YBL018C / POP8

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL018C / POP8

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-5.31|P-value:4.42E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:3.82|P-value:1.60E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.12|P-value:3.38E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.78|P-value:1.99E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.08|P-value:4.38E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_493|Compound:zm226600|FD-Score:2.89|P-value:8.20E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.75|P-value:2.20E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.45|P-value:9.54E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.15|P-value:3.02E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.01|P-value:6.47E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.62|P-value:4.10E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.15|P-value:3.07E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:2.97|P-value:5.98E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.45|P-value:8.66E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.00|P-value:5.84E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.13|P-value:3.28E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.07|P-value:4.50E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-2.98|P-value:6.37E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.20|P-value:2.43E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-2.94|P-value:7.35E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.79|P-value:1.89E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.05|P-value:4.55E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.74|P-value:2.35E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-4.88|P-value:6.54E-8 ID:SGTC_1912|Compound:st060209|FD-Score:3.34|P-value:1.41E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.06|P-value:4.70E-4 ID:SGTC_1961|Compound:st076550|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.84|P-value:1.62E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.32|P-value:1.67E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.50|P-value:7.58E-5 ID:SGTC_2480|Compound:5767542|FD-Score:4.09|P-value:4.21E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.87|P-value:8.77E-4 ID:SGTC_2511|Compound:berberine|FD-Score:2.98|P-value:5.78E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.31|P-value:1.60E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.17|P-value:2.83E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.42|P-value:9.73E-5 ID:SGTC_2917|Compound:7979103|FD-Score:6.04|P-value:2.61E-11 ID:SGTC_2923|Compound:7992654|FD-Score:-3.37|P-value:1.33E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.40|P-value:2.22E-9 ID:SGTC_2972|Compound:9093619|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_2978|Compound:9011784|FD-Score:2.93|P-value:7.08E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.95|P-value:8.63E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.44|P-value:8.98E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-5.39|P-value:2.74E-9 ID:SGTC_3106|Compound:9121286|FD-Score:-3.58|P-value:5.52E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.10|P-value:3.73E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.23|P-value:2.42E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.47|P-value:8.69E-5 ID:SGTC_3328|Compound:9140624|FD-Score:5.22|P-value:6.95E-9 ID:SGTC_3335|Compound:9143315|FD-Score:-3.79|P-value:2.10E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.31|P-value:4.42E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:3.82|P-value:1.60E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.12|P-value:3.38E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.78|P-value:1.99E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.08|P-value:4.38E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_493|Compound:zm226600|FD-Score:2.89|P-value:8.20E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.75|P-value:2.20E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.45|P-value:9.54E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.15|P-value:3.02E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.01|P-value:6.47E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.62|P-value:4.10E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.15|P-value:3.07E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:2.97|P-value:5.98E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.45|P-value:8.66E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.00|P-value:5.84E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.13|P-value:3.28E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.07|P-value:4.50E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-2.98|P-value:6.37E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.20|P-value:2.43E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-2.94|P-value:7.35E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.79|P-value:1.89E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.05|P-value:4.55E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.74|P-value:2.35E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-4.88|P-value:6.54E-8 ID:SGTC_1912|Compound:st060209|FD-Score:3.34|P-value:1.41E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.06|P-value:4.70E-4 ID:SGTC_1961|Compound:st076550|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.84|P-value:1.62E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.32|P-value:1.67E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.50|P-value:7.58E-5 ID:SGTC_2480|Compound:5767542|FD-Score:4.09|P-value:4.21E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.87|P-value:8.77E-4 ID:SGTC_2511|Compound:berberine|FD-Score:2.98|P-value:5.78E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.31|P-value:1.60E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.17|P-value:2.83E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.42|P-value:9.73E-5 ID:SGTC_2917|Compound:7979103|FD-Score:6.04|P-value:2.61E-11 ID:SGTC_2923|Compound:7992654|FD-Score:-3.37|P-value:1.33E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.40|P-value:2.22E-9 ID:SGTC_2972|Compound:9093619|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_2978|Compound:9011784|FD-Score:2.93|P-value:7.08E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.95|P-value:8.63E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.44|P-value:8.98E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-5.39|P-value:2.74E-9 ID:SGTC_3106|Compound:9121286|FD-Score:-3.58|P-value:5.52E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.10|P-value:3.73E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.23|P-value:2.42E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.47|P-value:8.69E-5 ID:SGTC_3328|Compound:9140624|FD-Score:5.22|P-value:6.95E-9 ID:SGTC_3335|Compound:9143315|FD-Score:-3.79|P-value:2.10E-5

Top fitness defect scores for YBL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2917 7979103 6.04 53.8 µM 2.61E-11 2 7.71E-10 0.82
2 SGTC_2928 9011484 5.40 9.8 µM 2.22E-9 heme biosynthesis & mitochondrial translocase 18 3.40E-8 0.01
3 SGTC_3328 9140624 5.22 29.0 µM 6.95E-9 2 8.98E-8 1.39
4 SGTC_2480 5767542 4.09 37.2 µM 4.21E-6 4 2.12E-5 0.31
5 SGTC_794 k038-0031 4.01 316.0 µM 6.47E-6 ubiquinone biosynthesis & proteasome 20 3.05E-5 0.09
6 SGTC_3032 9089427 3.95 49.5 µM 8.63E-6 60S ribosome export 4 3.91E-5 0.00
7 SGTC_147 4466-0538 3.82 29.2 µM 1.60E-5 ergosterol biosynthesis 10 6.62E-5 0.07
8 SGTC_1297 1068-0111 3.79 14.1 µM 1.89E-5 6 7.63E-5 0.38
9 SGTC_341 1486-1430 3.78 230.0 µM 1.99E-5 25 7.98E-5 0.02
10 SGTC_633 0437-0093 3.75 97.7 µM 2.20E-5 DNA intercalators 12 8.67E-5 0.09
11 SGTC_1688 st021091 3.74 57.6 µM 2.35E-5 3 9.21E-5 0.12
12 SGTC_812 4251-0442 3.62 148.0 µM 4.10E-5 5 1.48E-4 0.02
13 SGTC_1011 4112-3381 3.45 17.4 µM 8.66E-5 4 2.80E-4 0.12
14 SGTC_3048 9093155 3.44 49.5 µM 8.98E-5 2 2.89E-4 0.04
15 SGTC_2811 7967822 3.42 32.5 µM 9.73E-5 10 3.10E-4 0.04
16 SGTC_762 1165-0429 3.36 115.0 µM 1.29E-4 TSC3-RPN4 7 3.93E-4 0.10
17 SGTC_1912 st060209 3.34 90.8 µM 1.41E-4 20 4.25E-4 0.02
18 SGTC_2563 tomatine 3.31 8.5 µM 1.60E-4 19 4.73E-4 0.03
19 SGTC_353 1988-1175 3.24 58.3 µM 2.11E-4 unfolded protein response 20 6.01E-4 0.07
20 SGTC_1152 3909-8331 3.20 15.9 µM 2.43E-4 10 6.79E-4 0.27

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.18E-15 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.128 1.20E-13 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.107 5.98E-10 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.100 5.78E-9 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.100 7.81E-9 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.098 1.49E-8 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.097 2.01E-8 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.096 2.29E-8 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.096 2.79E-8 YDR344C_d YDR344C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 6.46E-8 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.093 7.75E-8 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.092 8.67E-8 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.091 1.47E-7 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.090 1.75E-7 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.090 1.91E-7 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease