YAR014C / BUD14

Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR014C / BUD14

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.81|P-value:4.43E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.84|P-value:3.99E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.96|P-value:2.37E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.05|P-value:1.06E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.30|P-value:3.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:4.90|P-value:2.40E-7 ID:SGTC_567|Compound:1080-0542|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.37|P-value:3.61E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:5.07|P-value:9.39E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.86|P-value:3.59E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.28|P-value:5.37E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:3.70|P-value:7.25E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.45|P-value:1.95E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-6.61|P-value:5.18E-12 ID:SGTC_951|Compound:1171-0579|FD-Score:8.02|P-value:8.36E-17 ID:SGTC_952|Compound:1185-0122|FD-Score:7.05|P-value:2.13E-13 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:3.18E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.30|P-value:4.87E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:4.16|P-value:9.38E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:5.41|P-value:1.37E-8 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.41|P-value:2.85E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.86|P-value:3.66E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.50|P-value:1.91E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.05|P-value:8.55E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.04|P-value:8.86E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.29|P-value:3.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.53|P-value:1.43E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.15|P-value:5.97E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1648|Compound:st011736|FD-Score:4.26|P-value:5.83E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.65|P-value:8.76E-7 ID:SGTC_1897|Compound:st060201|FD-Score:3.40|P-value:2.36E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-7.38|P-value:1.59E-14 ID:SGTC_1923|Compound:st058458|FD-Score:5.25|P-value:3.35E-8 ID:SGTC_1925|Compound:st057770|FD-Score:4.85|P-value:3.08E-7 ID:SGTC_1927|Compound:st060202|FD-Score:-3.73|P-value:6.19E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.65|P-value:8.54E-7 ID:SGTC_1935|Compound:st074532|FD-Score:4.80|P-value:3.99E-7 ID:SGTC_1937|Compound:st074714|FD-Score:8.08|P-value:4.83E-17 ID:SGTC_1943|Compound:st076331|FD-Score:3.15|P-value:6.02E-4 ID:SGTC_1967|Compound:st070177|FD-Score:5.18|P-value:4.96E-8 ID:SGTC_2125|Compound:5246583|FD-Score:4.06|P-value:1.52E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.97|P-value:2.28E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.25|P-value:6.15E-6 ID:SGTC_2312|Compound:7706453|FD-Score:3.10|P-value:7.15E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.35|P-value:1.88E-8 ID:SGTC_2444|Compound:5485484|FD-Score:3.83|P-value:4.11E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.35|P-value:2.84E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.78|P-value:5.14E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.62|P-value:9.86E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.42|P-value:2.07E-11 ID:SGTC_2833|Compound:9001315|FD-Score:3.12|P-value:6.63E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.94|P-value:2.54E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.19|P-value:5.17E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.16|P-value:5.50E-8 ID:SGTC_2878|Compound:9043973|FD-Score:4.25|P-value:6.30E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.24|P-value:4.41E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.19|P-value:4.72E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.22|P-value:4.66E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.48|P-value:1.71E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.06|P-value:8.38E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.81|P-value:4.43E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.84|P-value:3.99E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.96|P-value:2.37E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.05|P-value:1.06E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.30|P-value:3.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:1.63E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:4.90|P-value:2.40E-7 ID:SGTC_567|Compound:1080-0542|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.37|P-value:3.61E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:5.07|P-value:9.39E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.86|P-value:3.59E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.28|P-value:5.37E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:3.70|P-value:7.25E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.45|P-value:1.95E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-6.61|P-value:5.18E-12 ID:SGTC_951|Compound:1171-0579|FD-Score:8.02|P-value:8.36E-17 ID:SGTC_952|Compound:1185-0122|FD-Score:7.05|P-value:2.13E-13 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:3.18E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.30|P-value:4.87E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:4.16|P-value:9.38E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:5.41|P-value:1.37E-8 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.41|P-value:2.85E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.86|P-value:3.66E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.50|P-value:1.91E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.05|P-value:8.55E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.04|P-value:8.86E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.29|P-value:3.57E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.53|P-value:1.43E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.15|P-value:5.97E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1648|Compound:st011736|FD-Score:4.26|P-value:5.83E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.65|P-value:8.76E-7 ID:SGTC_1897|Compound:st060201|FD-Score:3.40|P-value:2.36E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-7.38|P-value:1.59E-14 ID:SGTC_1923|Compound:st058458|FD-Score:5.25|P-value:3.35E-8 ID:SGTC_1925|Compound:st057770|FD-Score:4.85|P-value:3.08E-7 ID:SGTC_1927|Compound:st060202|FD-Score:-3.73|P-value:6.19E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.65|P-value:8.54E-7 ID:SGTC_1935|Compound:st074532|FD-Score:4.80|P-value:3.99E-7 ID:SGTC_1937|Compound:st074714|FD-Score:8.08|P-value:4.83E-17 ID:SGTC_1943|Compound:st076331|FD-Score:3.15|P-value:6.02E-4 ID:SGTC_1967|Compound:st070177|FD-Score:5.18|P-value:4.96E-8 ID:SGTC_2125|Compound:5246583|FD-Score:4.06|P-value:1.52E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.97|P-value:2.28E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.25|P-value:6.15E-6 ID:SGTC_2312|Compound:7706453|FD-Score:3.10|P-value:7.15E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.35|P-value:1.88E-8 ID:SGTC_2444|Compound:5485484|FD-Score:3.83|P-value:4.11E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.35|P-value:2.84E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.78|P-value:5.14E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.62|P-value:9.86E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.42|P-value:2.07E-11 ID:SGTC_2833|Compound:9001315|FD-Score:3.12|P-value:6.63E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.94|P-value:2.54E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.19|P-value:5.17E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.16|P-value:5.50E-8 ID:SGTC_2878|Compound:9043973|FD-Score:4.25|P-value:6.30E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.24|P-value:4.41E-4 ID:SGTC_2985|Compound:9022375|FD-Score:5.19|P-value:4.72E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.22|P-value:4.66E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.48|P-value:1.71E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.06|P-value:8.38E-4

Top fitness defect scores for YAR014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1937 st074714 8.08 47.2 µM 4.83E-17 6 3.21E-16
2 SGTC_951 1171-0579 8.02 82.7 µM 8.36E-17 cell wall 16 5.40E-16
3 SGTC_952 1185-0122 7.05 232.0 µM 2.13E-13 5 9.05E-13
4 SGTC_2780 5215298 6.42 71.4 µM 2.07E-11 4 6.89E-11
5 SGTC_1143 3454-2408 5.41 5.1 µM 1.37E-8 60S ribosome export 1 3.22E-8
6 SGTC_2443 5493264 5.35 126.7 µM 1.88E-8 9 4.35E-8
7 SGTC_1923 st058458 5.25 19.1 µM 3.35E-8 11 7.54E-8
8 SGTC_2985 9022375 5.19 71.4 µM 4.72E-8 RPP1 & pyrimidine depletion 10 1.04E-7
9 SGTC_1967 st070177 5.18 51.4 µM 4.96E-8 4 1.09E-7
10 SGTC_2857 9024691 5.16 58.4 µM 5.50E-8 7 1.20E-7
11 SGTC_761 k216-0224 5.07 480.0 µM 9.39E-8 6 2.00E-7
12 SGTC_221 trifluoperazine 5.05 10.3 µM 1.06E-7 NEO1-PIK1 160 2.25E-7
13 SGTC_561 1550-0330 4.90 72.9 µM 2.40E-7 5 4.86E-7
14 SGTC_1925 st057770 4.85 10.1 µM 3.08E-7 TSC3-RPN4 10 6.17E-7
15 SGTC_1935 st074532 4.80 41.6 µM 3.99E-7 14 7.87E-7
16 SGTC_1749 st037932 4.65 54.2 µM 8.76E-7 20 1.66E-6
17 SGTC_1250 0485-0349 4.50 40.2 µM 1.91E-6 19 3.47E-6
18 SGTC_1150 3909-7983 4.41 10.9 µM 2.85E-6 14 5.08E-6
19 SGTC_585 0kpi-0023 4.37 191.0 µM 3.61E-6 13 6.35E-6
20 SGTC_986 1493-0483 4.30 84.0 µM 4.87E-6 9 8.44E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.29E-12 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.118 6.79E-12 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.115 2.85E-11 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.110 1.63E-10 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.099 1.05E-8 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.095 3.70E-8 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.095 3.89E-8 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.094 5.10E-8 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.094 5.82E-8 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.094 5.79E-8 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.091 1.17E-7 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.090 1.79E-7 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.083 1.30E-6 YNL059C ARP5 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.081 2.80E-6 YLR434C_d YLR434C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
0.080 3.43E-6 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria