YAL055W / PEX22

Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL055W / PEX22

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.34|P-value:8.32E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.73|P-value:2.19E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.34|P-value:8.30E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.55|P-value:4.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.21|P-value:3.57E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.49|P-value:4.95E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.26|P-value:2.68E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:4.34|P-value:2.13E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.50|P-value:4.81E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:8.24E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.27|P-value:2.84E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.31|P-value:8.45E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:3.85E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.28|P-value:2.69E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.41|P-value:6.46E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.49|P-value:4.63E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.11|P-value:7.04E-7 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.87|P-value:2.18E-6 ID:SGTC_1904|Compound:st060225|FD-Score:3.29|P-value:9.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.49|P-value:4.66E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.41|P-value:6.10E-4 ID:SGTC_2008|Compound:4012253|FD-Score:7.69|P-value:1.89E-13 ID:SGTC_2093|Compound:5331342|FD-Score:-3.98|P-value:8.15E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-3.29|P-value:9.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.63|P-value:2.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.36|P-value:7.60E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.41|P-value:6.49E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.58|P-value:3.76E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.53|P-value:4.41E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.34|P-value:7.79E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.05|P-value:6.33E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.87|P-value:1.23E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.51|P-value:4.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.41|P-value:1.67E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.34|P-value:8.32E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.73|P-value:2.19E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.34|P-value:8.30E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.55|P-value:4.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.21|P-value:3.57E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.49|P-value:4.95E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.26|P-value:2.68E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:4.34|P-value:2.13E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.50|P-value:4.81E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:8.24E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.27|P-value:2.84E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.31|P-value:8.45E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:3.85E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.28|P-value:2.69E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.41|P-value:6.46E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.49|P-value:4.63E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.11|P-value:7.04E-7 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.87|P-value:2.18E-6 ID:SGTC_1904|Compound:st060225|FD-Score:3.29|P-value:9.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.49|P-value:4.66E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.41|P-value:6.10E-4 ID:SGTC_2008|Compound:4012253|FD-Score:7.69|P-value:1.89E-13 ID:SGTC_2093|Compound:5331342|FD-Score:-3.98|P-value:8.15E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-3.29|P-value:9.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.63|P-value:2.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.36|P-value:7.60E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.41|P-value:6.49E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.58|P-value:3.76E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.53|P-value:4.41E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.34|P-value:7.79E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.05|P-value:6.33E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.87|P-value:1.23E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.51|P-value:4.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.41|P-value:1.67E-7

Top fitness defect scores for YAL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2008 4012253 7.69 172.0 µM 1.89E-13 1 7.10E-15
2 SGTC_2939 9044578 5.41 71.4 µM 1.67E-7 18 3.17E-8
3 SGTC_1847 st056231 5.11 15.0 µM 7.04E-7 11 1.58E-7
4 SGTC_1879 gemcitabine 4.87 100.0 µM 2.18E-6 3 5.60E-7
5 SGTC_796 1234-0020 4.34 70.7 µM 2.13E-5 SWF1 & branched chain AA biosynthesis 19 7.13E-6
6 SGTC_1484 3473-2379 4.28 286.0 µM 2.69E-5 10 9.25E-6
7 SGTC_1165 k072-0275 4.27 30.3 µM 2.84E-5 33 9.83E-6
8 SGTC_690 glyoxal 4.21 20.3 µM 3.57E-5 72 1.27E-5
9 SGTC_6 0844-0013 3.94 19.8 µM 1.04E-4 90 4.16E-5
10 SGTC_331 k048-0133 3.73 24.5 µM 2.19E-4 RSC & ERG11 13 9.59E-5
11 SGTC_2477 5967686 3.58 25.2 µM 3.76E-4 38 1.75E-4
12 SGTC_496 calpeptin 3.55 138.0 µM 4.08E-4 24 1.91E-4
13 SGTC_2290 7904846 3.54 200.0 µM 4.29E-4 39 2.03E-4
14 SGTC_2485 5633444 3.53 17.8 µM 4.41E-4 redox potentiating 65 2.09E-4
15 SGTC_2777 climbazole 3.51 1.5 µM 4.73E-4 iron homeostasis 71 2.26E-4
16 SGTC_845 0330-0138 3.50 4.5 µM 4.81E-4 30 2.30E-4
17 SGTC_762 1165-0429 3.49 115.0 µM 4.95E-4 TSC3-RPN4 31 2.38E-4
18 SGTC_1650 st011916 3.41 45.8 µM 6.46E-4 24 3.20E-4
19 SGTC_2428 5615643 3.41 7.8 µM 6.49E-4 44 3.21E-4
20 SGTC_1681 tripelennamine 3.37 100.0 µM 7.46E-4 35 3.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.69E-10 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.099 1.02E-8 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.097 1.92E-8 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.087 4.03E-7 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.084 1.02E-6 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.082 2.23E-6 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.54E-6 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.080 3.63E-6 YOR124C UBP2 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
0.079 4.41E-6 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.077 8.09E-6 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.077 8.99E-6 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.076 9.28E-6 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.076 1.06E-5 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.074 1.73E-5 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.073 2.29E-5 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication