YAL047C / SPC72

Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL047C / SPC72

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.80|P-value:9.39E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.38|P-value:4.62E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.64|P-value:1.79E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.18|P-value:9.05E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.70|P-value:1.93E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.83|P-value:1.04E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.60|P-value:3.16E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.21|P-value:1.77E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.02|P-value:3.64E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.12|P-value:1.28E-19 ID:SGTC_376|Compound:3970-0862|FD-Score:4.70|P-value:1.99E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:4.90|P-value:7.23E-7 ID:SGTC_397|Compound:arbidol|FD-Score:-3.51|P-value:2.60E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.35|P-value:5.01E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.29|P-value:6.15E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.33|P-value:5.33E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.43|P-value:3.84E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.36|P-value:9.21E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.43|P-value:3.52E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.84|P-value:8.26E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.90|P-value:6.37E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.37|P-value:4.75E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.29|P-value:6.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.23|P-value:7.69E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.21|P-value:8.05E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.00|P-value:4.32E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.24|P-value:7.39E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.25|P-value:1.37E-5 ID:SGTC_1830|Compound:st055982|FD-Score:5.14|P-value:2.18E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.13|P-value:2.24E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.55|P-value:2.46E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.29|P-value:6.32E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.76|P-value:1.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.34|P-value:5.23E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.48|P-value:3.17E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.69|P-value:2.08E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.18|P-value:9.12E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.33|P-value:5.08E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.67|P-value:1.46E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.33|P-value:1.05E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.87|P-value:7.34E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.47|P-value:3.33E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.03|P-value:3.49E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-4.57|P-value:3.20E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.24|P-value:7.42E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.31|P-value:5.40E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.83|P-value:7.81E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.17|P-value:9.32E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.28|P-value:6.51E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.53|P-value:2.64E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.80|P-value:9.39E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.38|P-value:4.62E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.64|P-value:1.79E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.18|P-value:9.05E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.70|P-value:1.93E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.83|P-value:1.04E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.60|P-value:3.16E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.21|P-value:1.77E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.02|P-value:3.64E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.12|P-value:1.28E-19 ID:SGTC_376|Compound:3970-0862|FD-Score:4.70|P-value:1.99E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:4.90|P-value:7.23E-7 ID:SGTC_397|Compound:arbidol|FD-Score:-3.51|P-value:2.60E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.35|P-value:5.01E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.29|P-value:6.15E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.33|P-value:5.33E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.43|P-value:3.84E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.36|P-value:9.21E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.43|P-value:3.52E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.84|P-value:8.26E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.90|P-value:6.37E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.37|P-value:4.75E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.29|P-value:6.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.23|P-value:7.69E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.21|P-value:8.05E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.00|P-value:4.32E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.24|P-value:7.39E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.25|P-value:1.37E-5 ID:SGTC_1830|Compound:st055982|FD-Score:5.14|P-value:2.18E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.13|P-value:2.24E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.55|P-value:2.46E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.29|P-value:6.32E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.76|P-value:1.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.34|P-value:5.23E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.48|P-value:3.17E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.69|P-value:2.08E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.18|P-value:9.12E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.33|P-value:5.08E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.67|P-value:1.46E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.33|P-value:1.05E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.87|P-value:7.34E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.47|P-value:3.33E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.03|P-value:3.49E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-4.57|P-value:3.20E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.24|P-value:7.42E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.31|P-value:5.40E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.83|P-value:7.81E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.17|P-value:9.32E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.28|P-value:6.51E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.53|P-value:2.64E-4

Top fitness defect scores for YAL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1830 st055982 5.14 50.3 µM 2.18E-7 3 1.35E-7
2 SGTC_379 3970-0972 4.90 5.9 µM 7.23E-7 tubulin folding & SWR complex 12 4.68E-7
3 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.83 4.6 µM 1.04E-6 heat shock/prefoldin 25 6.80E-7
4 SGTC_241 5hr heat shock (37°C) + cantharidin 4.70 155.4 µM 1.93E-6 cell wall signaling 50 1.29E-6
5 SGTC_376 3970-0862 4.70 59.1 µM 1.99E-6 11 1.33E-6
6 SGTC_2156 5649887 4.69 115.0 µM 2.08E-6 RPP1 & pyrimidine depletion 3 1.39E-6
7 SGTC_2322 7413319 4.61 38.2 µM 3.00E-6 ERAD & cell cycle 118 2.03E-6
8 SGTC_243 5hr heat shock (37°C) + splitomicin 4.60 1.0 µM 3.16E-6 heat shock/prefoldin 31 2.14E-6
9 SGTC_892 0929-0076 4.36 29.0 µM 9.21E-6 TRP & mitochondrial translation 29 6.47E-6
10 SGTC_2665 lovastatin 4.33 100.0 µM 1.05E-5 6 7.38E-6
11 SGTC_273 hydroxyurea 4.21 18.1 mM 1.77E-5 heme biosynthesis & mitochondrial translocase 31 1.27E-5
12 SGTC_1227 3909-8010 4.00 46.6 µM 4.32E-5 15 3.19E-5
13 SGTC_1028 k015-0029 3.90 4.8 µM 6.37E-5 27 4.77E-5
14 SGTC_2682 pyrogallin 3.87 40.0 µM 7.34E-5 copper-dependent oxidative stress 28 5.52E-5
15 SGTC_988 1497-1057 3.84 103.0 µM 8.26E-5 12 6.23E-5
16 SGTC_14 0354-0009 3.80 295.0 µM 9.39E-5 30 7.11E-5
17 SGTC_1936 st074407 3.79 74.3 µM 1.01E-4 DNA damage response 40 7.68E-5
18 SGTC_1537 2',6'-dihydroxyflavanone 3.68 78.0 µM 1.53E-4 23 1.18E-4
19 SGTC_238 5hr heat shock (37°C) + nsc-638432 3.64 8.9 µM 1.79E-4 heat shock/prefoldin 52 1.39E-4
20 SGTC_2395 5646831 3.57 180.2 µM 2.30E-4 37 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.94E-32 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.185 2.48E-27 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.178 3.99E-25 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.174 2.33E-24 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.168 1.12E-22 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.165 7.84E-22 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.160 1.44E-20 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.157 6.92E-20 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.154 3.59E-19 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.154 3.65E-19 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.152 9.85E-19 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.149 4.20E-18 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.133 8.44E-15 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.133 9.13E-15 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.132 1.89E-14 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data