YAL044W-A_p

Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL044W-A / YAL044W-A

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.46|P-value:7.39E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.76|P-value:9.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.98|P-value:1.10E-11 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.05|P-value:4.13E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.43|P-value:5.53E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.93|P-value:6.77E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.73|P-value:1.40E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.30|P-value:6.80E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:3.99|P-value:3.60E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.32|P-value:1.39E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.51|P-value:2.09E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.14|P-value:1.71E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.95|P-value:6.15E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.66|P-value:1.15E-10 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.85|P-value:6.46E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.05|P-value:2.88E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.00|P-value:5.08E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.59|P-value:2.75E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.98|P-value:3.87E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.25|P-value:9.09E-7 ID:SGTC_1602|Compound:st001878|FD-Score:3.54|P-value:3.45E-5 ID:SGTC_1735|Compound:st034310|FD-Score:2.91|P-value:5.23E-4 ID:SGTC_1893|Compound:st059353|FD-Score:2.81|P-value:7.52E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.10|P-value:3.41E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.23|P-value:1.39E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-2.86|P-value:8.79E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.56|P-value:1.51E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:1.68E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.79|P-value:8.30E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:9.89E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.98|P-value:5.62E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.88|P-value:6.51E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.46|P-value:7.39E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.76|P-value:9.02E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.98|P-value:1.10E-11 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.05|P-value:4.13E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.43|P-value:5.53E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.93|P-value:6.77E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.73|P-value:1.40E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.30|P-value:6.80E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:3.99|P-value:3.60E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.32|P-value:1.39E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.51|P-value:2.09E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.14|P-value:1.71E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.95|P-value:6.15E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.66|P-value:1.15E-10 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.85|P-value:6.46E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.05|P-value:2.88E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.00|P-value:5.08E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.59|P-value:2.75E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.98|P-value:3.87E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.25|P-value:9.09E-7 ID:SGTC_1602|Compound:st001878|FD-Score:3.54|P-value:3.45E-5 ID:SGTC_1735|Compound:st034310|FD-Score:2.91|P-value:5.23E-4 ID:SGTC_1893|Compound:st059353|FD-Score:2.81|P-value:7.52E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.10|P-value:3.41E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.23|P-value:1.39E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-2.86|P-value:8.79E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.56|P-value:1.51E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:1.68E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.79|P-value:8.30E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:9.89E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.98|P-value:5.62E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.88|P-value:6.51E-6

Top fitness defect scores for YAL044W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 5.98 5.3 µM 1.10E-11 294 1.13E-9
2 SGTC_1070 indatraline 5.66 8.8 µM 1.15E-10 60S ribosome export 6 7.54E-9
3 SGTC_2127 5253358 4.56 187.9 µM 1.51E-7 15 2.50E-6
4 SGTC_1008 4106-0037 4.51 6.0 µM 2.09E-7 PDR1 14 3.24E-6
5 SGTC_789 1309-1135 4.30 70.6 µM 6.80E-7 ERG2 20 8.43E-6
6 SGTC_1525 8-methoxypsoralen 4.25 92.5 µM 9.09E-7 DNA damage response 21 1.07E-5
7 SGTC_1024 4507-0395 4.14 26.0 µM 1.71E-6 TSC3-RPN4 22 1.77E-5
8 SGTC_861 0443-0273 3.99 110.0 µM 3.60E-6 9 3.24E-5
9 SGTC_3269 9137823 3.88 49.5 µM 6.51E-6 60S ribosome export 18 5.24E-5
10 SGTC_2133 5320837 3.80 200.0 µM 9.89E-6 ERG2 29 7.36E-5
11 SGTC_559 1550-0661 3.73 158.0 µM 1.40E-5 9 9.76E-5
12 SGTC_1446 4239-0190 3.59 62.0 µM 2.75E-5 51 1.69E-4
13 SGTC_1602 st001878 3.54 87.6 µM 3.45E-5 26 2.03E-4
14 SGTC_424 splitomicin 3.43 100.0 mM 5.53E-5 36 2.97E-4
15 SGTC_1195 1502-0147 3.26 41.1 µM 1.19E-4 54 5.51E-4
16 SGTC_2065 5221596 3.23 34.3 µM 1.39E-4 38 6.26E-4
17 SGTC_2129 girgensonine 3.18 121.0 µM 1.68E-4 heme biosynthesis & mitochondrial translocase 72 7.29E-4
18 SGTC_1089 terbinafine 3.05 2.2 µM 2.88E-4 47 0.00113
19 SGTC_1495 4469-0029 2.98 237.0 µM 3.87E-4 186 0.00144
20 SGTC_1735 st034310 2.91 56.8 µM 5.23E-4 Golgi 73 0.00183

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 4.41E-50 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.250 3.70E-49 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.242 8.32E-46 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.241 1.36E-45 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.237 4.31E-44 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.234 7.40E-43 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.226 3.88E-40 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.226 6.10E-40 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.225 1.04E-39 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.219 8.70E-38 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.215 3.31E-36 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.214 3.40E-36 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.212 1.47E-35 YLL018C-A COX19 hom Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.212 1.55E-35 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.209 2.57E-34 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase