YAR029W_p

Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR029W / YAR029W

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:3.01|P-value:8.51E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.87|P-value:1.98E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:4.13|P-value:8.70E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.14|P-value:8.27E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.29|P-value:3.13E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.05|P-value:7.43E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.98|P-value:9.52E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.08|P-value:6.74E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.49|P-value:1.42E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.02|P-value:8.21E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.41|P-value:9.14E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:5.28|P-value:1.94E-8 ID:SGTC_1606|Compound:st000094|FD-Score:6.39|P-value:1.49E-11 ID:SGTC_1668|Compound:st014914|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.68|P-value:6.28E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.72|P-value:5.49E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.77|P-value:4.30E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.12|P-value:5.87E-4 ID:SGTC_2460|Compound:5552655|FD-Score:11.50|P-value:4.40E-33 ID:SGTC_2481|Compound:5478948|FD-Score:3.89|P-value:2.52E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.83|P-value:3.42E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.08|P-value:6.77E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.04|P-value:1.30E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-2.99|P-value:9.34E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.02|P-value:8.31E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.14|P-value:8.02E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.69|P-value:6.25E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-4.32|P-value:3.47E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.29|P-value:3.05E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.02|P-value:8.37E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-4.00|P-value:1.61E-5 ID:SGTC_3353|Compound:9151644|FD-Score:3.23|P-value:3.86E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.01|P-value:8.51E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.87|P-value:1.98E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:4.13|P-value:8.70E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.14|P-value:8.27E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.29|P-value:3.13E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.05|P-value:7.43E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.98|P-value:9.52E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.08|P-value:6.74E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.49|P-value:1.42E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.02|P-value:8.21E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.41|P-value:9.14E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:5.28|P-value:1.94E-8 ID:SGTC_1606|Compound:st000094|FD-Score:6.39|P-value:1.49E-11 ID:SGTC_1668|Compound:st014914|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.68|P-value:6.28E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.72|P-value:5.49E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.77|P-value:4.30E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.12|P-value:5.87E-4 ID:SGTC_2460|Compound:5552655|FD-Score:11.50|P-value:4.40E-33 ID:SGTC_2481|Compound:5478948|FD-Score:3.89|P-value:2.52E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.83|P-value:3.42E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.08|P-value:6.77E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.04|P-value:1.30E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-2.99|P-value:9.34E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.02|P-value:8.31E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.14|P-value:8.02E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.69|P-value:6.25E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-4.32|P-value:3.47E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.29|P-value:3.05E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.02|P-value:8.37E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-4.00|P-value:1.61E-5 ID:SGTC_3353|Compound:9151644|FD-Score:3.23|P-value:3.86E-4

Top fitness defect scores for YAR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2460 5552655 11.50 174.2 µM 4.40E-33 amide catabolism 2 1.07E-30
2 SGTC_1606 st000094 6.39 49.2 µM 1.49E-11 60S ribosome export 1 8.47E-11
3 SGTC_1510 1123-0200 5.41 71.5 µM 9.14E-9 19 3.21E-8
4 SGTC_1529 apigenin 5.28 74.0 µM 1.94E-8 10 6.43E-8
5 SGTC_212 3807-4682 4.87 38.8 µM 1.98E-7 tubulin folding & SWR complex 40 5.52E-7
6 SGTC_3073 9114972 4.14 49.5 µM 8.02E-6 60S ribosome export 9 1.70E-5
7 SGTC_802 4112-3352 4.14 742.0 µM 8.27E-6 20 1.75E-5
8 SGTC_751 0833-0568 4.13 350.0 µM 8.70E-6 16 1.84E-5
9 SGTC_2919 7978188 4.04 46.4 µM 1.30E-5 16 2.66E-5
10 SGTC_345 1362-0200 3.92 395.0 µM 2.25E-5 16 4.43E-5
11 SGTC_2481 5478948 3.89 45.2 µM 2.52E-5 PDR1 38 4.92E-5
12 SGTC_1919 st067113 3.77 52.3 µM 4.30E-5 TSC3-RPN4 32 8.07E-5
13 SGTC_1838 st055369 3.72 84.5 µM 5.49E-5 24 1.01E-4
14 SGTC_3310 9130229 3.69 44.1 µM 6.25E-5 Golgi 36 1.14E-4
15 SGTC_1695 st026914 3.68 34.5 µM 6.28E-5 26 1.15E-4
16 SGTC_1398 3558-0053 3.49 112.0 µM 1.42E-4 6 2.44E-4
17 SGTC_1276 0871-0068 3.31 94.2 µM 2.88E-4 38 4.70E-4
18 SGTC_3322 9139058 3.29 2.1 µM 3.05E-4 cell wall 53 4.97E-4
19 SGTC_939 1165-0479 3.29 45.3 µM 3.13E-4 64 5.09E-4
20 SGTC_2758 dehydroepiandrosterone 3.28 69.3 µM 3.23E-4 72 5.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.51E-16 YNL194C YNL194C hom Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate
0.117 1.06E-11 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.116 1.93E-11 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.114 4.07E-11 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.109 2.21E-10 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.109 2.41E-10 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.109 2.88E-10 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.099 9.11E-9 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.097 1.80E-8 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.095 3.39E-8 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.093 6.32E-8 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 5.51E-7 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.085 8.21E-7 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.084 1.14E-6 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.084 1.25E-6 YLR226W BUR2 hom Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II