YAL056C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL056C-A / YAL056C-A

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:9.10|P-value:7.40E-19 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.73|P-value:1.26E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.26|P-value:8.82E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.73|P-value:1.27E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.96|P-value:7.21E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.06|P-value:3.39E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.91|P-value:6.23E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.71|P-value:1.84E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.44|P-value:3.62E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.40|P-value:8.14E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.39|P-value:5.79E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.52|P-value:3.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.62|P-value:1.97E-8 ID:SGTC_459|Compound:nigericin|FD-Score:8.20|P-value:1.20E-15 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.79|P-value:1.98E-6 ID:SGTC_469|Compound:w7|FD-Score:3.68|P-value:2.05E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:6.33|P-value:5.28E-10 ID:SGTC_543|Compound:3844-1095|FD-Score:3.98|P-value:6.61E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.99|P-value:6.35E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.30|P-value:1.75E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:11.10|P-value:2.55E-27 ID:SGTC_708|Compound:3448-5400|FD-Score:4.90|P-value:1.17E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.41|P-value:1.10E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.50|P-value:2.96E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.25|P-value:9.14E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.24|P-value:7.28E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.69|P-value:1.96E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.08|P-value:2.95E-15 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.24|P-value:7.29E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.20|P-value:8.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.81|P-value:1.80E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.12|P-value:2.71E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.07|P-value:4.53E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.52|P-value:3.60E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.82|P-value:1.20E-6 ID:SGTC_1563|Compound:conessine|FD-Score:3.44|P-value:4.78E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.75|P-value:1.16E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.49|P-value:7.79E-6 ID:SGTC_2007|Compound:4011539|FD-Score:10.30|P-value:1.18E-23 ID:SGTC_2009|Compound:4012297|FD-Score:9.37|P-value:7.02E-20 ID:SGTC_2035|Compound:5154463|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.32|P-value:7.20E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.24|P-value:9.39E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.04|P-value:5.28E-5 ID:SGTC_2272|Compound:7805186|FD-Score:4.45|P-value:9.19E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.36|P-value:4.27E-10 ID:SGTC_2304|Compound:7443016|FD-Score:6.70|P-value:5.10E-11 ID:SGTC_2308|Compound:7584454|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.05|P-value:3.63E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_2399|Compound:5884133|FD-Score:12.90|P-value:4.39E-36 ID:SGTC_2400|Compound:5203494|FD-Score:-4.36|P-value:9.80E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.56|P-value:3.14E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.63|P-value:2.44E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.46|P-value:6.32E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:5.79|P-value:1.22E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.51|P-value:3.80E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.89|P-value:6.86E-9 ID:SGTC_2787|Compound:5284540|FD-Score:-4.08|P-value:3.15E-5 ID:SGTC_2790|Compound:5423970|FD-Score:7.39|P-value:4.85E-13 ID:SGTC_2806|Compound:7952793|FD-Score:3.29|P-value:8.04E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.75|P-value:2.45E-6 ID:SGTC_3106|Compound:9121286|FD-Score:-3.45|P-value:3.53E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.47|P-value:3.26E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.59|P-value:2.35E-8 ID:SGTC_3162|Compound:9099653|FD-Score:-3.19|P-value:8.58E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.72|P-value:1.75E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:9.10|P-value:7.40E-19 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.73|P-value:1.26E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.26|P-value:8.82E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.73|P-value:1.27E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.96|P-value:7.21E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.06|P-value:3.39E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.91|P-value:6.23E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.71|P-value:1.84E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.44|P-value:3.62E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.40|P-value:8.14E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.39|P-value:5.79E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.52|P-value:3.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.62|P-value:1.97E-8 ID:SGTC_459|Compound:nigericin|FD-Score:8.20|P-value:1.20E-15 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.79|P-value:1.98E-6 ID:SGTC_469|Compound:w7|FD-Score:3.68|P-value:2.05E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:6.33|P-value:5.28E-10 ID:SGTC_543|Compound:3844-1095|FD-Score:3.98|P-value:6.61E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.99|P-value:6.35E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.30|P-value:1.75E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:11.10|P-value:2.55E-27 ID:SGTC_708|Compound:3448-5400|FD-Score:4.90|P-value:1.17E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.41|P-value:1.10E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.50|P-value:2.96E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.25|P-value:9.14E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.24|P-value:7.28E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.69|P-value:1.96E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.08|P-value:2.95E-15 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.24|P-value:7.29E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.20|P-value:8.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.81|P-value:1.80E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.12|P-value:2.71E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.07|P-value:4.53E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.52|P-value:3.60E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.82|P-value:1.20E-6 ID:SGTC_1563|Compound:conessine|FD-Score:3.44|P-value:4.78E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.75|P-value:1.16E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.49|P-value:7.79E-6 ID:SGTC_2007|Compound:4011539|FD-Score:10.30|P-value:1.18E-23 ID:SGTC_2009|Compound:4012297|FD-Score:9.37|P-value:7.02E-20 ID:SGTC_2035|Compound:5154463|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.32|P-value:7.20E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.24|P-value:9.39E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.04|P-value:5.28E-5 ID:SGTC_2272|Compound:7805186|FD-Score:4.45|P-value:9.19E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.36|P-value:4.27E-10 ID:SGTC_2304|Compound:7443016|FD-Score:6.70|P-value:5.10E-11 ID:SGTC_2308|Compound:7584454|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.05|P-value:3.63E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_2399|Compound:5884133|FD-Score:12.90|P-value:4.39E-36 ID:SGTC_2400|Compound:5203494|FD-Score:-4.36|P-value:9.80E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.56|P-value:3.14E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.63|P-value:2.44E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.46|P-value:6.32E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:5.79|P-value:1.22E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.51|P-value:3.80E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.89|P-value:6.86E-9 ID:SGTC_2787|Compound:5284540|FD-Score:-4.08|P-value:3.15E-5 ID:SGTC_2790|Compound:5423970|FD-Score:7.39|P-value:4.85E-13 ID:SGTC_2806|Compound:7952793|FD-Score:3.29|P-value:8.04E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.75|P-value:2.45E-6 ID:SGTC_3106|Compound:9121286|FD-Score:-3.45|P-value:3.53E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.47|P-value:3.26E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.59|P-value:2.35E-8 ID:SGTC_3162|Compound:9099653|FD-Score:-3.19|P-value:8.58E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.72|P-value:1.75E-4

Top fitness defect scores for YAL056C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2399 5884133 12.90 200.0 µM 4.39E-36 cell wall signaling 8 2.10E-38
2 SGTC_663 1486-0733 11.10 13.9 µM 2.55E-27 cell wall signaling 11 4.49E-29
3 SGTC_2007 4011539 10.30 71.8 µM 1.18E-23 cell wall signaling 11 3.58E-25
4 SGTC_2009 4012297 9.37 12.1 µM 7.02E-20 cell wall signaling 10 3.76E-21
5 SGTC_16 erodoxin 9.10 22.8 µM 7.40E-19 unfolded protein response 13 4.62E-20
6 SGTC_459 nigericin 8.20 15.3 µM 1.20E-15 10 1.22E-16
7 SGTC_800 3448-7362 8.08 155.0 µM 2.95E-15 translation 15 3.17E-16
8 SGTC_2790 5423970 7.39 71.4 µM 4.85E-13 endomembrane recycling 15 7.29E-14
9 SGTC_2304 7443016 6.70 91.4 µM 5.10E-11 7 1.04E-11
10 SGTC_2289 7946404 6.36 165.1 µM 4.27E-10 32 1.00E-10
11 SGTC_531 3788-1495 6.33 174.0 µM 5.28E-10 unfolded protein response 7 1.26E-10
12 SGTC_2782 7736369 5.89 71.4 µM 6.86E-9 7 1.94E-9
13 SGTC_2662 daunorubicin 5.79 22.4 µM 1.22E-8 anthracycline transcription coupled DNA repair 6 3.59E-9
14 SGTC_708 3448-5400 4.90 146.0 µM 1.17E-6 19 4.68E-7
15 SGTC_1018 4259-0013 4.81 28.1 µM 1.80E-6 5 7.39E-7
16 SGTC_464 bw-b 70c 4.79 158.0 µM 1.98E-6 8 8.18E-7
17 SGTC_2997 9067075 4.75 71.4 µM 2.45E-6 unfolded protein response 34 1.03E-6
18 SGTC_1874 staurosporine 4.49 7.6 µM 7.79E-6 cell wall signaling 18 3.53E-6
19 SGTC_2272 7805186 4.45 180.0 µM 9.19E-6 cell wall signaling 16 4.22E-6
20 SGTC_742 0kpi-0133 4.41 140.0 µM 1.10E-5 ERG2 15 5.11E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.431 2.03E-151 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.411 8.41E-137 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.401 6.60E-130 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.371 6.94E-110 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.355 2.57E-100 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.318 8.45E-80 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.308 1.11E-74 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.259 1.28E-52 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.251 3.85E-49 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.250 3.79E-49 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.250 6.41E-49 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.242 8.72E-46 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.238 2.50E-44 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.234 5.29E-43 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.229 5.81E-41 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p