HIPHOP chemogenomics database

YAL041W / CDC24

Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain

fixedexpanded
Profile for YAL041W / CDC24

Click on Significant Values for Screen Details

Top fitness defect scores for YAL041W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_605	1315-0399	6.47	119.0 µM	6.09E-10	Golgi	2	5.00E-11	1.27
2	SGTC_1525	8-methoxypsoralen	6.16	92.5 µM	3.51E-9	DNA damage response	5	3.60E-10	0.99
3	SGTC_589	1227-0070	5.83	34.1 µM	2.20E-8		3	2.85E-9	0.31
4	SGTC_2277	7947813	5.74	106.9 µM	3.45E-8	RSC complex & mRNA processing	7	4.73E-9	0.08
5	SGTC_738	1315-0003	5.74	72.4 µM	3.49E-8		1	4.79E-9	0.55
6	SGTC_2622	2-methoxyxanthone	4.97	59.9 µM	1.48E-6		1	3.27E-7	0.89
7	SGTC_747	3448-8087	4.93	38.7 µM	1.78E-6		3	4.01E-7	0.02
8	SGTC_2229	7354935	4.89	190.0 µM	2.18E-6	RSC complex & mRNA processing	16	5.03E-7	0.95
9	SGTC_1374	2889-5571	4.83	141.0 µM	2.87E-6	RSC complex & mRNA processing	30	6.87E-7	0.01
10	SGTC_2698	st077697	4.70	67.5 µM	5.17E-6		4	1.33E-6	0.41
11	SGTC_934	2950-0684	4.58	338.0 µM	8.59E-6		2	2.36E-6	0.60
12	SGTC_2612	dictamnine	4.51	15.5 µM	1.15E-5	RNA pol III & RNase P/MRP	22	3.26E-6	0.03
13	SGTC_2041	5107442	4.45	45.3 µM	1.49E-5	RSC complex & mRNA processing	22	4.39E-6	0.01
14	SGTC_1608	st001473	4.36	40.5 µM	2.11E-5		2	6.47E-6	0.32
15	SGTC_93	0109-0045	4.31	59.2 µM	2.64E-5	DNA damage response	19	8.34E-6	0.04
16	SGTC_2472	5377652	4.28	49.4 µM	2.93E-5	TRP & mitochondrial translation	7	9.37E-6	0.18
17	SGTC_2128	5255449	4.22	168.5 µM	3.67E-5		6	1.21E-5	0.38
18	SGTC_1155	4088-0394	4.17	48.2 µM	4.44E-5		3	1.49E-5	0.25
19	SGTC_2286	7945697	4.17	125.0 µM	4.51E-5		9	1.52E-5	0.19
20	SGTC_1873	rapamycin	4.12	2.0 nM	5.58E-5		16	1.93E-5	0.14

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.136	2.53E-15	YDR404C	RPB7	het	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.116	1.38E-11	YML130C	ERO1	het	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.097	1.76E-8	YJL081C	ARP4	het	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.090	1.60E-7	YER165W	PAB1	het	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.086	5.77E-7	YMR033W	ARP9	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.083	1.30E-6	YDR172W	SUP35	het	Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.082	2.13E-6	YBL026W	LSM2	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.082	2.22E-6	YFL002C	SPB4	het	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.080	3.41E-6	YML127W	RSC9	het	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.079	4.78E-6	YJL004C	SYS1	hom	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.078	5.44E-6	YPR034W	ARP7	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.077	9.03E-6	YML031W	NDC1	het	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.076	1.01E-5	YGR265W_d	YGR265W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
0.076	1.08E-5	YFR051C	RET2	het	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.076	1.12E-5	YHR143W-A	RPC10	het	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress