YBL023C / MCM2

Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL023C / MCM2

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.50|P-value:4.67E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.99|P-value:1.14E-11 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.48|P-value:5.14E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.46|P-value:2.94E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.85|P-value:8.68E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:5.45|P-value:4.09E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.45|P-value:3.10E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.47|P-value:2.81E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.02|P-value:3.47E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.56|P-value:3.32E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.52|P-value:8.88E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:4.44|P-value:5.83E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.44|P-value:3.20E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.56|P-value:3.82E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.76|P-value:9.76E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.94|P-value:9.54E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.45|P-value:3.04E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.48|P-value:4.88E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.93|P-value:4.91E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.67|P-value:1.34E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.54|P-value:3.65E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.63|P-value:1.56E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.40|P-value:3.70E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.28|P-value:5.57E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.75|P-value:1.96E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.68|P-value:1.32E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.91|P-value:1.95E-11 ID:SGTC_2116|Compound:5511452|FD-Score:4.91|P-value:6.48E-7 ID:SGTC_2120|Compound:5538279|FD-Score:5.43|P-value:4.55E-8 ID:SGTC_2177|Compound:5811945|FD-Score:-3.30|P-value:9.25E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.28|P-value:2.46E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.57|P-value:3.66E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.76|P-value:9.77E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.20|P-value:7.17E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.19|P-value:3.58E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.85|P-value:1.34E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.94|P-value:4.82E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.62|P-value:2.61E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.40|P-value:6.71E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:6.81E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-5.75|P-value:2.01E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.36|P-value:4.22E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.40|P-value:6.77E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.80|P-value:2.53E-6 ID:SGTC_2700|Compound:st077718|FD-Score:3.14|P-value:8.69E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.45|P-value:3.06E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:6.15|P-value:7.48E-10 ID:SGTC_2849|Compound:9019321|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.32|P-value:8.82E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_2983|Compound:9022671|FD-Score:4.68|P-value:1.94E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.19|P-value:7.49E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.77|P-value:1.83E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.66|P-value:4.74E-6 ID:SGTC_3077|Compound:9117319|FD-Score:3.73|P-value:1.09E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.59|P-value:3.44E-4 ID:SGTC_3102|Compound:9121669|FD-Score:5.13|P-value:2.17E-7 ID:SGTC_3110|Compound:9122132|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_3157|Compound:9099274|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_3169|Compound:9102970|FD-Score:3.49|P-value:2.63E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.34|P-value:4.50E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.19|P-value:7.53E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.32|P-value:4.76E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.50|P-value:4.67E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.99|P-value:1.14E-11 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.48|P-value:5.14E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.46|P-value:2.94E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.85|P-value:8.68E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:5.45|P-value:4.09E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.45|P-value:3.10E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.47|P-value:2.81E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.02|P-value:3.47E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.56|P-value:3.32E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.52|P-value:8.88E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:4.44|P-value:5.83E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.44|P-value:3.20E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.56|P-value:3.82E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.76|P-value:9.76E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.94|P-value:9.54E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.45|P-value:3.04E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.48|P-value:4.88E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.93|P-value:4.91E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.67|P-value:1.34E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.54|P-value:3.65E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.63|P-value:1.56E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.40|P-value:3.70E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.28|P-value:5.57E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.75|P-value:1.96E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.68|P-value:1.32E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.91|P-value:1.95E-11 ID:SGTC_2116|Compound:5511452|FD-Score:4.91|P-value:6.48E-7 ID:SGTC_2120|Compound:5538279|FD-Score:5.43|P-value:4.55E-8 ID:SGTC_2177|Compound:5811945|FD-Score:-3.30|P-value:9.25E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.28|P-value:2.46E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.57|P-value:3.66E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.76|P-value:9.77E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.20|P-value:7.17E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.19|P-value:3.58E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.85|P-value:1.34E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.94|P-value:4.82E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.62|P-value:2.61E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.40|P-value:6.71E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:6.81E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-5.75|P-value:2.01E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:3.36|P-value:4.22E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.40|P-value:6.77E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.80|P-value:2.53E-6 ID:SGTC_2700|Compound:st077718|FD-Score:3.14|P-value:8.69E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.45|P-value:3.06E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:6.15|P-value:7.48E-10 ID:SGTC_2849|Compound:9019321|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.32|P-value:8.82E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_2983|Compound:9022671|FD-Score:4.68|P-value:1.94E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.19|P-value:7.49E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.77|P-value:1.83E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.66|P-value:4.74E-6 ID:SGTC_3077|Compound:9117319|FD-Score:3.73|P-value:1.09E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.59|P-value:3.44E-4 ID:SGTC_3102|Compound:9121669|FD-Score:5.13|P-value:2.17E-7 ID:SGTC_3110|Compound:9122132|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_3157|Compound:9099274|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_3169|Compound:9102970|FD-Score:3.49|P-value:2.63E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.34|P-value:4.50E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.19|P-value:7.53E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.32|P-value:4.76E-4

Top fitness defect scores for YBL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2821 7996764 6.15 71.4 µM 7.48E-10 3 3.84E-10 1.12
2 SGTC_533 1222-0222 5.45 6.7 µM 4.09E-8 PDR1 3 2.54E-8 0.37
3 SGTC_2120 5538279 5.43 152.0 µM 4.55E-8 2 2.85E-8 1.15
4 SGTC_3102 9121669 5.13 49.5 µM 2.17E-7 2 1.46E-7 0.93
5 SGTC_2116 5511452 4.91 16.9 µM 6.48E-7 1 4.59E-7 0.65
6 SGTC_429 1112-0049 4.85 25.5 µM 8.68E-7 DNA damage response 5 6.23E-7 0.48
7 SGTC_3157 9099274 4.70 49.5 µM 1.73E-6 2 1.28E-6 0.60
8 SGTC_2983 9022671 4.68 13.0 µM 1.94E-6 60S ribosome export 7 1.44E-6 0.36
9 SGTC_2502 avocadyne acetate 4.62 18.6 µM 2.61E-6 5 1.97E-6 0.30
10 SGTC_668 1682-0499 4.56 62.6 µM 3.32E-6 3 2.53E-6 0.61
11 SGTC_1272 0839-0021 4.54 27.0 µM 3.65E-6 1 2.80E-6 0.26
12 SGTC_977 1348-1378 4.48 135.0 µM 4.88E-6 5 3.79E-6 0.21
13 SGTC_787 4152-0075 4.44 138.0 µM 5.83E-6 3 4.55E-6 0.45
14 SGTC_2614 arthonioic acid 4.40 13.4 µM 6.77E-6 1 5.33E-6 0.44
15 SGTC_905 2-aminofluorene 4.30 215.0 µM 1.05E-5 cell wall signaling 3 8.42E-6 0.13
16 SGTC_879 0831-1030 4.17 162.0 µM 1.89E-5 20 1.56E-5 0.19
17 SGTC_3110 9122132 4.15 49.5 µM 2.02E-5 redox potentiating 7 1.66E-5 0.25
18 SGTC_3266 9136860 4.08 49.5 µM 2.69E-5 cell wall 12 2.24E-5 0.19
19 SGTC_655 k060-0012 4.02 42.0 µM 3.47E-5 4 2.92E-5 0.06
20 SGTC_2496 diffractaic acid 3.94 79.8 µM 4.82E-5 6 4.12E-5 0.30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.78E-11 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.109 2.61E-10 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.108 3.24E-10 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.108 3.52E-10 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.105 1.08E-9 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.105 1.12E-9 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.100 7.42E-9 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.096 3.04E-8 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.092 8.81E-8 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.091 1.14E-7 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.089 2.55E-7 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.088 3.76E-7 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.086 6.98E-7 YML115C VAN1 hom Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.085 7.87E-7 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.085 8.46E-7 YDR177W UBC1 het Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress