YAL065C_p

Putative protein of unknown function; has homology to FLO1; possible pseudogene

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL065C / YAL065C

Click on Significant Values for Screen Details ID:SGTC_173|Compound:1273-0061|FD-Score:5.28|P-value:5.55E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:5.00|P-value:2.50E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:3.79|P-value:6.68E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.68|P-value:1.87E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.27|P-value:6.35E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.63|P-value:1.56E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.26|P-value:6.59E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.23|P-value:7.47E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.17|P-value:9.03E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.39|P-value:4.27E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-3.55|P-value:2.34E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.15|P-value:9.74E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.57|P-value:2.17E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.24|P-value:7.03E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.14|P-value:2.14E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.06|P-value:9.92E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:4.60E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.01|P-value:2.37E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:6.36E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.21|P-value:7.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.74|P-value:8.28E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.82|P-value:8.16E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.24|P-value:7.12E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_2038|Compound:4100038|FD-Score:6.15|P-value:3.38E-10 ID:SGTC_2047|Compound:4141938|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.31|P-value:5.66E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_2214|Compound:7179297|FD-Score:-3.35|P-value:4.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.91|P-value:1.50E-9 ID:SGTC_2366|Compound:9070441|FD-Score:-3.45|P-value:3.39E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.40|P-value:4.65E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.47|P-value:3.19E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.62|P-value:8.37E-9 ID:SGTC_2832|Compound:7992762|FD-Score:3.95|P-value:3.37E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-4.39|P-value:7.12E-6 ID:SGTC_2869|Compound:9037858|FD-Score:4.01|P-value:2.71E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.89|P-value:4.39E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.32|P-value:5.29E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.67|P-value:1.47E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.26|P-value:4.97E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.82|P-value:8.26E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_3280|Compound:9140961|FD-Score:6.10|P-value:4.64E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:5.28|P-value:5.55E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:5.00|P-value:2.50E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:3.79|P-value:6.68E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.68|P-value:1.87E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.27|P-value:6.35E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.63|P-value:1.56E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.26|P-value:6.59E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.23|P-value:7.47E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.17|P-value:9.03E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.39|P-value:4.27E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-3.55|P-value:2.34E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.15|P-value:9.74E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.57|P-value:2.17E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.24|P-value:7.03E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.14|P-value:2.14E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.06|P-value:9.92E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:4.60E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.01|P-value:2.37E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:6.36E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.21|P-value:7.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.74|P-value:8.28E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.82|P-value:8.16E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.24|P-value:7.12E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_2038|Compound:4100038|FD-Score:6.15|P-value:3.38E-10 ID:SGTC_2047|Compound:4141938|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.31|P-value:5.66E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_2214|Compound:7179297|FD-Score:-3.35|P-value:4.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.91|P-value:1.50E-9 ID:SGTC_2366|Compound:9070441|FD-Score:-3.45|P-value:3.39E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.40|P-value:4.65E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.47|P-value:3.19E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.62|P-value:8.37E-9 ID:SGTC_2832|Compound:7992762|FD-Score:3.95|P-value:3.37E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-4.39|P-value:7.12E-6 ID:SGTC_2869|Compound:9037858|FD-Score:4.01|P-value:2.71E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.89|P-value:4.39E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.32|P-value:5.29E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.67|P-value:1.47E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.26|P-value:4.97E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.82|P-value:8.26E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_3280|Compound:9140961|FD-Score:6.10|P-value:4.64E-10

Top fitness defect scores for YAL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2038 4100038 6.15 31.0 µM 3.38E-10 plasma membrane duress 21 3.95E-10
2 SGTC_3280 9140961 6.10 49.5 µM 4.64E-10 60S ribosome export 3 5.43E-10
3 SGTC_2336 9001819 5.91 198.7 µM 1.50E-9 heme biosynthesis & mitochondrial translocase 9 1.75E-9
4 SGTC_2830 7992007 5.62 71.4 µM 8.37E-9 3 9.75E-9
5 SGTC_173 1273-0061 5.28 2.7 µM 5.55E-8 mitochondrial stress 136 6.43E-8
6 SGTC_1738 st035555 5.01 74.0 µM 2.37E-7 TSC3-RPN4 14 2.74E-7
7 SGTC_309 k408-0051 5.00 1.5 µM 2.50E-7 27 2.89E-7
8 SGTC_2887 9044784 4.89 58.4 µM 4.39E-7 fatty acid desaturase (OLE1) 12 5.07E-7
9 SGTC_512 prima-1 4.63 270.0 µM 1.56E-6 DNA intercalators 13 1.80E-6
10 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.40 70.0 µM 4.65E-6 redox potentiating 61 5.33E-6
11 SGTC_2869 9037858 4.01 32.5 µM 2.71E-5 11 3.08E-5
12 SGTC_2832 7992762 3.95 52.0 µM 3.37E-5 31 3.84E-5
13 SGTC_341 1486-1430 3.79 230.0 µM 6.68E-5 28 7.58E-5
14 SGTC_1980 st071811 3.74 45.7 µM 8.28E-5 RPP1 & pyrimidine depletion 23 9.38E-5
15 SGTC_829 1635-0120 3.67 117.0 µM 1.06E-4 DNA damage response 51 1.20E-4
16 SGTC_2028 5153890 3.60 36.4 µM 1.41E-4 cell wall signaling 41 1.59E-4
17 SGTC_2047 4141938 3.55 200.0 µM 1.68E-4 11 1.90E-4
18 SGTC_3263 9137018 3.54 49.5 µM 1.74E-4 28 1.97E-4
19 SGTC_409 arachidonic acid 3.47 100.0 µM 2.30E-4 27 2.59E-4
20 SGTC_2136 5328288 3.44 199.3 µM 2.61E-4 32 2.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.84E-16 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.138 9.28E-16 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.108 3.61E-10 YKL175W ZRT3 hom Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
0.101 4.43E-9 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.53E-8 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.093 7.82E-8 YAL008W FUN14 hom Mitochondrial protein of unknown function
0.089 2.79E-7 YOR178C GAC1 hom Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
0.087 4.00E-7 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.087 4.89E-7 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.084 1.01E-6 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.082 2.03E-6 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.082 2.13E-6 YIL001W_p YIL001W_p hom Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm
0.080 3.44E-6 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.077 8.02E-6 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.077 8.10E-6 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis