YAL042W / ERV46

Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL042W / ERV46

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.49|P-value:1.04E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:3.79E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.64|P-value:2.75E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.22|P-value:3.11E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.35|P-value:7.03E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.36|P-value:6.78E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.60|P-value:3.16E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.54|P-value:8.33E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:3.87|P-value:1.20E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.59|P-value:3.33E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.34|P-value:7.82E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.43|P-value:5.69E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.33|P-value:1.97E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.89|P-value:1.74E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.51|P-value:4.10E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.48|P-value:4.47E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.32|P-value:7.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.69|P-value:2.36E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.15|P-value:4.14E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.41|P-value:6.23E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.38|P-value:6.86E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-4.70|P-value:3.73E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.35|P-value:7.61E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.42|P-value:5.95E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.83|P-value:1.29E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.20|P-value:3.43E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.86|P-value:1.27E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.37|P-value:6.57E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.76|P-value:2.28E-8 ID:SGTC_2085|Compound:5307070|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.88|P-value:1.86E-6 ID:SGTC_2218|Compound:6965428|FD-Score:-3.77|P-value:1.66E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.53|P-value:7.83E-8 ID:SGTC_2298|Compound:7976326|FD-Score:4.01|P-value:7.09E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.92|P-value:9.39E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.30|P-value:2.26E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_2623|Compound:humulene|FD-Score:7.18|P-value:4.73E-12 ID:SGTC_2624|Compound:nerol|FD-Score:-3.34|P-value:7.24E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.79|P-value:2.79E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-4.23|P-value:2.82E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.28|P-value:8.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.27|P-value:9.22E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.21|P-value:1.90E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:4.49|P-value:1.04E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:3.79E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.64|P-value:2.75E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.22|P-value:3.11E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.35|P-value:7.03E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.36|P-value:6.78E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.60|P-value:3.16E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.54|P-value:8.33E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:3.87|P-value:1.20E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.59|P-value:3.33E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.34|P-value:7.82E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.43|P-value:5.69E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.33|P-value:1.97E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.89|P-value:1.74E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.51|P-value:4.10E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.48|P-value:4.47E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.32|P-value:7.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.69|P-value:2.36E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.15|P-value:4.14E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.41|P-value:6.23E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.38|P-value:6.86E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-4.70|P-value:3.73E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.35|P-value:7.61E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.42|P-value:5.95E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.83|P-value:1.29E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.20|P-value:3.43E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.86|P-value:1.27E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.37|P-value:6.57E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.76|P-value:2.28E-8 ID:SGTC_2085|Compound:5307070|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.88|P-value:1.86E-6 ID:SGTC_2218|Compound:6965428|FD-Score:-3.77|P-value:1.66E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.53|P-value:7.83E-8 ID:SGTC_2298|Compound:7976326|FD-Score:4.01|P-value:7.09E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.92|P-value:9.39E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.30|P-value:2.26E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_2623|Compound:humulene|FD-Score:7.18|P-value:4.73E-12 ID:SGTC_2624|Compound:nerol|FD-Score:-3.34|P-value:7.24E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.79|P-value:2.79E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-4.23|P-value:2.82E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.28|P-value:8.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.27|P-value:9.22E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.21|P-value:1.90E-9

Top fitness defect scores for YAL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2623 humulene 7.18 100.0 µM 4.73E-12 1 3.53E-13
2 SGTC_3210 9128157 6.21 49.5 µM 1.90E-9 13 2.67E-10
3 SGTC_2003 4023581 5.76 200.0 µM 2.28E-8 cell wall signaling 15 4.17E-9
4 SGTC_2292 7671323 5.53 168.1 µM 7.83E-8 RNA processing & uracil transport 11 1.63E-8
5 SGTC_562 3772-2733 4.89 112.0 µM 1.74E-6 ERG2 54 5.00E-7
6 SGTC_2156 5649887 4.88 115.0 µM 1.86E-6 RPP1 & pyrimidine depletion 2 5.40E-7
7 SGTC_2688 kanamycin b 4.79 96.7 µM 2.79E-6 calcium & mitochondrial duress 268 8.43E-7
8 SGTC_244 nsc-207895 4.54 1.3 µM 8.33E-6 DNA damage response 13 2.82E-6
9 SGTC_16 erodoxin 4.49 22.8 µM 1.04E-5 unfolded protein response 45 3.60E-6
10 SGTC_542 3381-0244 4.33 89.3 µM 1.97E-5 29 7.32E-6
11 SGTC_126 0417-1624 4.22 672.5 µM 3.11E-5 DNA intercalators 22 1.21E-5
12 SGTC_1824 st053723 4.20 68.6 µM 3.43E-5 25 1.34E-5
13 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.15 1.2 µM 4.14E-5 iron homeostasis 37 1.66E-5
14 SGTC_2298 7976326 4.01 193.8 µM 7.09E-5 9 3.00E-5
15 SGTC_259 usnic acid 3.87 108.9 µM 1.20E-4 20 5.37E-5
16 SGTC_783 0848-0141 3.86 92.7 µM 1.25E-4 RSC & ERG11 17 5.60E-5
17 SGTC_1926 methyl fluorone black 3.86 53.6 µM 1.27E-4 DNA intercalators 66 5.70E-5
18 SGTC_997 3996-0078 3.85 137.0 µM 1.30E-4 25 5.85E-5
19 SGTC_660 4031-1742 3.85 102.0 µM 1.31E-4 redox potentiating 50 5.89E-5
20 SGTC_2501 sodium tetradecyl sulfate 3.82 13.4 µM 1.45E-4 34 6.60E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.51E-15 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.104 1.38E-9 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.099 8.28E-9 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.097 1.81E-8 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.092 8.46E-8 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.092 1.08E-7 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.089 2.22E-7 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.087 4.84E-7 YEL043W YEL043W hom Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
0.086 5.90E-7 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.081 2.89E-6 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.081 3.03E-6 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.080 3.73E-6 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.079 4.97E-6 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.078 5.46E-6 YCL051W LRE1 hom Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
0.078 5.46E-6 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin