HIPHOP chemogenomics database
YBL023C / MCM2 
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YBL023C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.113 | 4.78E-11 | YDR023W | SES1 | het | Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p |
| 0.109 | 2.61E-10 | YBL004W | UTP20 | het | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
| 0.108 | 3.24E-10 | YNL161W | CBK1 | het | Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress |
| 0.108 | 3.52E-10 | YLR212C | TUB4 | het | Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress |
| 0.105 | 1.08E-9 | YNL163C | RIA1 | het | Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes |
| 0.105 | 1.12E-9 | YPR103W | PRE2 | het | Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
| 0.100 | 7.42E-9 | YDR235W | PRP42 | het | U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats |
| 0.096 | 3.04E-8 | YMR218C | TRS130 | het | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy |
| 0.092 | 8.81E-8 | YER127W | LCP5 | het | Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus |
| 0.091 | 1.14E-7 | YDL208W | NHP2 | het | Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing |
| 0.089 | 2.55E-7 | YBR053C_p | YBR053C_p | hom | Putative protein of unknown function; induced by cell wall perturbation |
| 0.088 | 3.76E-7 | YER171W | RAD3 | het | 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress |
| 0.086 | 6.98E-7 | YML115C | VAN1 | hom | Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant |
| 0.085 | 7.87E-7 | YER038C | KRE29 | het | Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
| 0.085 | 8.46E-7 | YDR177W | UBC1 | het | Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress |