YBL003C / HTA2

Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL003C / HTA2

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.95|P-value:8.71E-4 ID:SGTC_447|Compound:ml7|FD-Score:-3.63|P-value:4.89E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.77|P-value:2.69E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.05|P-value:7.09E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.97|P-value:1.22E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.06|P-value:5.07E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.61|P-value:5.34E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.21|P-value:2.85E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.13|P-value:4.42E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.93|P-value:6.35E-8 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.82|P-value:2.13E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:2.93|P-value:9.20E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.96|P-value:8.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.02|P-value:4.45E-8 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.48|P-value:9.68E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.63|P-value:5.64E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.27|P-value:2.23E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.56|P-value:6.14E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.10|P-value:4.45E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.98|P-value:1.02E-5 ID:SGTC_2200|Compound:6600604|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.17|P-value:3.79E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.13|P-value:5.57E-6 ID:SGTC_2279|Compound:7948423|FD-Score:5.53|P-value:1.95E-9 ID:SGTC_2342|Compound:7990637|FD-Score:3.42|P-value:1.36E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.48|P-value:9.24E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.63|P-value:5.02E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.96|P-value:8.37E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.01|P-value:6.93E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:6.06|P-value:5.37E-11 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.91|P-value:8.95E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.31|P-value:1.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.17|P-value:3.42E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.37|P-value:1.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.38|P-value:1.42E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.02|P-value:5.95E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.10|P-value:5.67E-6 ID:SGTC_3223|Compound:9129970|FD-Score:4.53|P-value:7.29E-7 ID:SGTC_3244|Compound:9134489|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.95|P-value:8.71E-4 ID:SGTC_447|Compound:ml7|FD-Score:-3.63|P-value:4.89E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.77|P-value:2.69E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.05|P-value:7.09E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.97|P-value:1.22E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.06|P-value:5.07E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.61|P-value:5.34E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.21|P-value:2.85E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.13|P-value:4.42E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.93|P-value:6.35E-8 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.82|P-value:2.13E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:2.93|P-value:9.20E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.96|P-value:8.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.02|P-value:4.45E-8 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.48|P-value:9.68E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.63|P-value:5.64E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.27|P-value:2.23E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.56|P-value:6.14E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.10|P-value:4.45E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.98|P-value:1.02E-5 ID:SGTC_2200|Compound:6600604|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.17|P-value:3.79E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.13|P-value:5.57E-6 ID:SGTC_2279|Compound:7948423|FD-Score:5.53|P-value:1.95E-9 ID:SGTC_2342|Compound:7990637|FD-Score:3.42|P-value:1.36E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.48|P-value:9.24E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.63|P-value:5.02E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.96|P-value:8.37E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.01|P-value:6.93E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:6.06|P-value:5.37E-11 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.91|P-value:8.95E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.31|P-value:1.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.17|P-value:3.42E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.37|P-value:1.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.38|P-value:1.42E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.02|P-value:5.95E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.10|P-value:5.67E-6 ID:SGTC_3223|Compound:9129970|FD-Score:4.53|P-value:7.29E-7 ID:SGTC_3244|Compound:9134489|FD-Score:-3.26|P-value:2.34E-4

Top fitness defect scores for YBL003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 6.06 100.0 µM 5.37E-11 9 6.79E-10
2 SGTC_2279 7948423 5.53 32.9 µM 1.95E-9 4 1.61E-8
3 SGTC_1134 3477-0009 5.02 42.5 µM 4.45E-8 20 2.55E-7
4 SGTC_1436 4092-1007 4.56 8.3 µM 6.14E-7 6 2.59E-6
5 SGTC_3223 9129970 4.53 49.5 µM 7.29E-7 14 3.01E-6
6 SGTC_2410 aloe-emodin-8-o-glycoside 4.48 46.3 µM 9.24E-7 mitochondrial processes 15 3.72E-6
7 SGTC_2277 7947813 4.13 106.9 µM 5.57E-6 RSC complex & mRNA processing 24 1.82E-5
8 SGTC_270 tamoxifen 4.00 5.5 µM 1.06E-5 NEO1 24 3.22E-5
9 SGTC_591 4299-0174 3.97 154.0 µM 1.22E-5 9 3.64E-5
10 SGTC_149 3970-0822 3.89 46.1 µM 1.75E-5 tubulin folding & SWR complex 101 5.02E-5
11 SGTC_1330 1469-0054 3.63 61.8 µM 5.64E-5 iron homeostasis 25 1.42E-4
12 SGTC_2342 7990637 3.42 118.9 µM 1.36E-4 RNA processing & uracil transport 60 3.08E-4
13 SGTC_2462 5162487 3.32 171.8 µM 2.11E-4 33 4.56E-4
14 SGTC_2260 7964312 3.17 200.0 µM 3.79E-4 38 7.66E-4
15 SGTC_634 1611-4317 3.13 11.2 µM 4.42E-4 ERG2 44 8.79E-4
16 SGTC_2454 5-benzylidenerhodanine 3.09 10.4 µM 5.06E-4 TRP & mitochondrial translation 84 9.91E-4
17 SGTC_2615 purpurogallin-4-carboxylic acid 3.01 100.0 µM 6.93E-4 redox potentiating 123 0.00131
18 SGTC_677 0929-0063 2.98 136.0 µM 7.78E-4 42 0.00145
19 SGTC_1377 2944-0135 2.97 198.0 µM 8.01E-4 calcium & mitochondrial duress 94 0.00149
20 SGTC_1129 3453-1384 2.96 223.0 µM 8.34E-4 94 0.00155

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.48E-15 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.129 6.00E-14 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.122 1.12E-12 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.105 1.19E-9 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.103 2.16E-9 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.099 9.67E-9 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.095 3.81E-8 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.088 2.87E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.086 6.51E-7 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.085 8.45E-7 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.083 1.55E-6 YAL046C AIM1 hom Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
0.082 1.98E-6 YOR346W REV1 hom Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.078 5.45E-6 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.078 5.91E-6 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.077 8.35E-6 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate