YBL007C / SLA1

Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL007C / SLA1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:9.47|P-value:8.41E-15 ID:SGTC_19|Compound:0279-0214|FD-Score:4.49|P-value:1.43E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.01|P-value:5.99E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:9.97|P-value:3.09E-16 ID:SGTC_98|Compound:0074-0023|FD-Score:6.25|P-value:2.13E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.21|P-value:3.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.65|P-value:7.16E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:8.93|P-value:2.37E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:4.54|P-value:1.24E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.02|P-value:2.51E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.80|P-value:1.27E-33 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.07|P-value:5.06E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.80|P-value:1.01E-15 ID:SGTC_279|Compound:1273-0055|FD-Score:4.88|P-value:4.01E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.04|P-value:3.70E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.43|P-value:1.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.05|P-value:5.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.96|P-value:5.54E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.40|P-value:1.57E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.03|P-value:2.42E-5 ID:SGTC_500|Compound:h-89|FD-Score:4.02|P-value:5.86E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:7.91|P-value:7.59E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.45|P-value:6.82E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:-5.54|P-value:2.95E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:6.09|P-value:4.18E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:4.20|P-value:3.44E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.63|P-value:9.13E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:10.80|P-value:9.22E-19 ID:SGTC_791|Compound:1348-1292|FD-Score:8.88|P-value:3.17E-13 ID:SGTC_800|Compound:3448-7362|FD-Score:10.50|P-value:6.17E-18 ID:SGTC_830|Compound:4076-0286|FD-Score:4.18|P-value:3.65E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.18|P-value:3.65E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:5.55|P-value:3.65E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:7.99|P-value:4.82E-11 ID:SGTC_997|Compound:3996-0078|FD-Score:4.72|P-value:6.91E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-4.13|P-value:3.64E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:5.28|P-value:9.81E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:5.70|P-value:1.99E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:6.43|P-value:9.60E-8 ID:SGTC_1186|Compound:1319-0216|FD-Score:6.01|P-value:5.78E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.84|P-value:1.53E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:5.53|P-value:3.83E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.24|P-value:3.07E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.18|P-value:3.74E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.20|P-value:3.51E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.90|P-value:8.20E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:5.24|P-value:1.14E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.19|P-value:2.90E-9 ID:SGTC_1623|Compound:st003709|FD-Score:4.51|P-value:1.34E-4 ID:SGTC_1627|Compound:st003713|FD-Score:6.98|P-value:7.90E-9 ID:SGTC_1635|Compound:st007035|FD-Score:12.40|P-value:6.29E-24 ID:SGTC_1658|Compound:st012944|FD-Score:-5.61|P-value:2.31E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-6.50|P-value:5.58E-8 ID:SGTC_1672|Compound:st016598|FD-Score:7.29|P-value:1.74E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.29|P-value:7.60E-6 ID:SGTC_1742|Compound:st038235|FD-Score:5.87|P-value:1.00E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.90|P-value:8.16E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.78|P-value:9.67E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.06|P-value:5.19E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.52|P-value:1.31E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.85|P-value:7.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.37|P-value:2.09E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.28|P-value:2.73E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.13|P-value:1.66E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.02|P-value:5.83E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.21|P-value:1.26E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.91|P-value:6.89E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.50|P-value:3.71E-32 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.24|P-value:2.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.10|P-value:3.95E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.32|P-value:2.04E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.89|P-value:7.30E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.11|P-value:4.57E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.24|P-value:2.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.01|P-value:5.07E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.55|P-value:1.17E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.63|P-value:2.60E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.83|P-value:8.58E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.51|P-value:5.39E-8 ID:SGTC_3018|Compound:9082602|FD-Score:4.64|P-value:8.98E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-4.65|P-value:7.01E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:9.47|P-value:8.41E-15 ID:SGTC_19|Compound:0279-0214|FD-Score:4.49|P-value:1.43E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.01|P-value:5.99E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:9.97|P-value:3.09E-16 ID:SGTC_98|Compound:0074-0023|FD-Score:6.25|P-value:2.13E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.21|P-value:3.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.65|P-value:7.16E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:8.93|P-value:2.37E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:4.54|P-value:1.24E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.02|P-value:2.51E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.80|P-value:1.27E-33 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.07|P-value:5.06E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.80|P-value:1.01E-15 ID:SGTC_279|Compound:1273-0055|FD-Score:4.88|P-value:4.01E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.04|P-value:3.70E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.43|P-value:1.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.05|P-value:5.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.96|P-value:5.54E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.40|P-value:1.57E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.03|P-value:2.42E-5 ID:SGTC_500|Compound:h-89|FD-Score:4.02|P-value:5.86E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:7.91|P-value:7.59E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.45|P-value:6.82E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:-5.54|P-value:2.95E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:6.09|P-value:4.18E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:4.20|P-value:3.44E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.63|P-value:9.13E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:10.80|P-value:9.22E-19 ID:SGTC_791|Compound:1348-1292|FD-Score:8.88|P-value:3.17E-13 ID:SGTC_800|Compound:3448-7362|FD-Score:10.50|P-value:6.17E-18 ID:SGTC_830|Compound:4076-0286|FD-Score:4.18|P-value:3.65E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.18|P-value:3.65E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:5.55|P-value:3.65E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:7.99|P-value:4.82E-11 ID:SGTC_997|Compound:3996-0078|FD-Score:4.72|P-value:6.91E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-4.13|P-value:3.64E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:5.28|P-value:9.81E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:5.70|P-value:1.99E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:6.43|P-value:9.60E-8 ID:SGTC_1186|Compound:1319-0216|FD-Score:6.01|P-value:5.78E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.84|P-value:1.53E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:5.53|P-value:3.83E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.24|P-value:3.07E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.18|P-value:3.74E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.20|P-value:3.51E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.90|P-value:8.20E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:5.24|P-value:1.14E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.19|P-value:2.90E-9 ID:SGTC_1623|Compound:st003709|FD-Score:4.51|P-value:1.34E-4 ID:SGTC_1627|Compound:st003713|FD-Score:6.98|P-value:7.90E-9 ID:SGTC_1635|Compound:st007035|FD-Score:12.40|P-value:6.29E-24 ID:SGTC_1658|Compound:st012944|FD-Score:-5.61|P-value:2.31E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-6.50|P-value:5.58E-8 ID:SGTC_1672|Compound:st016598|FD-Score:7.29|P-value:1.74E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.29|P-value:7.60E-6 ID:SGTC_1742|Compound:st038235|FD-Score:5.87|P-value:1.00E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.90|P-value:8.16E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.78|P-value:9.67E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.06|P-value:5.19E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.52|P-value:1.31E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.85|P-value:7.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.37|P-value:2.09E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.28|P-value:2.73E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.13|P-value:1.66E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.02|P-value:5.83E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.21|P-value:1.26E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.91|P-value:6.89E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.50|P-value:3.71E-32 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.24|P-value:2.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.10|P-value:3.95E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.32|P-value:2.04E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.89|P-value:7.30E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.11|P-value:4.57E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.24|P-value:2.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.01|P-value:5.07E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.55|P-value:1.17E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.63|P-value:2.60E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.83|P-value:8.58E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.51|P-value:5.39E-8 ID:SGTC_3018|Compound:9082602|FD-Score:4.64|P-value:8.98E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-4.65|P-value:7.01E-5

Top fitness defect scores for YBL007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.80 5.3 µM 1.27E-33 103 5.18E-50
2 SGTC_2582 agaric acid 14.50 100.0 µM 3.71E-32 redox potentiating 19 8.56E-48
3 SGTC_1635 st007035 12.40 42.4 µM 6.29E-24 55 2.37E-35
4 SGTC_788 1182-0090 10.80 188.0 µM 9.22E-19 endomembrane recycling 11 1.51E-27
5 SGTC_800 3448-7362 10.50 155.0 µM 6.17E-18 translation 3 2.68E-26
6 SGTC_63 0099-0242 9.97 26.7 µM 3.09E-16 mitochondrial stress 1 9.87E-24
7 SGTC_275 trichlorophene 9.80 5.7 µM 1.01E-15 mitochondrial stress 47 5.89E-23
8 SGTC_10 0279-0212 9.47 42.6 µM 8.41E-15 TRP & mitochondrial translation 4 1.45E-21
9 SGTC_157 1348-1695 8.93 65.8 µM 2.37E-13 iron homeostasis 13 2.23E-19
10 SGTC_791 1348-1292 8.88 225.0 µM 3.17E-13 1 3.46E-19
11 SGTC_310 1273-0058 8.04 1.1 µM 3.70E-11 mitochondrial stress 87 4.52E-16
12 SGTC_995 3931-2021 7.99 34.6 µM 4.82E-11 RPP1 & pyrimidine depletion 3 6.73E-16
13 SGTC_502 l-744,832 7.91 89.3 µM 7.59E-11 calcium & mitochondrial duress 7 1.33E-15
14 SGTC_1672 st016598 7.29 6.5 µM 1.74E-9 endomembrane recycling 21 1.50E-13
15 SGTC_1597 7-benzyloxygramine 7.19 47.5 µM 2.90E-9 calcium & mitochondrial duress 34 3.22E-13
16 SGTC_1627 st003713 6.98 25.6 µM 7.90E-9 calcium & mitochondrial duress 19 1.46E-12
17 SGTC_1188 1403-0014 6.84 4.6 µM 1.53E-8 mitochondrial stress 11 3.94E-12
18 SGTC_1182 1222-0449 6.43 220.0 µM 9.60E-8 2 6.23E-11
19 SGTC_98 0074-0023 6.25 107.7 µM 2.13E-7 Golgi 11 2.06E-10
20 SGTC_2615 purpurogallin-4-carboxylic acid 6.10 100.0 µM 3.95E-7 redox potentiating 26 5.22E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 1.06E-131 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.368 1.19E-107 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.364 3.12E-105 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.362 4.20E-104 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.360 1.19E-102 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.360 9.55E-103 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.357 8.50E-101 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.356 3.67E-100 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.355 1.42E-99 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.354 1.66E-99 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.353 8.52E-99 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.348 1.15E-95 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.342 2.06E-92 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.341 5.79E-92 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.334 6.94E-88 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport