YAR002C-A / ERP1

Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR002C-A / ERP1

Click on Significant Values for Screen Details ID:SGTC_216|Compound:k038-0035|FD-Score:3.12|P-value:5.04E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.92|P-value:4.37E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.13|P-value:4.99E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.52|P-value:1.12E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.82|P-value:3.10E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:5.10|P-value:5.62E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.06|P-value:6.90E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.65|P-value:6.51E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.26|P-value:4.20E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.86|P-value:5.73E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.41|P-value:2.05E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:2.96|P-value:8.91E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.33|P-value:2.34E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.68|P-value:5.67E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.38|P-value:2.44E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.00|P-value:7.86E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.04|P-value:1.20E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.58|P-value:8.52E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.32|P-value:4.72E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.14|P-value:4.79E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.10|P-value:5.54E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.32|P-value:3.25E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-5.12|P-value:1.33E-7 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.55|P-value:1.98E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_2958|Compound:9077254|FD-Score:6.25|P-value:4.39E-11 ID:SGTC_2965|Compound:9082772|FD-Score:4.74|P-value:3.79E-7 ID:SGTC_2993|Compound:9054257|FD-Score:2.97|P-value:8.77E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.97|P-value:2.76E-10 ID:SGTC_3135|Compound:9127742|FD-Score:3.78|P-value:3.82E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.39|P-value:1.87E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.21|P-value:7.01E-4 ID:SGTC_3197|Compound:9113331|FD-Score:6.94|P-value:3.26E-13 ID:SGTC_3198|Compound:9112019|FD-Score:7.78|P-value:4.14E-16 ID:SGTC_3199|Compound:9111318|FD-Score:7.26|P-value:2.78E-14 ID:SGTC_3207|Compound:9114163|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.34|P-value:2.93E-6 ID:SGTC_3238|Compound:9133470|FD-Score:-4.01|P-value:3.02E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.86|P-value:5.65E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.13|P-value:5.01E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.41|P-value:3.47E-4 ID:SGTC_3339|Compound:9145883|FD-Score:5.38|P-value:1.08E-8 ID:SGTC_3353|Compound:9151644|FD-Score:3.18|P-value:4.08E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.12|P-value:5.04E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.92|P-value:4.37E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.13|P-value:4.99E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.52|P-value:1.12E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.82|P-value:3.10E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:5.10|P-value:5.62E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.06|P-value:6.90E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.65|P-value:6.51E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.26|P-value:4.20E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.86|P-value:5.73E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.41|P-value:2.05E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:2.96|P-value:8.91E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.33|P-value:2.34E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.68|P-value:5.67E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.38|P-value:2.44E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.00|P-value:7.86E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.04|P-value:1.20E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.58|P-value:8.52E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.32|P-value:4.72E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.14|P-value:4.79E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.10|P-value:5.54E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.32|P-value:3.25E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-5.12|P-value:1.33E-7 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.55|P-value:1.98E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_2958|Compound:9077254|FD-Score:6.25|P-value:4.39E-11 ID:SGTC_2965|Compound:9082772|FD-Score:4.74|P-value:3.79E-7 ID:SGTC_2993|Compound:9054257|FD-Score:2.97|P-value:8.77E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.97|P-value:2.76E-10 ID:SGTC_3135|Compound:9127742|FD-Score:3.78|P-value:3.82E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.39|P-value:1.87E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.21|P-value:7.01E-4 ID:SGTC_3197|Compound:9113331|FD-Score:6.94|P-value:3.26E-13 ID:SGTC_3198|Compound:9112019|FD-Score:7.78|P-value:4.14E-16 ID:SGTC_3199|Compound:9111318|FD-Score:7.26|P-value:2.78E-14 ID:SGTC_3207|Compound:9114163|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.34|P-value:2.93E-6 ID:SGTC_3238|Compound:9133470|FD-Score:-4.01|P-value:3.02E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.86|P-value:5.65E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.13|P-value:5.01E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.41|P-value:3.47E-4 ID:SGTC_3339|Compound:9145883|FD-Score:5.38|P-value:1.08E-8 ID:SGTC_3353|Compound:9151644|FD-Score:3.18|P-value:4.08E-4

Top fitness defect scores for YAR002C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3198 9112019 7.78 49.5 µM 4.14E-16 mitochondrial processes 1 3.67E-15
2 SGTC_3199 9111318 7.26 49.5 µM 2.78E-14 3 1.95E-13
3 SGTC_3197 9113331 6.94 49.5 µM 3.26E-13 2 2.00E-12
4 SGTC_2958 9077254 6.25 16.7 µM 4.39E-11 4 2.05E-10
5 SGTC_3091 9116372 5.97 49.5 µM 2.76E-10 2 1.16E-9
6 SGTC_3339 9145883 5.38 14.9 µM 1.08E-8 3 3.67E-8
7 SGTC_775 4577-0580 5.10 57.3 µM 5.62E-8 2 1.74E-7
8 SGTC_1155 4088-0394 5.06 48.2 µM 6.90E-8 6 2.11E-7
9 SGTC_2965 9082772 4.74 38.6 µM 3.79E-7 mitochondrial response to ROS 24 1.04E-6
10 SGTC_1385 3091-4834 4.41 14.1 µM 2.05E-6 RPP1 & pyrimidine depletion 11 5.12E-6
11 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.38 61.8 µM 2.44E-6 ergosterol biosynthesis 3 6.03E-6
12 SGTC_3235 9132602 4.34 49.5 µM 2.93E-6 15 7.15E-6
13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.32 70.0 µM 3.25E-6 redox potentiating 63 7.87E-6
14 SGTC_1259 0671-0132 4.26 43.0 µM 4.20E-6 19 1.00E-5
15 SGTC_1983 st071813 4.04 46.9 µM 1.20E-5 RPP1 & pyrimidine depletion 17 2.69E-5
16 SGTC_721 1187-1332 3.82 279.0 µM 3.10E-5 cell wall signaling 19 6.55E-5
17 SGTC_3135 9127742 3.78 49.5 µM 3.82E-5 27 7.96E-5
18 SGTC_1600 coumarin 106 3.68 71.1 µM 5.67E-5 32 1.15E-4
19 SGTC_1243 0416-0003 3.65 5.7 µM 6.51E-5 PDR1 38 1.31E-4
20 SGTC_2340 7987427 3.58 183.4 µM 8.52E-5 54 1.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.99E-10 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.083 1.54E-6 YKR096W ESL2 hom Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain
0.078 6.26E-6 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.075 1.23E-5 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.075 1.43E-5 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.074 1.61E-5 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.074 1.96E-5 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.073 2.07E-5 YER161C SPT2 hom Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
0.073 2.15E-5 YER185W PUG1 hom Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins
0.070 4.88E-5 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.068 8.71E-5 YGR268C HUA1 hom Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.067 1.01E-4 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.067 1.02E-4 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.067 1.09E-4 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.066 1.47E-4 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p