HIPHOP chemogenomics database
YAR047C_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YAR047C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.111 | 1.32E-10 | YBR089C-A | NHP6B | hom | High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication |
| 0.094 | 5.13E-8 | YNL148C | ALF1 | hom | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |
| 0.090 | 1.65E-7 | YOR386W | PHR1 | hom | DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p |
| 0.085 | 7.81E-7 | YOR257W | CDC31 | het | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
| 0.084 | 1.01E-6 | YJL197W | UBP12 | hom | Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm |
| 0.083 | 1.41E-6 | YLR043C | TRX1 | hom | Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress |
| 0.081 | 2.37E-6 | YEL026W | SNU13 | het | RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein |
| 0.080 | 3.20E-6 | YHR095W_d | YHR095W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.080 | 3.67E-6 | YKL181W | PRS1 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
| 0.079 | 4.08E-6 | YOL152W | FRE7 | hom | Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels |
| 0.079 | 4.49E-6 | YIL047C | SYG1 | hom | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency |
| 0.079 | 5.01E-6 | YHL014C | YLF2 | hom | Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.075 | 1.48E-5 | YOR323C | PRO2 | hom | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| 0.075 | 1.51E-5 | YER103W | SSA4 | hom | Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication |
| 0.072 | 3.18E-5 | YFL046W_p | FMP32_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |