YBL008W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL008W-A / YBL008W-A

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.93|P-value:2.92E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.72|P-value:7.14E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.23|P-value:4.86E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.55|P-value:7.03E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:5.10|P-value:9.35E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.15|P-value:1.11E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:7.86|P-value:5.05E-16 ID:SGTC_427|Compound:1354-0053|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-4.53|P-value:2.02E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.78|P-value:6.03E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.24|P-value:4.54E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.16|P-value:6.44E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.22|P-value:4.98E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:6.65|P-value:5.69E-12 ID:SGTC_840|Compound:0245-0196|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.71|P-value:7.46E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.12|P-value:7.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.79|P-value:5.39E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.27|P-value:4.07E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.67|P-value:8.89E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.67|P-value:9.31E-7 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.74|P-value:6.44E-7 ID:SGTC_1917|Compound:st066507|FD-Score:3.31|P-value:3.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.36|P-value:4.26E-6 ID:SGTC_1986|Compound:st071812|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.11|P-value:1.33E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.15|P-value:6.37E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-3.12|P-value:7.54E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.88|P-value:3.65E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.16|P-value:6.05E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.14|P-value:6.68E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.23|P-value:4.81E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.07|P-value:9.01E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.45|P-value:2.26E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.11|P-value:9.07E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:3.42|P-value:2.38E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.45|P-value:2.68E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-3.16|P-value:6.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.47|P-value:1.95E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.17|P-value:6.33E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.86|P-value:1.08E-9 ID:SGTC_2820|Compound:7989630|FD-Score:7.94|P-value:2.47E-16 ID:SGTC_2828|Compound:7998861|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.47|P-value:1.91E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.90|P-value:3.54E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.30|P-value:3.97E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.12|P-value:7.40E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.62|P-value:1.18E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.72|P-value:7.20E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.62|P-value:1.08E-4 ID:SGTC_3244|Compound:9134489|FD-Score:5.07|P-value:1.11E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.92|P-value:3.27E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.93|P-value:2.92E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.72|P-value:7.14E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:3.23|P-value:4.86E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.55|P-value:7.03E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:5.10|P-value:9.35E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.15|P-value:1.11E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:7.86|P-value:5.05E-16 ID:SGTC_427|Compound:1354-0053|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-4.53|P-value:2.02E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.78|P-value:6.03E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.24|P-value:4.54E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.16|P-value:6.44E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.22|P-value:4.98E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:6.65|P-value:5.69E-12 ID:SGTC_840|Compound:0245-0196|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.71|P-value:7.46E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.12|P-value:7.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.79|P-value:5.39E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.27|P-value:4.07E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.22|P-value:4.95E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.67|P-value:8.89E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.67|P-value:9.31E-7 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.74|P-value:6.44E-7 ID:SGTC_1917|Compound:st066507|FD-Score:3.31|P-value:3.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.36|P-value:4.26E-6 ID:SGTC_1986|Compound:st071812|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.11|P-value:1.33E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.15|P-value:6.37E-4 ID:SGTC_2195|Compound:6536160|FD-Score:-3.12|P-value:7.54E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.88|P-value:3.65E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.16|P-value:6.05E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.12|P-value:7.00E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.14|P-value:6.68E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.23|P-value:4.81E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.07|P-value:9.01E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.45|P-value:2.26E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.11|P-value:9.07E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:3.42|P-value:2.38E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.45|P-value:2.68E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-3.16|P-value:6.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.47|P-value:1.95E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.17|P-value:6.33E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.86|P-value:1.08E-9 ID:SGTC_2820|Compound:7989630|FD-Score:7.94|P-value:2.47E-16 ID:SGTC_2828|Compound:7998861|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.47|P-value:1.91E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.90|P-value:3.54E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.30|P-value:3.97E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.12|P-value:7.40E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.62|P-value:1.18E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.72|P-value:7.20E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.62|P-value:1.08E-4 ID:SGTC_3244|Compound:9134489|FD-Score:5.07|P-value:1.11E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.92|P-value:3.27E-5

Top fitness defect scores for YBL008W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2820 7989630 7.94 71.4 µM 2.47E-16 ERG2 2 9.73E-16
2 SGTC_421 streptovitacin 7.86 30.0 mM 5.05E-16 1 1.93E-15
3 SGTC_704 1310-0270 6.65 142.0 µM 5.69E-12 5 1.51E-11
4 SGTC_2769 toremifene 5.86 3.7 µM 1.08E-9 3 2.34E-9
5 SGTC_145 3737-0113 5.55 38.4 µM 7.03E-9 DNA intercalators 34 1.41E-8
6 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 5.11 15.3 µM 9.07E-8 14 1.64E-7
7 SGTC_184 1494-0393 5.10 24.7 µM 9.35E-8 29 1.69E-7
8 SGTC_3244 9134489 5.07 49.5 µM 1.11E-7 8 1.99E-7
9 SGTC_1878 temozolomide 4.74 1.0 mM 6.44E-7 3 1.08E-6
10 SGTC_1635 st007035 4.67 42.4 µM 9.31E-7 178 1.54E-6
11 SGTC_2981 9013952 4.62 39.0 µM 1.18E-6 27 1.93E-6
12 SGTC_2690 usnic acid 4.45 100.0 µM 2.68E-6 18 4.25E-6
13 SGTC_1926 methyl fluorone black 4.36 53.6 µM 4.26E-6 DNA intercalators 49 6.63E-6
14 SGTC_236 1509-0011 4.15 5.3 µM 1.11E-5 371 1.67E-5
15 SGTC_2069 5228469 4.11 200.0 µM 1.33E-5 10 1.98E-5
16 SGTC_143 4032-1194 4.02 15.7 µM 1.97E-5 63 2.89E-5
17 SGTC_115 0527-0192 3.93 112.0 µM 2.92E-5 70 4.21E-5
18 SGTC_2213 7173844 3.88 200.0 µM 3.65E-5 14 5.22E-5
19 SGTC_1360 1598-0022 3.79 39.8 µM 5.39E-5 ERG2 36 7.60E-5
20 SGTC_131 0141-0277 3.72 33.9 µM 7.14E-5 45 9.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 6.25E-39 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.211 3.60E-35 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.200 2.00E-31 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.196 2.42E-30 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.193 1.53E-29 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.157 5.29E-20 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.155 1.97E-19 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.144 6.39E-17 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.142 1.59E-16 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.140 4.22E-16 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.140 4.70E-16 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.139 5.90E-16 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.138 1.06E-15 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.137 1.87E-15 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.137 1.82E-15 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1