YBL005W / PDR3

Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL005W / PDR3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.86|P-value:7.67E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:4.42|P-value:5.56E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.95|P-value:4.32E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:5.18|P-value:1.32E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:4.76|P-value:1.10E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:3.17|P-value:8.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.01|P-value:1.22E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.01|P-value:3.29E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-4.92|P-value:6.76E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.76|P-value:9.14E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:7.38|P-value:1.29E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:13.90|P-value:1.74E-43 ID:SGTC_539|Compound:4859-0462|FD-Score:4.79|P-value:9.65E-7 ID:SGTC_644|Compound:1498-1197|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.88|P-value:5.75E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.52|P-value:2.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.78|P-value:1.38E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.18|P-value:7.55E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.76|P-value:8.98E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.87|P-value:5.77E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.65|P-value:1.90E-6 ID:SGTC_1861|Compound:st057647|FD-Score:-3.48|P-value:3.20E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.26|P-value:5.87E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.41|P-value:3.42E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.33|P-value:4.55E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.76|P-value:1.10E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-3.26|P-value:6.96E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.30|P-value:5.12E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.52|P-value:2.84E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.12|P-value:2.68E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.68|P-value:2.21E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.40|P-value:4.37E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.83|P-value:6.97E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.56|P-value:1.93E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.11|P-value:9.53E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_3005|Compound:9076496|FD-Score:4.61|P-value:2.31E-6 ID:SGTC_3206|Compound:9114350|FD-Score:3.26|P-value:5.85E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.12|P-value:2.06E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.90|P-value:5.68E-7 ID:SGTC_3301|Compound:9125354|FD-Score:3.32|P-value:4.77E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.63|P-value:1.49E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.86|P-value:7.67E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:4.42|P-value:5.56E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.95|P-value:4.32E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:5.18|P-value:1.32E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:4.76|P-value:1.10E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:3.17|P-value:8.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.01|P-value:1.22E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.01|P-value:3.29E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-4.92|P-value:6.76E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.76|P-value:9.14E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:7.38|P-value:1.29E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:13.90|P-value:1.74E-43 ID:SGTC_539|Compound:4859-0462|FD-Score:4.79|P-value:9.65E-7 ID:SGTC_644|Compound:1498-1197|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.88|P-value:5.75E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.52|P-value:2.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.78|P-value:1.38E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.18|P-value:7.55E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.76|P-value:8.98E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.87|P-value:5.77E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.65|P-value:1.90E-6 ID:SGTC_1861|Compound:st057647|FD-Score:-3.48|P-value:3.20E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.26|P-value:5.87E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.41|P-value:3.42E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.33|P-value:4.55E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.76|P-value:1.10E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-3.26|P-value:6.96E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.30|P-value:5.12E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.52|P-value:2.84E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.12|P-value:2.68E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.68|P-value:2.21E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.40|P-value:4.37E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.83|P-value:6.97E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.56|P-value:1.93E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.11|P-value:9.53E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_3005|Compound:9076496|FD-Score:4.61|P-value:2.31E-6 ID:SGTC_3206|Compound:9114350|FD-Score:3.26|P-value:5.85E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.12|P-value:2.06E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.90|P-value:5.68E-7 ID:SGTC_3301|Compound:9125354|FD-Score:3.32|P-value:4.77E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.63|P-value:1.49E-4

Top fitness defect scores for YBL005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 13.90 10.0 µM 1.74E-43 3 2.43E-44
2 SGTC_439 amiodarone 7.38 34.4 µM 1.29E-13 NEO1-PIK1 27 8.16E-14
3 SGTC_310 1273-0058 6.01 1.1 µM 1.22E-9 mitochondrial stress 145 9.27E-10
4 SGTC_127 0180-0333 5.18 59.1 µM 1.32E-7 mitochondrial response to ROS 14 1.10E-7
5 SGTC_3223 9129970 4.90 49.5 µM 5.68E-7 11 4.85E-7
6 SGTC_539 4859-0462 4.79 2.5 µM 9.65E-7 RNA pol III & RNase P/MRP 7 8.32E-7
7 SGTC_2131 toluylene red 4.76 5.3 µM 1.10E-6 60S ribosome export 6 9.53E-7
8 SGTC_173 1273-0061 4.76 2.7 µM 1.10E-6 mitochondrial stress 159 9.54E-7
9 SGTC_1853 st056710 4.65 91.2 µM 1.90E-6 amide catabolism 12 1.66E-6
10 SGTC_3005 9076496 4.61 71.4 µM 2.31E-6 3 2.02E-6
11 SGTC_22 0964-0034 4.42 14.5 µM 5.56E-6 unfolded protein response 39 4.94E-6
12 SGTC_3220 9131269 4.12 49.5 µM 2.06E-5 8 1.88E-5
13 SGTC_410 α-linolenic acid 4.01 100.0 µM 3.29E-5 excess fatty acid 39 3.02E-5
14 SGTC_124 0136-0217 3.95 7.1 µM 4.32E-5 mitochondrial stress 57 3.98E-5
15 SGTC_652 0437-0092 3.88 114.0 µM 5.75E-5 19 5.33E-5
16 SGTC_1787 fluconazole 3.87 80.0 µM 5.77E-5 iron homeostasis 25 5.34E-5
17 SGTC_2939 9044578 3.83 71.4 µM 6.97E-5 45 6.48E-5
18 SGTC_1780 st038448 3.76 24.5 µM 8.98E-5 iron homeostasis 24 8.37E-5
19 SGTC_421 streptovitacin 3.76 30.0 mM 9.14E-5 26 8.53E-5
20 SGTC_1852 st056254 3.69 31.4 µM 1.18E-4 14 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 3.81E-57 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.191 4.68E-29 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.187 1.22E-27 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.163 1.76E-21 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.150 1.95E-18 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.148 5.65E-18 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.148 6.57E-18 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.137 1.47E-15 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.136 2.25E-15 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.134 6.37E-15 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.134 6.81E-15 YLL020C_d YLL020C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.133 9.53E-15 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.128 8.88E-14 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.128 1.26E-13 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.127 1.87E-13 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription