YAL053W / FLC2

Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL053W / FLC2

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:4.22|P-value:5.12E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.38|P-value:9.33E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.79|P-value:2.48E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:11.00|P-value:1.47E-24 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.27|P-value:3.93E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.10|P-value:8.09E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.39|P-value:1.97E-9 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.84|P-value:1.87E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.12|P-value:7.52E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:5.21|P-value:8.07E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:16.60|P-value:1.75E-53 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.67|P-value:3.42E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.33|P-value:3.03E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.27|P-value:4.21E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.52|P-value:5.64E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.21|P-value:5.30E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.81|P-value:3.12E-13 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.47|P-value:1.97E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.04|P-value:9.13E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:7.88|P-value:1.95E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.21|P-value:8.13E-7 ID:SGTC_1712|Compound:st032288|FD-Score:5.88|P-value:3.11E-8 ID:SGTC_1727|Compound:st034309|FD-Score:4.14|P-value:6.88E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.01|P-value:1.14E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.37|P-value:8.88E-4 ID:SGTC_2007|Compound:4011539|FD-Score:10.50|P-value:1.26E-22 ID:SGTC_2009|Compound:4012297|FD-Score:4.97|P-value:2.39E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.66|P-value:3.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.47|P-value:6.50E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.71|P-value:2.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.58|P-value:4.95E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.22|P-value:4.65E-5 ID:SGTC_2362|Compound:9071156|FD-Score:6.27|P-value:3.93E-9 ID:SGTC_2363|Compound:9053361|FD-Score:3.62|P-value:4.36E-4 ID:SGTC_2399|Compound:5884133|FD-Score:22.00|P-value:9.46E-92 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.19|P-value:5.27E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.19|P-value:5.34E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:8.84E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.13|P-value:6.51E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.42|P-value:2.14E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.44|P-value:7.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.47|P-value:1.93E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.61|P-value:4.14E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.50|P-value:6.02E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.80|P-value:2.33E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.85|P-value:2.00E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.63|P-value:4.21E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.59|P-value:4.85E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.22|P-value:4.60E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:1.05E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.35|P-value:9.63E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.47|P-value:7.17E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-6.93|P-value:7.57E-11 ID:SGTC_3266|Compound:9136860|FD-Score:-4.78|P-value:4.92E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.46|P-value:7.39E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.22|P-value:5.12E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.38|P-value:9.33E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.79|P-value:2.48E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:11.00|P-value:1.47E-24 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.27|P-value:3.93E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.10|P-value:8.09E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.39|P-value:1.97E-9 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.84|P-value:1.87E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.12|P-value:7.52E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:5.21|P-value:8.07E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:16.60|P-value:1.75E-53 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.67|P-value:3.42E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.33|P-value:3.03E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.27|P-value:4.21E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.52|P-value:5.64E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.21|P-value:5.30E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.81|P-value:3.12E-13 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.47|P-value:1.97E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.04|P-value:9.13E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:7.88|P-value:1.95E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.21|P-value:8.13E-7 ID:SGTC_1712|Compound:st032288|FD-Score:5.88|P-value:3.11E-8 ID:SGTC_1727|Compound:st034309|FD-Score:4.14|P-value:6.88E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.01|P-value:1.14E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.37|P-value:8.88E-4 ID:SGTC_2007|Compound:4011539|FD-Score:10.50|P-value:1.26E-22 ID:SGTC_2009|Compound:4012297|FD-Score:4.97|P-value:2.39E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.66|P-value:3.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.47|P-value:6.50E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.71|P-value:2.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.58|P-value:4.95E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.22|P-value:4.65E-5 ID:SGTC_2362|Compound:9071156|FD-Score:6.27|P-value:3.93E-9 ID:SGTC_2363|Compound:9053361|FD-Score:3.62|P-value:4.36E-4 ID:SGTC_2399|Compound:5884133|FD-Score:22.00|P-value:9.46E-92 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.19|P-value:5.27E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.19|P-value:5.34E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:8.84E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.13|P-value:6.51E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.42|P-value:2.14E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.44|P-value:7.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.47|P-value:1.93E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.61|P-value:4.14E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.50|P-value:6.02E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.80|P-value:2.33E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.85|P-value:2.00E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.63|P-value:4.21E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.59|P-value:4.85E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.22|P-value:4.60E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:1.05E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.35|P-value:9.63E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.47|P-value:7.17E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-6.93|P-value:7.57E-11 ID:SGTC_3266|Compound:9136860|FD-Score:-4.78|P-value:4.92E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.46|P-value:7.39E-4

Top fitness defect scores for YAL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2399 5884133 22.00 200.0 µM 9.46E-92 cell wall signaling 2 2.01E-107
2 SGTC_663 1486-0733 16.60 13.9 µM 1.75E-53 cell wall signaling 5 1.68E-62
3 SGTC_138 0850-0259 11.00 40.9 µM 1.47E-24 cell wall 36 1.50E-28
4 SGTC_2007 4011539 10.50 71.8 µM 1.26E-22 cell wall signaling 10 2.78E-26
5 SGTC_1392 3455-1037 7.88 33.9 µM 1.95E-13 2 1.68E-15
6 SGTC_1249 0481-0015 7.81 10.2 µM 3.12E-13 3 2.91E-15
7 SGTC_528 3492-0019 6.39 172.0 µM 1.97E-9 calcium & mitochondrial duress 113 8.26E-11
8 SGTC_2362 9071156 6.27 126.0 µM 3.93E-9 2 1.86E-10
9 SGTC_1712 st032288 5.88 53.4 µM 3.11E-8 calcium & mitochondrial duress 79 2.10E-9
10 SGTC_658 3253-0951 5.21 102.0 µM 8.07E-7 calcium & mitochondrial duress 28 9.48E-8
11 SGTC_1597 7-benzyloxygramine 5.21 47.5 µM 8.13E-7 calcium & mitochondrial duress 62 9.56E-8
12 SGTC_2009 4012297 4.97 12.1 µM 2.39E-6 cell wall signaling 36 3.37E-7
13 SGTC_2896 9052656 4.62 71.4 µM 1.05E-5 endomembrane recycling 75 1.91E-6
14 SGTC_2688 kanamycin b 4.47 96.7 µM 1.93E-5 calcium & mitochondrial duress 299 3.89E-6
15 SGTC_1259 0671-0132 4.47 43.0 µM 1.97E-5 14 3.97E-6
16 SGTC_727 3032-0951 4.27 202.0 µM 4.21E-5 22 9.67E-6
17 SGTC_42 0133-0086 4.22 60.6 µM 5.12E-5 22 1.21E-5
18 SGTC_1247 0448-0043 4.21 5.8 µM 5.30E-5 ERG2 32 1.26E-5
19 SGTC_1727 st034309 4.14 9.9 µM 6.88E-5 33 1.71E-5
20 SGTC_568 1193-0097 4.12 7.5 µM 7.52E-5 ERAD & cell cycle 137 1.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.410 4.81E-136 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.372 7.63E-111 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.343 3.05E-93 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.333 1.57E-87 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.308 1.11E-74 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.302 1.25E-71 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.296 4.48E-69 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.282 1.55E-62 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.275 3.03E-59 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.263 2.34E-54 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.255 9.27E-51 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.249 8.85E-49 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.231 9.07E-42 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.198 6.71E-31 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.189 2.14E-28 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence