YAR042W / SWH1

Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR042W / SWH1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.80|P-value:2.79E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.45|P-value:1.11E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:1.49E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.12|P-value:4.83E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.44|P-value:1.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.46|P-value:1.25E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:3.35|P-value:1.91E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:2.92|P-value:9.83E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.94|P-value:9.41E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.12|P-value:6.47E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.93|P-value:1.56E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.72|P-value:4.01E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.23|P-value:3.04E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.07|P-value:5.42E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.19|P-value:4.47E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-6.07|P-value:5.75E-11 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.04|P-value:6.35E-4 ID:SGTC_1523|Compound:st012844|FD-Score:6.45|P-value:4.01E-12 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.20|P-value:3.29E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.68|P-value:3.50E-7 ID:SGTC_1700|Compound:st030840|FD-Score:3.74|P-value:3.71E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.39|P-value:1.62E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.81|P-value:2.69E-13 ID:SGTC_1716|Compound:st033144|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_1734|Compound:st037168|FD-Score:7.39|P-value:2.31E-15 ID:SGTC_1754|Compound:st042065|FD-Score:3.55|P-value:8.51E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.75|P-value:2.28E-25 ID:SGTC_1800|Compound:st050079|FD-Score:4.93|P-value:8.81E-8 ID:SGTC_1801|Compound:st050089|FD-Score:8.53|P-value:7.18E-20 ID:SGTC_1803|Compound:st050068|FD-Score:7.54|P-value:6.58E-16 ID:SGTC_1837|Compound:st055472|FD-Score:3.09|P-value:5.28E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.23|P-value:3.11E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.11|P-value:4.89E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.03|P-value:6.64E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.46|P-value:1.25E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.32|P-value:2.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.27|P-value:2.72E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.74|P-value:2.48E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-3.48|P-value:1.07E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.55|P-value:8.39E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.03|P-value:6.55E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.45|P-value:1.24E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.26|P-value:3.26E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.19|P-value:3.64E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.25|P-value:2.87E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.85|P-value:2.24E-5 ID:SGTC_2860|Compound:9025725|FD-Score:2.96|P-value:8.73E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.61|P-value:6.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.83|P-value:2.50E-5 ID:SGTC_3177|Compound:9107506|FD-Score:3.03|P-value:6.66E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.11|P-value:4.71E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.80|P-value:2.79E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.45|P-value:1.11E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:1.49E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.12|P-value:4.83E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.44|P-value:1.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.46|P-value:1.25E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:3.35|P-value:1.91E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:2.92|P-value:9.83E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.94|P-value:9.41E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.12|P-value:6.47E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.93|P-value:1.56E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.72|P-value:4.01E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.23|P-value:3.04E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.07|P-value:5.42E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.19|P-value:4.47E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-6.07|P-value:5.75E-11 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.04|P-value:6.35E-4 ID:SGTC_1523|Compound:st012844|FD-Score:6.45|P-value:4.01E-12 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.20|P-value:3.29E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.68|P-value:3.50E-7 ID:SGTC_1700|Compound:st030840|FD-Score:3.74|P-value:3.71E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.39|P-value:1.62E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.81|P-value:2.69E-13 ID:SGTC_1716|Compound:st033144|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_1734|Compound:st037168|FD-Score:7.39|P-value:2.31E-15 ID:SGTC_1754|Compound:st042065|FD-Score:3.55|P-value:8.51E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.75|P-value:2.28E-25 ID:SGTC_1800|Compound:st050079|FD-Score:4.93|P-value:8.81E-8 ID:SGTC_1801|Compound:st050089|FD-Score:8.53|P-value:7.18E-20 ID:SGTC_1803|Compound:st050068|FD-Score:7.54|P-value:6.58E-16 ID:SGTC_1837|Compound:st055472|FD-Score:3.09|P-value:5.28E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.23|P-value:3.11E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.11|P-value:4.89E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.03|P-value:6.64E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.46|P-value:1.25E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.32|P-value:2.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.27|P-value:2.72E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.74|P-value:2.48E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-3.48|P-value:1.07E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.55|P-value:8.39E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.03|P-value:6.55E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.45|P-value:1.24E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.26|P-value:3.26E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.19|P-value:3.64E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.25|P-value:2.87E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.85|P-value:2.24E-5 ID:SGTC_2860|Compound:9025725|FD-Score:2.96|P-value:8.73E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.61|P-value:6.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.83|P-value:2.50E-5 ID:SGTC_3177|Compound:9107506|FD-Score:3.03|P-value:6.66E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.11|P-value:4.71E-4

Top fitness defect scores for YAR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1760 st045453 9.75 10.4 µM 2.28E-25 NEO1-PIK1 35 9.04E-23
2 SGTC_1801 st050089 8.53 28.4 µM 7.18E-20 NEO1-PIK1 22 7.05E-18
3 SGTC_1803 st050068 7.54 52.4 µM 6.58E-16 NEO1-PIK1 47 2.37E-14
4 SGTC_221 trifluoperazine 7.46 10.3 µM 1.25E-15 NEO1-PIK1 94 4.19E-14
5 SGTC_1734 st037168 7.39 69.4 µM 2.31E-15 2 7.26E-14
6 SGTC_1712 st032288 6.81 53.4 µM 2.69E-13 calcium & mitochondrial duress 57 5.03E-12
7 SGTC_1523 st012844 6.45 44.7 µM 4.01E-12 60S ribosome export 2 5.58E-11
8 SGTC_1800 st050079 4.93 29.1 µM 8.81E-8 NEO1-PIK1 77 4.15E-7
9 SGTC_2257 7960413 4.74 200.0 µM 2.48E-7 NEO1-PIK1 31 1.05E-6
10 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 4.68 19.1 µM 3.50E-7 11 1.42E-6
11 SGTC_2504 purpurogallin 4.26 52.3 µM 3.26E-6 RPP1 & pyrimidine depletion 16 1.04E-5
12 SGTC_1053 3366-3204 4.19 134.0 µM 4.47E-6 cell wall 31 1.39E-5
13 SGTC_599 1935-0052 4.12 86.5 µM 6.47E-6 17 1.93E-5
14 SGTC_967 1306-0166 3.93 352.0 µM 1.56E-5 35 4.25E-5
15 SGTC_2788 5282734 3.85 71.4 µM 2.24E-5 52 5.86E-5
16 SGTC_3037 9091026 3.83 49.5 µM 2.50E-5 NEO1-PIK1 130 6.47E-5
17 SGTC_15 0266-0086 3.80 27.1 µM 2.79E-5 endomembrane recycling 70 7.12E-5
18 SGTC_1700 st030840 3.74 7.9 µM 3.71E-5 PDR1 23 9.20E-5
19 SGTC_1004 4084-0029 3.72 199.0 µM 4.01E-5 21 9.86E-5
20 SGTC_3003 9075612 3.61 71.4 µM 6.60E-5 28 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.481 4.06E-194 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.377 4.54E-114 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.376 7.69E-113 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.366 6.31E-107 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.359 2.05E-102 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.350 4.21E-97 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.344 5.59E-94 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.341 3.13E-92 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.340 1.50E-91 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.337 7.45E-90 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.336 6.04E-89 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.333 6.28E-88 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.332 5.19E-87 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.326 6.51E-84 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.320 8.31E-81 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription