YBL014C / RRN6

Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL014C / RRN6

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.04|P-value:8.73E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.24|P-value:4.00E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.36|P-value:1.67E-8 ID:SGTC_522|Compound:1273-0010|FD-Score:3.79|P-value:4.71E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.52|P-value:1.31E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.03|P-value:8.53E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.20|P-value:4.57E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.43|P-value:2.08E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.03|P-value:8.47E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:10.30|P-value:7.32E-27 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.74|P-value:5.91E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.99|P-value:9.75E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.29|P-value:3.52E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.03|P-value:9.00E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.13|P-value:6.00E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.33|P-value:3.02E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.28|P-value:3.62E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.68|P-value:2.32E-9 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.02|P-value:2.71E-10 ID:SGTC_2141|Compound:5621638|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-4.45|P-value:2.04E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.04|P-value:8.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.53|P-value:1.54E-6 ID:SGTC_2365|Compound:9042475|FD-Score:-4.77|P-value:4.07E-7 ID:SGTC_2427|Compound:5545055|FD-Score:4.02|P-value:1.71E-5 ID:SGTC_2431|Compound:5490079|FD-Score:6.65|P-value:3.36E-12 ID:SGTC_2432|Compound:5630864|FD-Score:3.46|P-value:1.85E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-4.56|P-value:1.16E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.55|P-value:1.28E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:9.21E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.07|P-value:1.36E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.64|P-value:8.20E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.15|P-value:5.94E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.13|P-value:6.25E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.17|P-value:5.51E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.08|P-value:1.32E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.21|P-value:4.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.77|P-value:4.71E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.19|P-value:4.68E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.04|P-value:8.73E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.24|P-value:4.00E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.36|P-value:1.67E-8 ID:SGTC_522|Compound:1273-0010|FD-Score:3.79|P-value:4.71E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.52|P-value:1.31E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.03|P-value:8.53E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.20|P-value:4.57E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.43|P-value:2.08E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.03|P-value:8.47E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:10.30|P-value:7.32E-27 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.74|P-value:5.91E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.99|P-value:9.75E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.29|P-value:3.52E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.03|P-value:9.00E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.13|P-value:6.00E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.33|P-value:3.02E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.28|P-value:3.62E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.68|P-value:2.32E-9 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.02|P-value:2.71E-10 ID:SGTC_2141|Compound:5621638|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-4.45|P-value:2.04E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.04|P-value:8.70E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.53|P-value:1.54E-6 ID:SGTC_2365|Compound:9042475|FD-Score:-4.77|P-value:4.07E-7 ID:SGTC_2427|Compound:5545055|FD-Score:4.02|P-value:1.71E-5 ID:SGTC_2431|Compound:5490079|FD-Score:6.65|P-value:3.36E-12 ID:SGTC_2432|Compound:5630864|FD-Score:3.46|P-value:1.85E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-4.56|P-value:1.16E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.55|P-value:1.28E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:9.21E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.07|P-value:1.36E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.64|P-value:8.20E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.15|P-value:5.94E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.13|P-value:6.25E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.17|P-value:5.51E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.08|P-value:1.32E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.21|P-value:4.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.77|P-value:4.71E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.19|P-value:4.68E-4

Top fitness defect scores for YBL014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1128 3448-9350 10.30 235.0 µM 7.32E-27 1 2.46E-25 3.37
2 SGTC_2431 5490079 6.65 200.0 µM 3.36E-12 1 1.43E-11 1.24
3 SGTC_2131 toluylene red 6.02 5.3 µM 2.71E-10 60S ribosome export 5 8.89E-10 0.02
4 SGTC_1726 st035556 5.68 14.6 µM 2.32E-9 2 6.68E-9 0.44
5 SGTC_184 1494-0393 5.36 24.7 µM 1.67E-8 13 4.27E-8 0.14
6 SGTC_2354 9060492 4.53 162.0 µM 1.54E-6 5 3.01E-6 0.50
7 SGTC_823 0417-1665 4.09 178.0 µM 1.23E-5 3 2.13E-5 0.28
8 SGTC_2955 9076254 4.08 12.2 µM 1.32E-5 4 2.28E-5 0.08
9 SGTC_2536 dehydroabietamide 4.07 32.0 µM 1.36E-5 6 2.34E-5 0.17
10 SGTC_2427 5545055 4.02 42.8 µM 1.71E-5 7 2.90E-5 0.07
11 SGTC_522 1273-0010 3.79 11.6 µM 4.71E-5 60S ribosome export 4 7.55E-5 0.06
12 SGTC_1190 1486-1332 3.74 13.0 µM 5.91E-5 6 9.35E-5 0.15
13 SGTC_2481 5478948 3.63 45.2 µM 9.21E-5 PDR1 10 1.42E-4 0.06
14 SGTC_40 0327-0103 3.61 19.8 µM 1.02E-4 7 1.56E-4 0.05
15 SGTC_2450 5739737 3.55 12.9 µM 1.28E-4 7 1.94E-4 0.01
16 SGTC_2171 5739187 3.53 198.1 µM 1.38E-4 copper-dependent oxidative stress 5 2.09E-4 0.01
17 SGTC_2922 7999257 3.48 32.5 µM 1.66E-4 10 2.48E-4 0.14
18 SGTC_2432 5630864 3.46 12.2 µM 1.85E-4 11 2.74E-4 0.07
19 SGTC_965 1291-5240 3.43 308.0 µM 2.08E-4 7 3.07E-4 0.06
20 SGTC_2246 7293507 3.41 91.6 µM 2.24E-4 17 3.29E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.28E-9 YGL006W PMC1 hom Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
0.098 1.09E-8 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.097 1.89E-8 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.095 4.22E-8 YER117W RPL23B hom Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication
0.092 1.01E-7 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.088 2.93E-7 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.087 4.05E-7 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
0.086 6.29E-7 YBL012C_d YBL012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 9.18E-7 YPL119C-A_p YPL119C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.085 9.31E-7 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.084 1.08E-6 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.083 1.39E-6 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.081 2.52E-6 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.080 3.41E-6 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.078 5.98E-6 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene