YAL054C / ACS1

Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL054C / ACS1

Click on Significant Values for Screen Details ID:SGTC_341|Compound:1486-1430|FD-Score:-2.93|P-value:5.01E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.09|P-value:3.01E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.56|P-value:3.32E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.97|P-value:4.39E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.68|P-value:1.86E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.23|P-value:1.70E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.14|P-value:2.48E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.35|P-value:8.73E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.25|P-value:1.35E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.29|P-value:1.30E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.68|P-value:2.22E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.14|P-value:2.49E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.70|P-value:1.98E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.66|P-value:2.05E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.02|P-value:4.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:7.45|P-value:5.75E-17 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.36|P-value:8.19E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.83|P-value:7.50E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.82|P-value:9.48E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.08|P-value:3.22E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.98|P-value:4.84E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.61|P-value:2.69E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.47|P-value:4.97E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:5.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.42|P-value:6.48E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.68|P-value:2.16E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.23|P-value:1.32E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.72|P-value:7.71E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.12|P-value:2.35E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.09|P-value:2.34E-6 ID:SGTC_2710|Compound:st078562|FD-Score:-5.75|P-value:6.65E-11 ID:SGTC_2712|Compound:st079126|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.15|P-value:2.01E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.51|P-value:2.64E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-5.36|P-value:1.04E-9 ID:SGTC_2906|Compound:7926292|FD-Score:3.30|P-value:1.27E-4 ID:SGTC_2909|Compound:7941780|FD-Score:5.71|P-value:1.05E-10 ID:SGTC_2916|Compound:7875993|FD-Score:5.19|P-value:4.10E-9 ID:SGTC_2968|Compound:9090663|FD-Score:5.41|P-value:9.30E-10 ID:SGTC_2971|Compound:9092186|FD-Score:-6.82|P-value:1.29E-14 ID:SGTC_3265|Compound:9137266|FD-Score:3.86|P-value:9.29E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:3.12E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.93|P-value:5.01E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.09|P-value:3.01E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.56|P-value:3.32E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.97|P-value:4.39E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.68|P-value:1.86E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.23|P-value:1.70E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.14|P-value:2.48E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.35|P-value:8.73E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.25|P-value:1.35E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.29|P-value:1.30E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.68|P-value:2.22E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.14|P-value:2.49E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.70|P-value:1.98E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.66|P-value:2.05E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.02|P-value:4.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:7.45|P-value:5.75E-17 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.36|P-value:8.19E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.83|P-value:7.50E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.82|P-value:9.48E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.08|P-value:3.22E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.98|P-value:4.84E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.61|P-value:2.69E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.47|P-value:4.97E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:5.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.42|P-value:6.48E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.68|P-value:2.16E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.23|P-value:1.32E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.72|P-value:7.71E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.12|P-value:2.35E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.09|P-value:2.34E-6 ID:SGTC_2710|Compound:st078562|FD-Score:-5.75|P-value:6.65E-11 ID:SGTC_2712|Compound:st079126|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.15|P-value:2.01E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.51|P-value:2.64E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-5.36|P-value:1.04E-9 ID:SGTC_2906|Compound:7926292|FD-Score:3.30|P-value:1.27E-4 ID:SGTC_2909|Compound:7941780|FD-Score:5.71|P-value:1.05E-10 ID:SGTC_2916|Compound:7875993|FD-Score:5.19|P-value:4.10E-9 ID:SGTC_2968|Compound:9090663|FD-Score:5.41|P-value:9.30E-10 ID:SGTC_2971|Compound:9092186|FD-Score:-6.82|P-value:1.29E-14 ID:SGTC_3265|Compound:9137266|FD-Score:3.86|P-value:9.29E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:3.12E-4

Top fitness defect scores for YAL054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 7.45 707.4 nM 5.75E-17 redox potentiating 15 4.68E-14
2 SGTC_2909 7941780 5.71 10.5 µM 1.05E-10 3 5.49E-9
3 SGTC_2968 9090663 5.41 33.4 µM 9.30E-10 9 3.22E-8
4 SGTC_2916 7875993 5.19 68.8 µM 4.10E-9 7 1.07E-7
5 SGTC_2514 salinomycin 4.72 42.7 µM 7.71E-8 24 1.16E-6
6 SGTC_2831 7999036 4.51 19.5 µM 2.64E-7 29 3.17E-6
7 SGTC_2367 9070478 4.23 135.4 µM 1.32E-6 cell wall 25 1.17E-5
8 SGTC_2736 butenafine 4.15 14.7 µM 2.01E-6 25 1.65E-5
9 SGTC_3265 9137266 3.86 49.5 µM 9.29E-6 8 5.76E-5
10 SGTC_1033 k072-0102 3.70 21.3 µM 1.98E-5 60S ribosome export 29 1.07E-4
11 SGTC_2359 9039622 3.68 200.0 µM 2.16E-5 endomembrane recycling 28 1.15E-4
12 SGTC_996 3970-0799 3.68 1.8 µM 2.22E-5 96 1.17E-4
13 SGTC_2906 7926292 3.30 26.4 µM 1.27E-4 46 4.89E-4
14 SGTC_916 4466-0038 3.29 42.0 nM 1.30E-4 cell wall 110 4.97E-4
15 SGTC_806 3966-4455 3.23 5.9 µM 1.70E-4 49 6.19E-4
16 SGTC_904 1141-0088 3.14 396.0 µM 2.48E-4 47 8.45E-4
17 SGTC_1000 4048-0884 3.14 8.7 µM 2.49E-4 copper-dependent oxidative stress 62 8.47E-4
18 SGTC_537 1334-0398 3.09 209.0 µM 3.01E-4 61 9.90E-4
19 SGTC_3306 9127676 3.08 59.8 µM 3.12E-4 61 0.00102
20 SGTC_1561 5-methoxyflavone 3.08 52.9 µM 3.22E-4 19 0.00105

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.258 3.87E-52 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.225 7.30E-40 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.211 3.26E-35 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.195 3.67E-30 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.179 1.06E-25 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.170 2.88E-23 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.166 3.31E-22 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.166 4.76E-22 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.151 1.63E-18 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.143 8.78E-17 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.133 9.82E-15 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.123 9.80E-13 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.122 1.19E-12 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.117 1.02E-11 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.27E-11 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress