YAR028W_p

Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR028W / YAR028W

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:-3.51|P-value:4.84E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.84|P-value:1.54E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.80|P-value:1.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.12|P-value:5.75E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.33|P-value:8.75E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.37|P-value:7.87E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.38|P-value:2.36E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:4.60|P-value:8.10E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.93|P-value:1.12E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.64|P-value:6.73E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:5.87|P-value:1.88E-8 ID:SGTC_784|Compound:4579-0127|FD-Score:4.52|P-value:1.14E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.53|P-value:1.11E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.41|P-value:6.92E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.92|P-value:1.92E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.08|P-value:6.59E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.30|P-value:9.86E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.61|P-value:2.83E-10 ID:SGTC_2119|Compound:5528445|FD-Score:-3.29|P-value:9.94E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.00|P-value:8.78E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.48|P-value:1.34E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-5.01|P-value:1.27E-6 ID:SGTC_2302|Compound:7771753|FD-Score:4.09|P-value:6.43E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.35|P-value:8.23E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.99|P-value:8.98E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.97|P-value:9.83E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.31|P-value:9.68E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.35|P-value:2.23E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-4.67|P-value:5.83E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.07|P-value:6.92E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.66|P-value:6.36E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.37|P-value:7.75E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.08|P-value:6.73E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.40|P-value:7.22E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.04|P-value:7.67E-5 ID:SGTC_3267|Compound:9137951|FD-Score:-4.21|P-value:3.84E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-4.02|P-value:7.90E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.51|P-value:4.84E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.84|P-value:1.54E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.80|P-value:1.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.12|P-value:5.75E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.33|P-value:8.75E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.37|P-value:7.87E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.38|P-value:2.36E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:4.60|P-value:8.10E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.93|P-value:1.12E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.64|P-value:6.73E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:5.87|P-value:1.88E-8 ID:SGTC_784|Compound:4579-0127|FD-Score:4.52|P-value:1.14E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.53|P-value:1.11E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.41|P-value:6.92E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.92|P-value:1.92E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.08|P-value:6.59E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.30|P-value:9.86E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.61|P-value:2.83E-10 ID:SGTC_2119|Compound:5528445|FD-Score:-3.29|P-value:9.94E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.00|P-value:8.78E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.48|P-value:1.34E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-5.01|P-value:1.27E-6 ID:SGTC_2302|Compound:7771753|FD-Score:4.09|P-value:6.43E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.35|P-value:8.23E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.99|P-value:8.98E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.97|P-value:9.83E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.31|P-value:9.68E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.35|P-value:2.23E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-4.67|P-value:5.83E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.07|P-value:6.92E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.66|P-value:6.36E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.37|P-value:7.75E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.08|P-value:6.73E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.40|P-value:7.22E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.04|P-value:7.67E-5 ID:SGTC_3267|Compound:9137951|FD-Score:-4.21|P-value:3.84E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-4.02|P-value:7.90E-5

Top fitness defect scores for YAR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2056 5235370 6.61 200.0 µM 2.83E-10 9 1.86E-11
2 SGTC_779 1360-0071 5.87 233.0 µM 1.88E-8 fatty acid desaturase (OLE1) 7 2.17E-9
3 SGTC_424 splitomicin 5.38 100.0 mM 2.36E-7 5 3.82E-8
4 SGTC_3047 9092122 4.66 49.5 µM 6.36E-6 9 1.59E-6
5 SGTC_502 l-744,832 4.60 89.3 µM 8.10E-6 calcium & mitochondrial duress 27 2.09E-6
6 SGTC_869 0564-0080 4.53 44.1 µM 1.11E-5 12 3.00E-6
7 SGTC_784 4579-0127 4.52 173.0 µM 1.14E-5 10 3.07E-6
8 SGTC_2167 5876490 4.48 200.0 µM 1.34E-5 17 3.70E-6
9 SGTC_212 3807-4682 4.12 38.8 µM 5.75E-5 tubulin folding & SWR complex 61 1.92E-5
10 SGTC_2302 7771753 4.09 200.0 µM 6.43E-5 40 2.18E-5
11 SGTC_1402 3909-7673 4.08 35.9 µM 6.59E-5 21 2.24E-5
12 SGTC_3124 9127567 4.08 49.5 µM 6.73E-5 DNA damage response 14 2.30E-5
13 SGTC_2995 9067767 4.07 71.4 µM 6.92E-5 19 2.37E-5
14 SGTC_3199 9111318 4.04 49.5 µM 7.67E-5 17 2.67E-5
15 SGTC_2136 5328288 4.00 199.3 µM 8.78E-5 19 3.10E-5
16 SGTC_2476 5806916 3.97 10.5 µM 9.83E-5 14 3.53E-5
17 SGTC_1550 gossypolone 3.87 36.6 µM 1.42E-4 15 5.34E-5
18 SGTC_117 lucigenin 3.80 22.1 µM 1.84E-4 redox potentiating 90 7.17E-5
19 SGTC_2479 5617353 3.77 43.9 µM 2.08E-4 43 8.21E-5
20 SGTC_828 2074-0507 3.44 139.0 µM 6.38E-4 RPP1 & pyrimidine depletion 36 2.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 2.80E-12 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.091 1.15E-7 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.091 1.46E-7 YLR275W SMD2 het Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
0.088 2.94E-7 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.088 3.58E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.080 3.48E-6 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.077 8.91E-6 YPL253C VIK1 hom Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
0.073 2.42E-5 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.072 2.74E-5 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.072 3.22E-5 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.071 3.43E-5 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.071 3.84E-5 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.070 4.44E-5 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.070 4.77E-5 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.070 5.46E-5 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro