YBL011W / SCT1

Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL011W / SCT1

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.26|P-value:7.50E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.96|P-value:4.50E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.78|P-value:9.36E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.15|P-value:1.89E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.41|P-value:4.42E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.46|P-value:3.69E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.23|P-value:7.01E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.21|P-value:1.65E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.63|P-value:1.67E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.22|P-value:8.66E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.22|P-value:8.43E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.45|P-value:3.93E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.05|P-value:3.23E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.70|P-value:9.86E-9 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.57|P-value:3.27E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.30|P-value:1.10E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.14|P-value:9.36E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.33|P-value:4.96E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.46|P-value:3.15E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.17|P-value:8.53E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.35|P-value:6.49E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.86|P-value:6.81E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.99|P-value:4.21E-7 ID:SGTC_2290|Compound:7904846|FD-Score:4.48|P-value:4.94E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.28|P-value:6.89E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.14|P-value:9.41E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.33|P-value:7.29E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.84|P-value:8.98E-5 ID:SGTC_2845|Compound:9003024|FD-Score:7.02|P-value:2.28E-12 ID:SGTC_2903|Compound:5923464|FD-Score:3.27|P-value:6.00E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.27|P-value:6.13E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.17|P-value:8.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.18|P-value:1.64E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.26|P-value:7.50E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.96|P-value:4.50E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.78|P-value:9.36E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.15|P-value:1.89E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.41|P-value:4.42E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.46|P-value:3.69E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.23|P-value:7.01E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.21|P-value:1.65E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.63|P-value:1.67E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.22|P-value:8.66E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.22|P-value:8.43E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.45|P-value:3.93E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.05|P-value:3.23E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.70|P-value:9.86E-9 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.57|P-value:3.27E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.30|P-value:1.10E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.14|P-value:9.36E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.33|P-value:4.96E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.46|P-value:3.15E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.17|P-value:8.53E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.35|P-value:6.49E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.80|P-value:8.76E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.86|P-value:6.81E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.44|P-value:3.34E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.99|P-value:4.21E-7 ID:SGTC_2290|Compound:7904846|FD-Score:4.48|P-value:4.94E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.28|P-value:6.89E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.14|P-value:9.41E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.33|P-value:7.29E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.84|P-value:8.98E-5 ID:SGTC_2845|Compound:9003024|FD-Score:7.02|P-value:2.28E-12 ID:SGTC_2903|Compound:5923464|FD-Score:3.27|P-value:6.00E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.27|P-value:6.13E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.17|P-value:8.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.18|P-value:1.64E-7

Top fitness defect scores for YBL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2845 9003024 7.02 43.0 µM 2.28E-12 amide catabolism 9 1.08E-12
2 SGTC_1162 k048-0130 5.70 20.1 µM 9.86E-9 Golgi 8 6.17E-9
3 SGTC_1513 0337-0559 5.35 19.0 µM 6.49E-8 3 4.32E-8
4 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.33 100.0 µM 7.29E-8 15 4.87E-8
5 SGTC_3305 9127027 5.18 53.8 µM 1.64E-7 7 1.12E-7
6 SGTC_272 doxorubicin 5.15 8.1 µM 1.89E-7 anthracycline transcription coupled DNA repair 8 1.30E-7
7 SGTC_1939 st074455 4.99 53.6 µM 4.21E-7 12 2.97E-7
8 SGTC_1163 k060-0048 4.57 49.9 µM 3.27E-6 13 2.46E-6
9 SGTC_2290 7904846 4.48 200.0 µM 4.94E-6 12 3.77E-6
10 SGTC_2770 toltrazuril 4.31 17.5 µM 1.06E-5 16 8.27E-6
11 SGTC_1243 0416-0003 4.30 5.7 µM 1.10E-5 PDR1 20 8.61E-6
12 SGTC_682 0kpi-0099 4.21 17.0 µM 1.65E-5 60 1.30E-5
13 SGTC_2563 tomatine 4.18 8.5 µM 1.84E-5 38 1.46E-5
14 SGTC_1155 4088-0394 4.05 48.2 µM 3.23E-5 25 2.61E-5
15 SGTC_1029 k015-0030 4.00 64.7 µM 3.84E-5 26 3.12E-5
16 SGTC_255 tunicamycin 3.96 200.5 nM 4.50E-5 unfolded protein response 73 3.67E-5
17 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.86 54.9 µM 6.81E-5 redox potentiating 58 5.63E-5
18 SGTC_1527 coumarin 3.80 137.0 µM 8.76E-5 29 7.30E-5
19 SGTC_271 rotenone 3.78 740.0 µM 9.36E-5 29 7.81E-5
20 SGTC_743 1275-0778 3.75 158.0 µM 1.07E-4 excess fatty acid 39 8.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.55E-11 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.103 2.58E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.099 8.10E-9 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.097 2.12E-8 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.095 3.35E-8 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.092 9.19E-8 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.087 4.05E-7 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.086 5.82E-7 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.081 2.73E-6 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.080 3.80E-6 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.96E-6 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.078 5.46E-6 YNL141W AAH1 hom Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.078 5.91E-6 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.077 8.80E-6 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.077 8.93E-6 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate