YAR003W / SWD1

Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR003W / SWD1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:5.47|P-value:1.92E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.22|P-value:4.79E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.47|P-value:7.05E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.20|P-value:5.21E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-4.40|P-value:1.38E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.71|P-value:3.12E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.45|P-value:7.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.90|P-value:9.70E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.78|P-value:2.40E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.89|P-value:1.01E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.38|P-value:3.08E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.42|P-value:8.15E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.38|P-value:2.57E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.75|P-value:2.68E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.20|P-value:5.27E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:-4.16|P-value:3.65E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.66|P-value:3.75E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.25|P-value:9.11E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.65|P-value:8.46E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.71|P-value:3.11E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.43|P-value:7.99E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.45|P-value:7.49E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.71|P-value:3.10E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.28|P-value:3.76E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.47|P-value:8.85E-10 ID:SGTC_1746|Compound:st038117|FD-Score:6.91|P-value:6.36E-11 ID:SGTC_1747|Compound:st037496|FD-Score:3.43|P-value:7.98E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.39|P-value:9.06E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.34|P-value:2.94E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.86|P-value:1.85E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.67|P-value:2.23E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.62|P-value:3.67E-10 ID:SGTC_2366|Compound:9070441|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.46|P-value:5.48E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:3.69|P-value:3.32E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.71|P-value:1.94E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.48|P-value:6.84E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.47|P-value:6.99E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:4.03E-5 ID:SGTC_2807|Compound:7945238|FD-Score:5.08|P-value:1.24E-6 ID:SGTC_2813|Compound:7971799|FD-Score:6.74|P-value:1.85E-10 ID:SGTC_2832|Compound:7992762|FD-Score:4.87|P-value:3.25E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.55|P-value:5.27E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.67|P-value:3.53E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.92|P-value:2.55E-6 ID:SGTC_3091|Compound:9116372|FD-Score:4.69|P-value:7.04E-6 ID:SGTC_3099|Compound:9120367|FD-Score:3.55|P-value:5.38E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.53|P-value:5.77E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.47|P-value:1.92E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.22|P-value:4.79E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.47|P-value:7.05E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.20|P-value:5.21E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-4.40|P-value:1.38E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.71|P-value:3.12E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.45|P-value:7.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.90|P-value:9.70E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.78|P-value:2.40E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.89|P-value:1.01E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.38|P-value:3.08E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.42|P-value:8.15E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.38|P-value:2.57E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.75|P-value:2.68E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.20|P-value:5.27E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:-4.16|P-value:3.65E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.66|P-value:3.75E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.25|P-value:9.11E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.65|P-value:8.46E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.71|P-value:3.11E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.43|P-value:7.99E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.45|P-value:7.49E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.71|P-value:3.10E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.28|P-value:3.76E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.47|P-value:8.85E-10 ID:SGTC_1746|Compound:st038117|FD-Score:6.91|P-value:6.36E-11 ID:SGTC_1747|Compound:st037496|FD-Score:3.43|P-value:7.98E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.39|P-value:9.06E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.34|P-value:2.94E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.86|P-value:1.85E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.67|P-value:2.23E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.62|P-value:3.67E-10 ID:SGTC_2366|Compound:9070441|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.46|P-value:5.48E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:3.69|P-value:3.32E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.71|P-value:1.94E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.48|P-value:6.84E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.47|P-value:6.99E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:4.03E-5 ID:SGTC_2807|Compound:7945238|FD-Score:5.08|P-value:1.24E-6 ID:SGTC_2813|Compound:7971799|FD-Score:6.74|P-value:1.85E-10 ID:SGTC_2832|Compound:7992762|FD-Score:4.87|P-value:3.25E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.55|P-value:5.27E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.67|P-value:3.53E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.92|P-value:2.55E-6 ID:SGTC_3091|Compound:9116372|FD-Score:4.69|P-value:7.04E-6 ID:SGTC_3099|Compound:9120367|FD-Score:3.55|P-value:5.38E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.53|P-value:5.77E-4

Top fitness defect scores for YAR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.46 100.0 µM 5.48E-19 redox potentiating 77 1.47E-21
2 SGTC_1746 st038117 6.91 42.0 µM 6.36E-11 3 2.35E-12
3 SGTC_2813 7971799 6.74 71.4 µM 1.85E-10 2 7.97E-12
4 SGTC_2365 9042475 6.62 200.0 µM 3.67E-10 6 1.74E-11
5 SGTC_1745 st081495 6.47 74.0 µM 8.85E-10 RNA processing & uracil transport 21 4.75E-11
6 SGTC_64 000l-0018 5.47 272.1 µM 1.92E-7 ubiquinone biosynthesis & proteasome 95 2.22E-8
7 SGTC_563 tetrahydrosecaminediol 5.38 614.0 µM 3.08E-7 amide catabolism 6 3.81E-8
8 SGTC_2807 7945238 5.08 52.0 µM 1.24E-6 10 1.86E-7
9 SGTC_3037 9091026 4.92 49.5 µM 2.55E-6 NEO1-PIK1 78 4.26E-7
10 SGTC_2832 7992762 4.87 52.0 µM 3.25E-6 16 5.62E-7
11 SGTC_3091 9116372 4.69 49.5 µM 7.04E-6 7 1.36E-6
12 SGTC_1331 1472-0049 4.65 76.2 µM 8.46E-6 8 1.68E-6
13 SGTC_976 1348-1067 4.38 47.6 µM 2.57E-5 60S ribosome export 19 5.99E-6
14 SGTC_1836 st055642 4.34 81.0 µM 2.94E-5 13 6.99E-6
15 SGTC_1661 st013063 4.28 9.7 µM 3.76E-5 22 9.26E-6
16 SGTC_2795 7780010 4.26 54.5 µM 4.03E-5 20 1.00E-5
17 SGTC_137 0438-0332 4.22 85.4 µM 4.79E-5 ubiquinone biosynthesis & proteasome 110 1.22E-5
18 SGTC_166 k072-0058 4.20 166.4 µM 5.21E-5 DNA intercalators 26 1.34E-5
19 SGTC_1128 3448-9350 4.20 235.0 µM 5.27E-5 19 1.36E-5
20 SGTC_1849 st056239 3.86 19.2 µM 1.85E-4 RPP1 & pyrimidine depletion 28 5.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.24E-41 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.194 7.00E-30 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.186 1.32E-27 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.186 2.20E-27 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.185 2.41E-27 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.172 8.67E-24 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.171 2.11E-23 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.170 3.08E-23 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.166 4.68E-22 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.162 2.81E-21 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.162 3.89E-21 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.161 8.03E-21 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.156 9.62E-20 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.155 1.88E-19 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.153 4.18E-19 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p