YAL067W-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL067W-A / YAL067W-A

Click on Significant Values for Screen Details ID:SGTC_180|Compound:1486-1293|FD-Score:-3.88|P-value:6.28E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:4.56|P-value:1.88E-6 ID:SGTC_199|Compound:4063-0024|FD-Score:4.92|P-value:3.08E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:6.97|P-value:1.01E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:4.62|P-value:1.41E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.82|P-value:5.24E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:6.53E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.30|P-value:1.05E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:-5.19|P-value:1.37E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:6.79|P-value:3.50E-12 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.32|P-value:5.42E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.16|P-value:6.48E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.36|P-value:3.16E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.88|P-value:3.99E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.33|P-value:5.18E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.90|P-value:3.52E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:3.40|P-value:2.67E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.79|P-value:1.06E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.80|P-value:8.66E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.68|P-value:8.99E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:4.11|P-value:1.48E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.57|P-value:2.18E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.29|P-value:4.23E-8 ID:SGTC_1068|Compound:loratadine|FD-Score:3.89|P-value:3.93E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.34|P-value:4.98E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.20|P-value:8.21E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.18|P-value:1.81E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.86|P-value:4.43E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.76|P-value:6.64E-5 ID:SGTC_1647|Compound:st011722|FD-Score:-3.24|P-value:7.00E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.12|P-value:1.47E-5 ID:SGTC_1694|Compound:st024011|FD-Score:5.17|P-value:8.45E-8 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.41|P-value:3.87E-6 ID:SGTC_1867|Compound:st057372|FD-Score:4.20|P-value:1.02E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.84|P-value:4.83E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.67|P-value:9.49E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.25|P-value:1.31E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.01|P-value:2.33E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.03|P-value:2.17E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.05|P-value:9.32E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.50|P-value:2.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.67|P-value:9.62E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_2787|Compound:5284540|FD-Score:6.13|P-value:2.90E-10 ID:SGTC_2866|Compound:9034245|FD-Score:3.15|P-value:6.54E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.28|P-value:7.13E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.56|P-value:1.46E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.24|P-value:5.60E-8 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.88|P-value:6.28E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:4.56|P-value:1.88E-6 ID:SGTC_199|Compound:4063-0024|FD-Score:4.92|P-value:3.08E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:6.97|P-value:1.01E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:4.62|P-value:1.41E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.82|P-value:5.24E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:6.53E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.30|P-value:1.05E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:-5.19|P-value:1.37E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:6.79|P-value:3.50E-12 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.32|P-value:5.42E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.16|P-value:6.48E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.36|P-value:3.16E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.88|P-value:3.99E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.33|P-value:5.18E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.90|P-value:3.52E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:3.40|P-value:2.67E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.79|P-value:1.06E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.80|P-value:8.66E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.68|P-value:8.99E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:4.11|P-value:1.48E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.57|P-value:2.18E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.29|P-value:4.23E-8 ID:SGTC_1068|Compound:loratadine|FD-Score:3.89|P-value:3.93E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.34|P-value:4.98E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.20|P-value:8.21E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.18|P-value:1.81E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.86|P-value:4.43E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.76|P-value:6.64E-5 ID:SGTC_1647|Compound:st011722|FD-Score:-3.24|P-value:7.00E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.12|P-value:1.47E-5 ID:SGTC_1694|Compound:st024011|FD-Score:5.17|P-value:8.45E-8 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.41|P-value:3.87E-6 ID:SGTC_1867|Compound:st057372|FD-Score:4.20|P-value:1.02E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.84|P-value:4.83E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.67|P-value:9.49E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.25|P-value:1.31E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.01|P-value:2.33E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.03|P-value:2.17E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.05|P-value:9.32E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.50|P-value:2.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.67|P-value:9.62E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_2787|Compound:5284540|FD-Score:6.13|P-value:2.90E-10 ID:SGTC_2866|Compound:9034245|FD-Score:3.15|P-value:6.54E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.28|P-value:7.13E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.56|P-value:1.46E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.20|P-value:5.60E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.24|P-value:5.60E-8

Top fitness defect scores for YAL067W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_213 1246-0773 6.97 967.0 nM 1.01E-12 2 1.64E-12
2 SGTC_537 1334-0398 6.79 209.0 µM 3.50E-12 3 5.60E-12
3 SGTC_2787 5284540 6.13 71.4 µM 2.90E-10 6 4.40E-10
4 SGTC_1054 3429-0080 5.29 167.0 µM 4.23E-8 13 6.05E-8
5 SGTC_3305 9127027 5.24 53.8 µM 5.60E-8 5 7.96E-8
6 SGTC_1694 st024011 5.17 44.9 µM 8.45E-8 ERG2 16 1.20E-7
7 SGTC_199 4063-0024 4.92 41.6 µM 3.08E-7 1 4.28E-7
8 SGTC_790 1575-0012 4.90 79.1 µM 3.52E-7 TSC3-RPN4 12 4.88E-7
9 SGTC_236 1509-0011 4.62 5.3 µM 1.41E-6 352 1.92E-6
10 SGTC_198 3454-2873 4.56 16.2 µM 1.88E-6 60S ribosome export 8 2.54E-6
11 SGTC_1748 st037455 4.41 53.6 µM 3.87E-6 17 5.19E-6
12 SGTC_2934 9036370 4.28 36.9 µM 7.13E-6 24 9.49E-6
13 SGTC_1867 st057372 4.20 64.0 µM 1.02E-5 6 1.35E-5
14 SGTC_2783 7738165 4.16 71.4 µM 1.19E-5 25 1.57E-5
15 SGTC_1687 st020778 4.12 55.4 µM 1.47E-5 169 1.93E-5
16 SGTC_938 3126-1755 4.11 342.0 µM 1.48E-5 10 1.94E-5
17 SGTC_2061 5245884 4.03 81.0 µM 2.17E-5 tubulin folding & SWR complex 22 2.84E-5
18 SGTC_2033 5192550 4.01 145.0 µM 2.33E-5 13 3.05E-5
19 SGTC_1068 loratadine 3.89 26.9 µM 3.93E-5 27 5.09E-5
20 SGTC_730 1436-0052 3.88 41.2 µM 3.99E-5 mitochondrial processes 14 5.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.77E-11 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.114 3.43E-11 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.109 2.26E-10 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.107 4.46E-10 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.106 6.61E-10 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.103 1.99E-9 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.102 2.94E-9 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.102 2.96E-9 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.102 3.09E-9 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.102 3.20E-9 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.101 5.06E-9 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.101 5.53E-9 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.099 8.23E-9 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.097 1.86E-8 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.095 3.24E-8 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes