YAR023C_p

Putative integral membrane protein, member of DUP240 gene family

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR023C / YAR023C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:4.27|P-value:7.67E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.28|P-value:4.54E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.81|P-value:5.82E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:6.59|P-value:1.18E-11 ID:SGTC_153|Compound:4077-0274|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.88|P-value:3.90E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_271|Compound:rotenone|FD-Score:-3.52|P-value:1.68E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.99|P-value:2.68E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:9.25E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.28|P-value:4.52E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.78|P-value:6.40E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.32|P-value:3.96E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.48|P-value:1.41E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.33|P-value:5.71E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.90|P-value:3.98E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.95|P-value:2.60E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.76|P-value:7.14E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:4.94E-6 ID:SGTC_1820|Compound:st053765|FD-Score:4.56|P-value:1.91E-6 ID:SGTC_1822|Compound:st052468|FD-Score:4.56|P-value:1.93E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-3.97|P-value:2.60E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.09|P-value:8.98E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.39|P-value:3.05E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.74|P-value:7.59E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.68|P-value:1.08E-6 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.14|P-value:6.88E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.21|P-value:5.82E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.23|P-value:5.45E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.15|P-value:6.72E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.27|P-value:7.67E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.28|P-value:4.54E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.81|P-value:5.82E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:6.59|P-value:1.18E-11 ID:SGTC_153|Compound:4077-0274|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.88|P-value:3.90E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_271|Compound:rotenone|FD-Score:-3.52|P-value:1.68E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.99|P-value:2.68E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:9.25E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.28|P-value:4.52E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.78|P-value:6.40E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.32|P-value:3.96E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.48|P-value:1.41E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.33|P-value:5.71E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.90|P-value:3.98E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.95|P-value:2.60E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.76|P-value:7.14E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:4.94E-6 ID:SGTC_1820|Compound:st053765|FD-Score:4.56|P-value:1.91E-6 ID:SGTC_1822|Compound:st052468|FD-Score:4.56|P-value:1.93E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-3.97|P-value:2.60E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.09|P-value:8.98E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.39|P-value:3.05E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.74|P-value:7.59E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.68|P-value:1.08E-6 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.14|P-value:6.88E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.21|P-value:5.82E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.23|P-value:5.45E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.15|P-value:6.72E-4

Top fitness defect scores for YAR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_143 4032-1194 6.59 15.7 µM 1.18E-11 14 2.20E-11
2 SGTC_1045 1348-1485 5.48 165.0 µM 1.41E-8 8 2.14E-8
3 SGTC_1243 0416-0003 4.95 5.7 µM 2.60E-7 PDR1 10 3.65E-7
4 SGTC_184 1494-0393 4.88 24.7 µM 3.90E-7 36 5.42E-7
5 SGTC_2634 4'-methoxyflavone 4.68 100.0 µM 1.08E-6 18 1.46E-6
6 SGTC_1820 st053765 4.56 18.6 µM 1.91E-6 RPP1 & pyrimidine depletion 7 2.54E-6
7 SGTC_1822 st052468 4.56 42.0 µM 1.93E-6 5 2.57E-6
8 SGTC_1580 hydrocortisone 21-hemisuccinate 4.36 43.2 µM 4.94E-6 15 6.40E-6
9 SGTC_1076 itraconazole 4.33 331.0 nM 5.71E-6 26 7.37E-6
10 SGTC_42 0133-0086 4.27 60.6 µM 7.67E-6 21 9.83E-6
11 SGTC_991 3996-0057 4.00 64.7 µM 2.59E-5 19 3.21E-5
12 SGTC_571 k831-0106 3.99 44.2 µM 2.68E-5 12 3.32E-5
13 SGTC_235 0330-0087 3.93 5.0 mM 3.47E-5 TSC3-RPN4 23 4.26E-5
14 SGTC_1106 tegaserod maleate 3.90 11.7 µM 3.98E-5 17 4.87E-5
15 SGTC_139 0099-0334 3.81 718.6 µM 5.82E-5 35 7.06E-5
16 SGTC_784 4579-0127 3.78 173.0 µM 6.40E-5 25 7.74E-5
17 SGTC_1564 D-Arginine 3.76 115.0 µM 7.14E-5 31 8.62E-5
18 SGTC_2131 toluylene red 3.74 5.3 µM 7.59E-5 60S ribosome export 29 9.15E-5
19 SGTC_583 1488-1091 3.64 88.9 µM 1.15E-4 27 1.37E-4
20 SGTC_939 1165-0479 3.51 45.3 µM 1.93E-4 51 2.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.26E-12 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.120 3.36E-12 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.100 6.45E-9 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.099 9.73E-9 YIL074C SER33 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication
0.098 1.53E-8 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.096 2.38E-8 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.092 9.92E-8 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.085 8.90E-7 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.084 1.03E-6 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.083 1.40E-6 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.083 1.51E-6 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.081 2.38E-6 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.081 2.76E-6 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.079 4.51E-6 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.076 1.02E-5 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR