YAL064C-A_p / TDA8

Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL064C-A / TDA8

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.12|P-value:1.06E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.40|P-value:2.94E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.19|P-value:6.51E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.41|P-value:2.60E-6 ID:SGTC_276|Compound:colchicine|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.44|P-value:1.87E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:6.53|P-value:9.33E-12 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.00|P-value:9.49E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.92|P-value:2.58E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.14|P-value:5.64E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.75|P-value:5.18E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.28|P-value:4.98E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.25|P-value:3.81E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.31|P-value:3.01E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.23|P-value:4.10E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.16|P-value:5.33E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.21|P-value:6.79E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.85|P-value:8.53E-10 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.99|P-value:9.68E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.16|P-value:8.67E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.28|P-value:3.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.15|P-value:5.51E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.66|P-value:7.78E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.63|P-value:8.64E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.14|P-value:7.68E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.22|P-value:9.79E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.29|P-value:3.26E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.13|P-value:5.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.51|P-value:1.62E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.38|P-value:3.04E-6 ID:SGTC_2171|Compound:5739187|FD-Score:7.52|P-value:5.36E-15 ID:SGTC_2189|Compound:6047310|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.95|P-value:2.25E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.93|P-value:2.44E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.63|P-value:8.76E-5 ID:SGTC_2480|Compound:5767542|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.22|P-value:6.42E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.17|P-value:1.08E-10 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.34|P-value:2.75E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.30|P-value:4.42E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.29|P-value:3.27E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.33|P-value:3.99E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.85|P-value:3.40E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.99|P-value:2.76E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.13|P-value:6.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.30|P-value:3.13E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.35|P-value:2.58E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.12|P-value:6.18E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.58|P-value:1.12E-6 ID:SGTC_3165|Compound:9101544|FD-Score:-3.62|P-value:1.25E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.09|P-value:6.75E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.52|P-value:9.65E-12 ID:SGTC_3291|Compound:9121177|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_3326|Compound:9140064|FD-Score:4.70|P-value:6.36E-7 ID:SGTC_49|Compound:0717-0965|FD-Score:4.12|P-value:1.06E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.40|P-value:2.94E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.19|P-value:6.51E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.41|P-value:2.60E-6 ID:SGTC_276|Compound:colchicine|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.44|P-value:1.87E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:6.53|P-value:9.33E-12 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.00|P-value:9.49E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.92|P-value:2.58E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.14|P-value:5.64E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.75|P-value:5.18E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.28|P-value:4.98E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.25|P-value:3.81E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.31|P-value:3.01E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.23|P-value:4.10E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.16|P-value:5.33E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.21|P-value:6.79E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.85|P-value:8.53E-10 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.99|P-value:9.68E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.16|P-value:8.67E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.28|P-value:3.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.15|P-value:5.51E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.66|P-value:7.78E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.63|P-value:8.64E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.14|P-value:7.68E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.22|P-value:9.79E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.29|P-value:3.26E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.13|P-value:5.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.51|P-value:1.62E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.38|P-value:3.04E-6 ID:SGTC_2171|Compound:5739187|FD-Score:7.52|P-value:5.36E-15 ID:SGTC_2189|Compound:6047310|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.95|P-value:2.25E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.93|P-value:2.44E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.63|P-value:8.76E-5 ID:SGTC_2480|Compound:5767542|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.22|P-value:6.42E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.17|P-value:1.08E-10 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.34|P-value:2.75E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.30|P-value:4.42E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.29|P-value:3.27E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.33|P-value:3.99E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.85|P-value:3.40E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.99|P-value:2.76E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.13|P-value:6.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.30|P-value:3.13E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.35|P-value:2.58E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.12|P-value:6.18E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.58|P-value:1.12E-6 ID:SGTC_3165|Compound:9101544|FD-Score:-3.62|P-value:1.25E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.09|P-value:6.75E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.52|P-value:9.65E-12 ID:SGTC_3291|Compound:9121177|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_3326|Compound:9140064|FD-Score:4.70|P-value:6.36E-7

Top fitness defect scores for YAL064C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2171 5739187 7.52 198.1 µM 5.36E-15 copper-dependent oxidative stress 6 2.79E-14
2 SGTC_418 lividomycin a 6.53 100.0 µM 9.33E-12 1 3.38E-11
3 SGTC_3289 9119912 6.52 71.4 µM 9.65E-12 1 3.49E-11
4 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.17 92.6 µM 1.08E-10 5 3.49E-10
5 SGTC_1164 k060-0068 5.85 93.7 µM 8.53E-10 4 2.48E-9
6 SGTC_3326 9140064 4.70 16.4 µM 6.36E-7 12 1.33E-6
7 SGTC_3136 9095672 4.58 49.5 µM 1.12E-6 11 2.29E-6
8 SGTC_2097 5376186 4.51 200.0 µM 1.62E-6 11 3.24E-6
9 SGTC_264 promethazine 4.41 12.5 mM 2.60E-6 DNA intercalators 39 5.07E-6
10 SGTC_2128 5255449 4.38 168.5 µM 3.04E-6 24 5.89E-6
11 SGTC_2730 imipramine 4.33 71.3 µM 3.99E-6 13 7.62E-6
12 SGTC_2552 juarezic acid 4.30 87.0 µM 4.42E-6 TSC3-RPN4 27 8.40E-6
13 SGTC_808 0711-0032 4.28 135.0 µM 4.98E-6 8 9.40E-6
14 SGTC_2507 purpurin 4.22 79.7 µM 6.42E-6 copper-dependent oxidative stress 29 1.20E-5
15 SGTC_1158 4092-0494 4.21 91.8 µM 6.79E-6 11 1.26E-5
16 SGTC_1494 4358-1428 4.16 177.0 µM 8.67E-6 17 1.59E-5
17 SGTC_49 0717-0965 4.12 32.1 µM 1.06E-5 60S ribosome export 19 1.94E-5
18 SGTC_3291 9121177 4.09 71.4 µM 1.18E-5 9 2.14E-5
19 SGTC_2292 7671323 3.95 168.1 µM 2.25E-5 RNA processing & uracil transport 30 3.93E-5
20 SGTC_2397 5161689 3.93 200.0 µM 2.44E-5 37 4.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.25E-10 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.100 6.05E-9 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.098 1.28E-8 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.091 1.20E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.087 4.12E-7 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.085 7.15E-7 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.084 1.10E-6 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.083 1.31E-6 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.083 1.40E-6 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.082 2.10E-6 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.080 3.43E-6 YMR179W SPT21 hom Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.079 4.97E-6 YDR113C PDS1 het Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.079 5.33E-6 YNL049C SFB2 hom Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p
0.078 5.83E-6 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.076 9.27E-6 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p