YBL012C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL012C / YBL012C

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:5.02|P-value:2.59E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.14|P-value:1.80E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:7.79|P-value:3.31E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:7.23|P-value:2.48E-13 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.15|P-value:8.03E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.37|P-value:3.78E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.33|P-value:7.36E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:3.53|P-value:2.08E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:8.80|P-value:6.94E-19 ID:SGTC_628|Compound:1636-0253|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.16|P-value:8.00E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.19|P-value:7.16E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.74|P-value:1.08E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:4.15|P-value:1.66E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:4.27|P-value:9.76E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:3.79|P-value:7.59E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.14|P-value:8.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.55|P-value:2.70E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.19|P-value:7.11E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.18|P-value:7.27E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.88|P-value:2.10E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.10|P-value:9.69E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.67|P-value:7.05E-9 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.58|P-value:1.70E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.15|P-value:8.11E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:6.08|P-value:6.19E-10 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.22|P-value:6.38E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.11|P-value:1.98E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.10|P-value:9.66E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.89|P-value:4.99E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.11|P-value:9.24E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.31|P-value:8.42E-6 ID:SGTC_2125|Compound:5246583|FD-Score:5.06|P-value:2.12E-7 ID:SGTC_2135|Compound:5326629|FD-Score:5.61|P-value:1.00E-8 ID:SGTC_2213|Compound:7173844|FD-Score:3.16|P-value:7.88E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.11|P-value:9.36E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.26|P-value:5.59E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.42|P-value:3.13E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.92|P-value:4.38E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.76|P-value:8.35E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.41|P-value:3.24E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.03|P-value:2.49E-7 ID:SGTC_2430|Compound:5571206|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.20|P-value:6.76E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.82|P-value:6.71E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.61|P-value:1.52E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.14|P-value:8.39E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.09|P-value:9.93E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.84|P-value:6.36E-7 ID:SGTC_2964|Compound:9083345|FD-Score:4.99|P-value:3.07E-7 ID:SGTC_2971|Compound:9092186|FD-Score:4.94|P-value:3.96E-7 ID:SGTC_3015|Compound:9080845|FD-Score:3.20|P-value:6.94E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.42|P-value:3.14E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-4.62|P-value:1.94E-6 ID:SGTC_3049|Compound:9092223|FD-Score:4.73|P-value:1.13E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.48|P-value:3.68E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.47|P-value:2.59E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.70|P-value:1.34E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.27|P-value:5.39E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.83|P-value:6.31E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:5.02|P-value:2.59E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.14|P-value:1.80E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:7.79|P-value:3.31E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:7.23|P-value:2.48E-13 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.15|P-value:8.03E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.37|P-value:3.78E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.33|P-value:7.36E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:3.53|P-value:2.08E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:8.80|P-value:6.94E-19 ID:SGTC_628|Compound:1636-0253|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.16|P-value:8.00E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.19|P-value:7.16E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.74|P-value:1.08E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:4.15|P-value:1.66E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:4.27|P-value:9.76E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:3.79|P-value:7.59E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.14|P-value:8.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.55|P-value:2.70E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.19|P-value:7.11E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.18|P-value:7.27E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.88|P-value:2.10E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.10|P-value:9.69E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.67|P-value:7.05E-9 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.58|P-value:1.70E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.15|P-value:8.11E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:6.08|P-value:6.19E-10 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.22|P-value:6.38E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.11|P-value:1.98E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.10|P-value:9.66E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.89|P-value:4.99E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.11|P-value:9.24E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.31|P-value:8.42E-6 ID:SGTC_2125|Compound:5246583|FD-Score:5.06|P-value:2.12E-7 ID:SGTC_2135|Compound:5326629|FD-Score:5.61|P-value:1.00E-8 ID:SGTC_2213|Compound:7173844|FD-Score:3.16|P-value:7.88E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.11|P-value:9.36E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.26|P-value:5.59E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.42|P-value:3.13E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.92|P-value:4.38E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.76|P-value:8.35E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.41|P-value:3.24E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.03|P-value:2.49E-7 ID:SGTC_2430|Compound:5571206|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.20|P-value:6.76E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.82|P-value:6.71E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.61|P-value:1.52E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.14|P-value:8.39E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.09|P-value:9.93E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.84|P-value:6.36E-7 ID:SGTC_2964|Compound:9083345|FD-Score:4.99|P-value:3.07E-7 ID:SGTC_2971|Compound:9092186|FD-Score:4.94|P-value:3.96E-7 ID:SGTC_3015|Compound:9080845|FD-Score:3.20|P-value:6.94E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.42|P-value:3.14E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-4.62|P-value:1.94E-6 ID:SGTC_3049|Compound:9092223|FD-Score:4.73|P-value:1.13E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.48|P-value:3.68E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.47|P-value:2.59E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.70|P-value:1.34E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.27|P-value:5.39E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.83|P-value:6.31E-5

Top fitness defect scores for YBL012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_619 1652-1634 8.80 108.0 µM 6.94E-19 PDR1 1 6.76E-19
2 SGTC_184 1494-0393 7.79 24.7 µM 3.31E-15 9 3.25E-15
3 SGTC_363 0455-0021 7.23 3.1 µM 2.48E-13 azole & statin 20 2.44E-13
4 SGTC_1345 1488-0192 6.08 31.4 µM 6.19E-10 3 6.13E-10
5 SGTC_1128 3448-9350 5.88 235.0 µM 2.10E-9 6 2.08E-9
6 SGTC_1178 0988-0033 5.67 191.0 µM 7.05E-9 5 6.99E-9
7 SGTC_2135 5326629 5.61 150.4 µM 1.00E-8 RPP1 & pyrimidine depletion 5 9.94E-9
8 SGTC_2125 5246583 5.06 200.0 µM 2.12E-7 tubulin folding & SWR complex 25 2.11E-7
9 SGTC_2400 5203494 5.03 178.7 µM 2.49E-7 RSC complex & mRNA processing 11 2.48E-7
10 SGTC_61 0978-8327 5.02 98.6 µM 2.59E-7 ergosterol biosynthesis 11 2.58E-7
11 SGTC_2964 9083345 4.99 53.4 µM 3.07E-7 8 3.06E-7
12 SGTC_2971 9092186 4.94 9.9 µM 3.96E-7 ergosterol biosynthesis 12 3.94E-7
13 SGTC_2963 9082507 4.84 9.0 µM 6.36E-7 12 6.33E-7
14 SGTC_899 1083-0020 4.74 478.0 µM 1.08E-6 10 1.08E-6
15 SGTC_3049 9092223 4.73 49.5 µM 1.13E-6 7 1.13E-6
16 SGTC_3164 9100705 4.70 49.5 µM 1.34E-6 2 1.33E-6
17 SGTC_1032 k061-1018 4.55 98.7 µM 2.70E-6 10 2.69E-6
18 SGTC_3127 9126946 4.48 49.5 µM 3.68E-6 ERG2 10 3.67E-6
19 SGTC_567 1080-0542 4.33 68.4 µM 7.36E-6 9 7.34E-6
20 SGTC_949 1165-0505 4.27 146.0 µM 9.76E-6 13 9.73E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.91E-13 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.091 1.45E-7 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.090 2.01E-7 YMR237W BCH1 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
0.088 3.67E-7 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.086 5.73E-7 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.086 6.29E-7 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.085 7.05E-7 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.079 5.34E-6 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.078 6.89E-6 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.076 9.81E-6 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.074 1.62E-5 YNL162W-A_p YNL162W-A_p hom Putative protein of unknown function; identified by homology
0.074 1.96E-5 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.071 3.56E-5 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.070 5.23E-5 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.070 5.37E-5 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon