YBL001C / ECM15

Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL001C / ECM15

Click on Significant Values for Screen Details ID:SGTC_313|Compound:3474-0040|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.92|P-value:7.49E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.51|P-value:5.41E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:3.64|P-value:4.16E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.97|P-value:8.53E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.06|P-value:4.60E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.94|P-value:7.00E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.90|P-value:8.47E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.19|P-value:2.64E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.23|P-value:2.32E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:6.91E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.90|P-value:8.05E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.44|P-value:9.45E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.37|P-value:1.34E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.53|P-value:6.34E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.02|P-value:6.29E-6 ID:SGTC_1941|Compound:st076221|FD-Score:2.98|P-value:6.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:2.93|P-value:7.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-6.49|P-value:9.48E-13 ID:SGTC_2241|Compound:6772625|FD-Score:-7.34|P-value:8.52E-16 ID:SGTC_2245|Compound:6637752|FD-Score:4.88|P-value:6.35E-8 ID:SGTC_2325|Compound:6158266|FD-Score:-2.90|P-value:8.17E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.47|P-value:6.03E-7 ID:SGTC_2333|Compound:9017922|FD-Score:4.98|P-value:3.46E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.96|P-value:6.79E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.52|P-value:6.61E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:7.46|P-value:3.24E-16 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.74|P-value:1.32E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.93|P-value:7.35E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.57|P-value:5.68E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-2.87|P-value:9.23E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.41|P-value:1.13E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.91|P-value:8.19E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.36|P-value:1.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:6.04E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-2.92|P-value:7.49E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.51|P-value:5.41E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:3.64|P-value:4.16E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.97|P-value:8.53E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.06|P-value:4.60E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.94|P-value:7.00E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.90|P-value:8.47E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.19|P-value:2.64E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.23|P-value:2.32E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:6.91E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.90|P-value:8.05E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.44|P-value:9.45E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.37|P-value:1.34E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.53|P-value:6.34E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.02|P-value:6.29E-6 ID:SGTC_1941|Compound:st076221|FD-Score:2.98|P-value:6.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:2.93|P-value:7.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-6.49|P-value:9.48E-13 ID:SGTC_2241|Compound:6772625|FD-Score:-7.34|P-value:8.52E-16 ID:SGTC_2245|Compound:6637752|FD-Score:4.88|P-value:6.35E-8 ID:SGTC_2325|Compound:6158266|FD-Score:-2.90|P-value:8.17E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.47|P-value:6.03E-7 ID:SGTC_2333|Compound:9017922|FD-Score:4.98|P-value:3.46E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.96|P-value:6.79E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.52|P-value:6.61E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:7.46|P-value:3.24E-16 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.74|P-value:1.32E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.93|P-value:7.35E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.57|P-value:5.68E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-2.87|P-value:9.23E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.41|P-value:1.13E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.91|P-value:8.19E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.36|P-value:1.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:6.04E-4

Top fitness defect scores for YBL001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2578 7,8-dihydroxyflavone 7.46 64.4 µM 3.24E-16 5 4.24E-14
2 SGTC_2333 9017922 4.98 200.0 µM 3.46E-8 14 3.13E-7
3 SGTC_2245 6637752 4.88 200.0 µM 6.35E-8 11 5.26E-7
4 SGTC_593 1203-0218 4.51 61.7 µM 5.41E-7 3 3.30E-6
5 SGTC_1377 2944-0135 4.23 198.0 µM 2.32E-6 calcium & mitochondrial duress 31 1.15E-5
6 SGTC_988 1497-1057 3.97 103.0 µM 8.53E-6 10 3.52E-5
7 SGTC_986 1493-0483 3.64 84.0 µM 4.16E-5 17 1.38E-4
8 SGTC_2692 st077426 3.57 47.7 µM 5.68E-5 30 1.80E-4
9 SGTC_590 k048-0076 3.41 22.4 µM 1.10E-4 RSC & ERG11 23 3.19E-4
10 SGTC_2763 lisinopril 3.41 49.3 µM 1.13E-4 18 3.26E-4
11 SGTC_1924 st058459 3.37 75.1 µM 1.34E-4 24 3.77E-4
12 SGTC_313 3474-0040 3.23 5.0 µM 2.43E-4 NEO1-PIK1 112 6.29E-4
13 SGTC_1927 st060202 3.17 13.8 µM 3.09E-4 47 7.75E-4
14 SGTC_989 1501-0895 3.06 10.3 µM 4.60E-4 25 0.00109
15 SGTC_1941 st076221 2.98 61.8 µM 6.40E-4 sphingolipid biosynthesis & PDR1 146 0.00145
16 SGTC_2572 astragaloside iv 2.96 100.0 µM 6.79E-4 78 0.00153
17 SGTC_2133 5320837 2.93 200.0 µM 7.64E-4 ERG2 77 0.00169
18 SGTC_2898 9056270 2.91 58.4 µM 8.19E-4 28 0.00179
19 SGTC_1211 1056-0033 2.90 32.3 µM 8.47E-4 40 0.00185
20 SGTC_2770 toltrazuril 2.80 17.5 µM 0.00123 85 0.00255

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.43E-42 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.216 6.90E-37 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.212 1.65E-35 YDR109C_p YDR109C_p hom Putative kinase
0.176 7.53E-25 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.167 2.62E-22 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.166 4.24E-22 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.161 7.49E-21 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.149 5.02E-18 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
0.147 8.99E-18 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.146 1.67E-17 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.143 6.60E-17 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.142 1.49E-16 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.141 2.21E-16 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.139 6.12E-16 YJR126C VPS70 hom Protein of unknown function involved in vacuolar protein sorting
0.132 1.69E-14 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose