YAL067C / SEO1

Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL067C / SEO1

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.23|P-value:3.36E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.06|P-value:6.11E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.99|P-value:8.02E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.28|P-value:3.12E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.68|P-value:5.13E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-2.98|P-value:8.57E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.58|P-value:7.71E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.00|P-value:7.54E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:4.92E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.00|P-value:1.21E-5 ID:SGTC_1629|Compound:st005085|FD-Score:2.95|P-value:9.02E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.08|P-value:8.17E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-3.46|P-value:1.33E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.09|P-value:5.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.97|P-value:8.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.00|P-value:7.81E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.51|P-value:1.04E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.39|P-value:1.84E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.97|P-value:1.35E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.10|P-value:5.42E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.46|P-value:1.34E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.05|P-value:6.36E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.50|P-value:1.10E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.42|P-value:1.51E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.63|P-value:6.56E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.19|P-value:3.87E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.89|P-value:2.04E-5 ID:SGTC_3071|Compound:9117417|FD-Score:4.06|P-value:9.06E-6 ID:SGTC_3075|Compound:9116269|FD-Score:5.14|P-value:2.90E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-4.32|P-value:2.65E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-4.23|P-value:4.04E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.23|P-value:3.36E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.06|P-value:6.11E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:2.99|P-value:8.02E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.28|P-value:3.12E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.68|P-value:5.13E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-2.98|P-value:8.57E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.43|P-value:1.44E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.58|P-value:7.71E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.00|P-value:7.54E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:4.92E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.00|P-value:1.21E-5 ID:SGTC_1629|Compound:st005085|FD-Score:2.95|P-value:9.02E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.08|P-value:8.17E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-3.46|P-value:1.33E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.09|P-value:5.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.97|P-value:8.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.00|P-value:7.81E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.51|P-value:1.04E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.39|P-value:1.84E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.97|P-value:1.35E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.10|P-value:5.42E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.46|P-value:1.34E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.05|P-value:6.36E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.50|P-value:1.10E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.42|P-value:1.51E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.63|P-value:6.56E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.19|P-value:3.87E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.89|P-value:2.04E-5 ID:SGTC_3071|Compound:9117417|FD-Score:4.06|P-value:9.06E-6 ID:SGTC_3075|Compound:9116269|FD-Score:5.14|P-value:2.90E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-4.32|P-value:2.65E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-4.23|P-value:4.04E-6

Top fitness defect scores for YAL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_3075 9116269 5.14 49.5 µM 2.90E-8 8 1.39E-7
2 SGTC_505 gw-5074 4.28 63.9 µM 3.12E-6 48 9.44E-6
3 SGTC_1737 st035557 4.08 69.7 µM 8.17E-6 14 2.25E-5
4 SGTC_3071 9117417 4.06 49.5 µM 9.06E-6 fatty acid desaturase (OLE1) 16 2.47E-5
5 SGTC_1601 4'-hydroxyflavanone 4.00 55.5 µM 1.21E-5 RPP1 & pyrimidine depletion 29 3.19E-5
6 SGTC_2636 apigenin dimethyl ether 3.97 100.0 µM 1.35E-5 49 3.53E-5
7 SGTC_1580 hydrocortisone 21-hemisuccinate 3.69 43.2 µM 4.92E-5 22 1.13E-4
8 SGTC_610 4215-0184 3.68 155.0 µM 5.13E-5 exosome 19 1.18E-4
9 SGTC_1190 1486-1332 3.58 13.0 µM 7.71E-5 24 1.70E-4
10 SGTC_2600 tangeritin 3.51 88.0 µM 1.04E-4 53 2.23E-4
11 SGTC_2786 7743617 3.50 45.5 µM 1.10E-4 45 2.34E-4
12 SGTC_2640 pentamidine 3.46 10.4 µM 1.30E-4 mitochondrial processes 49 2.72E-4
13 SGTC_974 1326-0144 3.43 138.0 µM 1.44E-4 ERG2 66 3.00E-4
14 SGTC_2880 9042983 3.42 58.4 µM 1.51E-4 fatty acid desaturase (OLE1) 45 3.13E-4
15 SGTC_512 prima-1 3.15 270.0 µM 4.32E-4 DNA intercalators 49 8.07E-4
16 SGTC_1741 st038134 3.09 10.2 µM 5.50E-4 75 0.00100
17 SGTC_151 3013-0144 3.06 2.3 µM 6.11E-4 iron homeostasis 69 0.00110
18 SGTC_2779 methotrexate 3.05 400.0 µM 6.36E-4 64 0.00115
19 SGTC_2382 9035899 3.05 200.0 µM 6.40E-4 60S ribosome export 40 0.00115
20 SGTC_1554 st069299 3.00 38.7 µM 7.54E-4 60 0.00134

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.192 4.51E-29 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.117 8.84E-12 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.099 9.59E-9 YER132C PMD1 hom Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
0.085 8.21E-7 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.083 1.34E-6 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.083 1.44E-6 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.083 1.47E-6 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.083 1.52E-6 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.082 2.03E-6 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.082 2.11E-6 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.080 3.91E-6 YGR154C GTO1 hom Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.077 8.71E-6 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.076 1.16E-5 YNL228W_d YNL228W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
0.074 1.65E-5 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.074 1.80E-5 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases