-value:1.64E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.28|P-value:3.90E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.22|P-value:4.89E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.14|P-value:6.32E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.23|P-value:7.07E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.05|P-value:8.28E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.43|P-value:2.03E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.09|P-value:7.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.68|P-value:8.00E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.96|P-value:2.42E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.12|P-value:6.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.08|P-value:8.02E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.40|P-value:2.31E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.70|P-value:7.30E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-5.50|P-value:7.59E-9 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.32|P-value:3.13E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.08|P-value:7.46E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.24|P-value:4.25E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.36|P-value:3.81E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.86|P-value:3.81E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:9.95E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.65|P-value:8.90E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:9.99E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.33|P-value:4.43E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.12|P-value:6.53E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.39|P-value:2.57E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.31|P-value:2.55E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:4.01|P-value:1.91E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:5.33|P-value:2.18E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.07|P-value:7.81E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.91|P-value:3.04E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.10|P-value:6.88E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.56|P-value:1.46E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.30|P-value:2.66E-8 ID:SGTC_1216|Compound:1165-0504|FD-Score:-4.74|P-value:5.14E-7 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.54|P-value:1.30E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:6.77|P-value:1.87E-12 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.73|P-value:5.99E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.05|P-value:8.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.26|P-value:4.12E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.12|P-value:7.02E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.52|P-value:1.74E-6 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.10|P-value:1.31E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.67|P-value:8.24E-7 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1881|Compound:5652484|FD-Score:-3.22|P-value:4.52E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.95|P-value:2.53E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.11|P-value:7.13E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:6.37|P-value:3.00E-11 ID:SGTC_1970|Compound:st070122|FD-Score:3.08|P-value:8.01E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.90|P-value:3.11E-5 ID:SGTC_2326|Compound:6164455|FD-Score:5.32|P-value:2.33E-8 ID:SGTC_2336|Compound:9001819|FD-Score:4.95|P-value:1.91E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.02|P-value:9.68E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.53|P-value:1.64E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.28|P-value:3.90E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.22|P-value:4.89E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.14|P-value:6.32E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.23|P-value:7.07E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.05|P-value:8.28E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.43|P-value:2.03E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.09|P-value:7.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.68|P-value:8.00E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.96|P-value:2.42E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.12|P-value:6.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.08|P-value:8.02E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.40|P-value:2.31E-4

Top fitness defect scores for YAL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1222 0366-0074 6.77 1.2 µM 1.87E-12 TSC3-RPN4 2 6.65E-12
2 SGTC_1929 genistein trimethyl ether 6.37 50.5 µM 3.00E-11 1 9.25E-11
3 SGTC_675 1309-0189 5.33 238.0 µM 2.18E-8 2 4.78E-8
4 SGTC_2326 6164455 5.32 177.6 µM 2.33E-8 mitochondrial processes 5 5.10E-8
5 SGTC_589 1227-0070 5.31 34.1 µM 2.55E-8 15 5.55E-8
6 SGTC_1157 4092-0394 5.30 27.6 µM 2.66E-8 10 5.79E-8
7 SGTC_2336 9001819 4.95 198.7 µM 1.91E-7 heme biosynthesis & mitochondrial translocase 22 3.75E-7
8 SGTC_2975 9084847 4.68 53.7 µM 8.00E-7 9 1.46E-6
9 SGTC_1545 lovastatin 4.67 49.4 µM 8.24E-7 11 1.51E-6
10 SGTC_1103 duloxetine 4.56 36.1 µM 1.46E-6 14 2.59E-6
11 SGTC_2453 5731132 4.53 22.2 µM 1.64E-6 11 2.90E-6
12 SGTC_1386 3228-0095 4.52 33.8 µM 1.74E-6 12 3.06E-6
13 SGTC_208 k072-0098 4.36 12.4 µM 3.81E-6 heme biosynthesis & mitochondrial translocase 33 6.46E-6
14 SGTC_552 k242-0005 4.33 476.0 µM 4.43E-6 9 7.45E-6
15 SGTC_2640 pentamidine 4.23 10.4 µM 7.07E-6 mitochondrial processes 25 1.16E-5
16 SGTC_1417 3966-0327 4.10 90.4 µM 1.31E-5 14 2.08E-5
17 SGTC_1670 st016595 4.07 4.0 µM 1.45E-5 10 2.30E-5
18 SGTC_157 1348-1695 4.04 65.8 µM 1.72E-5 iron homeostasis 69 2.70E-5
19 SGTC_614 0462-0418 4.01 107.0 µM 1.91E-5 26 2.98E-5
20 SGTC_2995 9067767 3.96 71.4 µM 2.42E-5 20 3.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 7.38E-9 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.087 5.09E-7 YMR309C NIP1 het eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
0.082 1.89E-6 YOL031C SIL1 hom Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.082 1.89E-6 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.078 6.85E-6 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.076 9.51E-6 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.075 1.38E-5 YGR271W SLH1 hom Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
0.074 1.61E-5 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.074 1.65E-5 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.074 2.02E-5 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.073 2.52E-5 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.071 4.21E-5 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.070 5.24E-5 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.070 5.42E-5 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070 5.44E-5 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA