YBL022C / PIM1

ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL022C / PIM1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.48|P-value:5.26E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:2.43E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.68|P-value:5.14E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.75|P-value:4.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.75|P-value:4.08E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.72|P-value:6.66E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.14|P-value:1.71E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.17|P-value:1.57E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.71|P-value:2.30E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.16|P-value:3.89E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.60|P-value:3.34E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.80|P-value:1.27E-33 ID:SGTC_535|Compound:2293-4129|FD-Score:7.28|P-value:1.19E-10 ID:SGTC_568|Compound:1193-0097|FD-Score:7.59|P-value:2.04E-11 ID:SGTC_582|Compound:0987-0078|FD-Score:4.01|P-value:2.67E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.40|P-value:7.06E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:7.42|P-value:5.34E-11 ID:SGTC_690|Compound:glyoxal|FD-Score:6.13|P-value:5.04E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.96|P-value:3.10E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.55|P-value:4.17E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.55|P-value:7.26E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.76|P-value:5.85E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.09|P-value:1.34E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.72|P-value:6.64E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.54|P-value:7.90E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.89|P-value:3.89E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.73|P-value:6.48E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-4.20|P-value:9.10E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.37|P-value:7.79E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.50|P-value:8.78E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.95|P-value:8.95E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.64|P-value:8.56E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.44|P-value:6.05E-5 ID:SGTC_1712|Compound:st032288|FD-Score:10.20|P-value:2.78E-19 ID:SGTC_1754|Compound:st042065|FD-Score:8.31|P-value:2.38E-13 ID:SGTC_1760|Compound:st045453|FD-Score:5.80|P-value:2.43E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.89|P-value:2.01E-15 ID:SGTC_1797|Compound:st048695|FD-Score:5.38|P-value:1.54E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:6.43E-4 ID:SGTC_1801|Compound:st050089|FD-Score:8.88|P-value:5.04E-15 ID:SGTC_1803|Compound:st050068|FD-Score:5.67|P-value:4.23E-7 ID:SGTC_1856|Compound:st057054|FD-Score:5.32|P-value:1.96E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.67|P-value:7.68E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.61|P-value:9.34E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.62|P-value:9.06E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.86|P-value:1.27E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.36|P-value:1.66E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.59|P-value:9.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.24|P-value:1.24E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.04|P-value:1.59E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.66|P-value:8.08E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-5.92|P-value:7.58E-8 ID:SGTC_2308|Compound:7584454|FD-Score:-10.30|P-value:7.18E-20 ID:SGTC_2318|Compound:6029776|FD-Score:-4.31|P-value:6.23E-5 ID:SGTC_2335|Compound:9018011|FD-Score:-3.54|P-value:8.01E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.46|P-value:5.72E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.53|P-value:8.04E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.16|P-value:3.91E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.60|P-value:2.72E-24 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.98|P-value:1.02E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.89|P-value:3.92E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.59|P-value:9.68E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.47|P-value:5.41E-5 ID:SGTC_2902|Compound:5787006|FD-Score:4.79|P-value:1.67E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-5.24|P-value:1.65E-6 ID:SGTC_2916|Compound:7875993|FD-Score:4.36|P-value:8.18E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.77|P-value:3.85E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.90|P-value:2.55E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.59|P-value:9.86E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.81|P-value:5.26E-12 ID:SGTC_3152|Compound:9099253|FD-Score:6.45|P-value:1.06E-8 ID:SGTC_3266|Compound:9136860|FD-Score:5.08|P-value:5.33E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.10|P-value:4.87E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.90|P-value:3.83E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.70|P-value:3.70E-7 ID:SGTC_3356|Compound:9151811|FD-Score:4.30|P-value:9.91E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.48|P-value:5.26E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:2.43E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.68|P-value:5.14E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.75|P-value:4.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.75|P-value:4.08E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.72|P-value:6.66E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.14|P-value:1.71E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.17|P-value:1.57E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.71|P-value:2.30E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.16|P-value:3.89E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.60|P-value:3.34E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.80|P-value:1.27E-33 ID:SGTC_535|Compound:2293-4129|FD-Score:7.28|P-value:1.19E-10 ID:SGTC_568|Compound:1193-0097|FD-Score:7.59|P-value:2.04E-11 ID:SGTC_582|Compound:0987-0078|FD-Score:4.01|P-value:2.67E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.40|P-value:7.06E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:7.42|P-value:5.34E-11 ID:SGTC_690|Compound:glyoxal|FD-Score:6.13|P-value:5.04E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.96|P-value:3.10E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.55|P-value:4.17E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.55|P-value:7.26E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.76|P-value:5.85E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.09|P-value:1.34E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.94|P-value:3.29E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.72|P-value:6.64E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.54|P-value:7.90E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.89|P-value:3.89E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.73|P-value:6.48E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-4.20|P-value:9.10E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.37|P-value:7.79E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.50|P-value:8.78E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.95|P-value:8.95E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.64|P-value:8.56E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.44|P-value:6.05E-5 ID:SGTC_1712|Compound:st032288|FD-Score:10.20|P-value:2.78E-19 ID:SGTC_1754|Compound:st042065|FD-Score:8.31|P-value:2.38E-13 ID:SGTC_1760|Compound:st045453|FD-Score:5.80|P-value:2.43E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.89|P-value:2.01E-15 ID:SGTC_1797|Compound:st048695|FD-Score:5.38|P-value:1.54E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:6.43E-4 ID:SGTC_1801|Compound:st050089|FD-Score:8.88|P-value:5.04E-15 ID:SGTC_1803|Compound:st050068|FD-Score:5.67|P-value:4.23E-7 ID:SGTC_1856|Compound:st057054|FD-Score:5.32|P-value:1.96E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.67|P-value:7.68E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.61|P-value:9.34E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.62|P-value:9.06E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.86|P-value:1.27E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.36|P-value:1.66E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.59|P-value:9.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.24|P-value:1.24E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.04|P-value:1.59E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.66|P-value:8.08E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-5.92|P-value:7.58E-8 ID:SGTC_2308|Compound:7584454|FD-Score:-10.30|P-value:7.18E-20 ID:SGTC_2318|Compound:6029776|FD-Score:-4.31|P-value:6.23E-5 ID:SGTC_2335|Compound:9018011|FD-Score:-3.54|P-value:8.01E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.46|P-value:5.72E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.53|P-value:8.04E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.16|P-value:3.91E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.60|P-value:2.72E-24 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.98|P-value:1.02E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.89|P-value:3.92E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.59|P-value:9.68E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.47|P-value:5.41E-5 ID:SGTC_2902|Compound:5787006|FD-Score:4.79|P-value:1.67E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-5.24|P-value:1.65E-6 ID:SGTC_2916|Compound:7875993|FD-Score:4.36|P-value:8.18E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.77|P-value:3.85E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.90|P-value:2.55E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.59|P-value:9.86E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.81|P-value:5.26E-12 ID:SGTC_3152|Compound:9099253|FD-Score:6.45|P-value:1.06E-8 ID:SGTC_3266|Compound:9136860|FD-Score:5.08|P-value:5.33E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.10|P-value:4.87E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.90|P-value:3.83E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.70|P-value:3.70E-7 ID:SGTC_3356|Compound:9151811|FD-Score:4.30|P-value:9.91E-5

Top fitness defect scores for YBL022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 13.80 172.0 µM 1.27E-33 calcium & mitochondrial duress 20 1.90E-43
2 SGTC_2688 kanamycin b 11.60 96.7 µM 2.72E-24 calcium & mitochondrial duress 15 2.73E-31
3 SGTC_1712 st032288 10.20 53.4 µM 2.78E-19 calcium & mitochondrial duress 23 9.26E-25
4 SGTC_1801 st050089 8.88 28.4 µM 5.04E-15 NEO1-PIK1 19 3.28E-19
5 SGTC_1754 st042065 8.31 16.1 µM 2.38E-13 NEO1-PIK1 52 4.98E-17
6 SGTC_3037 9091026 7.81 49.5 µM 5.26E-12 NEO1-PIK1 19 2.82E-15
7 SGTC_568 1193-0097 7.59 7.5 µM 2.04E-11 ERAD & cell cycle 39 1.65E-14
8 SGTC_637 1181-0519 7.42 7.3 µM 5.34E-11 fatty acid desaturase (OLE1) 35 5.78E-14
9 SGTC_535 2293-4129 7.28 48.2 µM 1.19E-10 NEO1 16 1.64E-13
10 SGTC_3152 9099253 6.45 49.5 µM 1.06E-8 NEO1-PIK1 48 5.68E-11
11 SGTC_690 glyoxal 6.13 20.3 µM 5.04E-8 41 4.35E-10
12 SGTC_2697 mebhydrolin 5.98 72.4 µM 1.02E-7 NEO1 29 1.10E-9
13 SGTC_1760 st045453 5.80 10.4 µM 2.43E-7 NEO1-PIK1 85 3.38E-9
14 SGTC_3351 9150312 5.70 21.6 µM 3.70E-7 cell wall 11 5.83E-9
15 SGTC_1803 st050068 5.67 52.4 µM 4.23E-7 NEO1-PIK1 92 6.96E-9
16 SGTC_863 0466-0191 5.55 129.0 µM 7.26E-7 cell wall 34 1.40E-8
17 SGTC_1797 st048695 5.38 56.8 µM 1.54E-6 NEO1 50 3.72E-8
18 SGTC_2006 4011487 5.36 200.0 µM 1.66E-6 endomembrane recycling 53 4.13E-8
19 SGTC_1856 st057054 5.32 55.7 µM 1.96E-6 10 5.11E-8
20 SGTC_363 0455-0021 5.16 3.1 µM 3.89E-6 azole & statin 39 1.25E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 6.03E-111 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.370 2.36E-109 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.364 1.37E-105 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.363 7.16E-105 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.355 5.13E-100 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.340 1.29E-91 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.337 1.08E-89 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.335 2.98E-88 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.323 4.24E-82 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.319 3.53E-80 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.308 8.74E-75 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.306 1.21E-73 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.299 2.98E-70 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.299 3.71E-70 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.295 1.69E-68 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern