YBL026W / LSM2

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL026W / LSM2

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:6.61|P-value:7.05E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:6.94|P-value:1.58E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.14|P-value:4.74E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:13.80|P-value:1.31E-28 ID:SGTC_227|Compound:fluconazole|FD-Score:5.06|P-value:2.82E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:7.73|P-value:3.73E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:7.27|P-value:3.46E-9 ID:SGTC_332|Compound:4112-0506|FD-Score:4.69|P-value:9.22E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.91|P-value:9.01E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.78|P-value:2.06E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:10.70|P-value:8.40E-18 ID:SGTC_393|Compound:acivicin|FD-Score:-5.14|P-value:2.09E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:4.47|P-value:1.83E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.59|P-value:7.34E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:6.07|P-value:6.64E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.83|P-value:5.97E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:5.76|P-value:2.22E-6 ID:SGTC_584|Compound:0986-0246|FD-Score:4.11|P-value:5.37E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.10|P-value:5.39E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.95|P-value:8.29E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:6.27|P-value:2.89E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:6.75|P-value:3.75E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.89|P-value:4.86E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:4.88|P-value:5.02E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.60|P-value:1.26E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.29|P-value:3.13E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.48|P-value:1.78E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:3.23E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.16|P-value:1.99E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:6.80|P-value:3.07E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:3.95|P-value:8.20E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.15|P-value:4.61E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.31|P-value:2.99E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:6.42|P-value:1.59E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.76|P-value:7.46E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.07|P-value:5.99E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:9.24|P-value:8.92E-14 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.18|P-value:5.22E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.86|P-value:5.31E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.54|P-value:1.47E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.95|P-value:8.28E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.27|P-value:3.33E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.07|P-value:5.86E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.48|P-value:1.77E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.20|P-value:4.13E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.93|P-value:8.84E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.46|P-value:6.84E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:12.30|P-value:4.09E-23 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.94|P-value:8.39E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.31|P-value:1.16E-5 ID:SGTC_1616|Compound:st002734|FD-Score:5.21|P-value:1.63E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.97|P-value:7.75E-4 ID:SGTC_1652|Compound:st011932|FD-Score:12.00|P-value:5.09E-22 ID:SGTC_1707|Compound:st032323|FD-Score:11.40|P-value:5.82E-20 ID:SGTC_1723|Compound:st034307|FD-Score:5.90|P-value:1.31E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.33|P-value:1.08E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.65|P-value:1.04E-4 ID:SGTC_1740|Compound:st038286|FD-Score:7.15|P-value:6.07E-9 ID:SGTC_1745|Compound:st081495|FD-Score:17.20|P-value:3.53E-43 ID:SGTC_1750|Compound:st081859|FD-Score:5.07|P-value:2.73E-5 ID:SGTC_1754|Compound:st042065|FD-Score:8.23|P-value:2.70E-11 ID:SGTC_1761|Compound:st044296|FD-Score:4.10|P-value:5.46E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.02|P-value:3.17E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.46|P-value:1.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:6.61|P-value:7.05E-8 ID:SGTC_1871|Compound:st057448|FD-Score:5.17|P-value:1.90E-5 ID:SGTC_1884|Compound:5633444|FD-Score:7.35|P-value:2.40E-9 ID:SGTC_1915|Compound:st067105|FD-Score:9.78|P-value:3.17E-15 ID:SGTC_1959|Compound:st077091|FD-Score:7.12|P-value:6.94E-9 ID:SGTC_2016|Compound:5121758|FD-Score:4.08|P-value:5.84E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.89|P-value:9.64E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-5.08|P-value:2.54E-5 ID:SGTC_2041|Compound:5107442|FD-Score:13.20|P-value:4.13E-26 ID:SGTC_2066|Compound:5222451|FD-Score:-6.01|P-value:8.22E-7 ID:SGTC_2109|Compound:5483026|FD-Score:7.05|P-value:9.83E-9 ID:SGTC_2111|Compound:5486399|FD-Score:5.13|P-value:2.15E-5 ID:SGTC_2140|Compound:5586273|FD-Score:6.71|P-value:4.46E-8 ID:SGTC_2187|Compound:6125751|FD-Score:4.17|P-value:4.44E-4 ID:SGTC_2192|Compound:5915882|FD-Score:12.10|P-value:2.10E-22 ID:SGTC_2229|Compound:7354935|FD-Score:7.22|P-value:4.38E-9 ID:SGTC_2275|Compound:7947463|FD-Score:5.35|P-value:1.02E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.91|P-value:9.11E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.14|P-value:4.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:6.59|P-value:7.68E-8 ID:SGTC_2378|Compound:9074213|FD-Score:6.07|P-value:6.75E-7 ID:SGTC_2389|Compound:9091542|FD-Score:4.45|P-value:1.94E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.17|P-value:1.92E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.32|P-value:2.88E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.38|P-value:1.83E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.26|P-value:3.44E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.18|P-value:4.25E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.34|P-value:2.71E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.59|P-value:4.21E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.37|P-value:2.53E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.53|P-value:1.55E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.99|P-value:3.49E-5 ID:SGTC_2912|Compound:7964298|FD-Score:11.90|P-value:1.21E-21 ID:SGTC_2917|Compound:7979103|FD-Score:-4.55|P-value:1.43E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.21|P-value:3.65E-7 ID:SGTC_2928|Compound:9011484|FD-Score:-5.12|P-value:2.22E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-6.50|P-value:1.11E-7 ID:SGTC_2997|Compound:9067075|FD-Score:5.51|P-value:5.70E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.06|P-value:6.04E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.37|P-value:9.30E-6 ID:SGTC_3065|Compound:9113888|FD-Score:5.95|P-value:1.07E-6 ID:SGTC_3081|Compound:9117243|FD-Score:-4.28|P-value:3.19E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.31|P-value:3.03E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.89|P-value:9.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-9.68|P-value:5.77E-15 ID:SGTC_3140|Compound:9094243|FD-Score:4.00|P-value:7.18E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.15|P-value:4.66E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.30|P-value:1.20E-5 ID:SGTC_3236|Compound:9132701|FD-Score:5.26|P-value:1.38E-5 ID:SGTC_3247|Compound:9135149|FD-Score:8.55|P-value:4.74E-12 ID:SGTC_3341|Compound:9147222|FD-Score:4.56|P-value:1.42E-4 ID:SGTC_3347|Compound:9188721|FD-Score:16.90|P-value:1.47E-41 ID:SGTC_22|Compound:0964-0034|FD-Score:6.61|P-value:7.05E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:6.94|P-value:1.58E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.14|P-value:4.74E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:13.80|P-value:1.31E-28 ID:SGTC_227|Compound:fluconazole|FD-Score:5.06|P-value:2.82E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:7.73|P-value:3.73E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:7.27|P-value:3.46E-9 ID:SGTC_332|Compound:4112-0506|FD-Score:4.69|P-value:9.22E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.91|P-value:9.01E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.78|P-value:2.06E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:10.70|P-value:8.40E-18 ID:SGTC_393|Compound:acivicin|FD-Score:-5.14|P-value:2.09E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:4.47|P-value:1.83E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.59|P-value:7.34E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:6.07|P-value:6.64E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.83|P-value:5.97E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:5.76|P-value:2.22E-6 ID:SGTC_584|Compound:0986-0246|FD-Score:4.11|P-value:5.37E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.10|P-value:5.39E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.95|P-value:8.29E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:6.27|P-value:2.89E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:6.75|P-value:3.75E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:4.89|P-value:4.86E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:4.88|P-value:5.02E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.60|P-value:1.26E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.29|P-value:3.13E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.48|P-value:1.78E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:3.23E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.16|P-value:1.99E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:6.80|P-value:3.07E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:3.95|P-value:8.20E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.15|P-value:4.61E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.31|P-value:2.99E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:6.42|P-value:1.59E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.76|P-value:7.46E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.07|P-value:5.99E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:9.24|P-value:8.92E-14 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.18|P-value:5.22E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.86|P-value:5.31E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.54|P-value:1.47E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.95|P-value:8.28E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.27|P-value:3.33E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.07|P-value:5.86E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.48|P-value:1.77E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.20|P-value:4.13E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.93|P-value:8.84E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.46|P-value:6.84E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:12.30|P-value:4.09E-23 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.94|P-value:8.39E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.31|P-value:1.16E-5 ID:SGTC_1616|Compound:st002734|FD-Score:5.21|P-value:1.63E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.97|P-value:7.75E-4 ID:SGTC_1652|Compound:st011932|FD-Score:12.00|P-value:5.09E-22 ID:SGTC_1707|Compound:st032323|FD-Score:11.40|P-value:5.82E-20 ID:SGTC_1723|Compound:st034307|FD-Score:5.90|P-value:1.31E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.33|P-value:1.08E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.65|P-value:1.04E-4 ID:SGTC_1740|Compound:st038286|FD-Score:7.15|P-value:6.07E-9 ID:SGTC_1745|Compound:st081495|FD-Score:17.20|P-value:3.53E-43 ID:SGTC_1750|Compound:st081859|FD-Score:5.07|P-value:2.73E-5 ID:SGTC_1754|Compound:st042065|FD-Score:8.23|P-value:2.70E-11 ID:SGTC_1761|Compound:st044296|FD-Score:4.10|P-value:5.46E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.02|P-value:3.17E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.46|P-value:1.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:6.61|P-value:7.05E-8 ID:SGTC_1871|Compound:st057448|FD-Score:5.17|P-value:1.90E-5 ID:SGTC_1884|Compound:5633444|FD-Score:7.35|P-value:2.40E-9 ID:SGTC_1915|Compound:st067105|FD-Score:9.78|P-value:3.17E-15 ID:SGTC_1959|Compound:st077091|FD-Score:7.12|P-value:6.94E-9 ID:SGTC_2016|Compound:5121758|FD-Score:4.08|P-value:5.84E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.89|P-value:9.64E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-5.08|P-value:2.54E-5 ID:SGTC_2041|Compound:5107442|FD-Score:13.20|P-value:4.13E-26 ID:SGTC_2066|Compound:5222451|FD-Score:-6.01|P-value:8.22E-7 ID:SGTC_2109|Compound:5483026|FD-Score:7.05|P-value:9.83E-9 ID:SGTC_2111|Compound:5486399|FD-Score:5.13|P-value:2.15E-5 ID:SGTC_2140|Compound:5586273|FD-Score:6.71|P-value:4.46E-8 ID:SGTC_2187|Compound:6125751|FD-Score:4.17|P-value:4.44E-4 ID:SGTC_2192|Compound:5915882|FD-Score:12.10|P-value:2.10E-22 ID:SGTC_2229|Compound:7354935|FD-Score:7.22|P-value:4.38E-9 ID:SGTC_2275|Compound:7947463|FD-Score:5.35|P-value:1.02E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.91|P-value:9.11E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.14|P-value:4.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:6.59|P-value:7.68E-8 ID:SGTC_2378|Compound:9074213|FD-Score:6.07|P-value:6.75E-7 ID:SGTC_2389|Compound:9091542|FD-Score:4.45|P-value:1.94E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.17|P-value:1.92E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.32|P-value:2.88E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.38|P-value:1.83E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.26|P-value:3.44E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.18|P-value:4.25E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.34|P-value:2.71E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.59|P-value:4.21E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.37|P-value:2.53E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.53|P-value:1.55E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.99|P-value:3.49E-5 ID:SGTC_2912|Compound:7964298|FD-Score:11.90|P-value:1.21E-21 ID:SGTC_2917|Compound:7979103|FD-Score:-4.55|P-value:1.43E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.21|P-value:3.65E-7 ID:SGTC_2928|Compound:9011484|FD-Score:-5.12|P-value:2.22E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-6.50|P-value:1.11E-7 ID:SGTC_2997|Compound:9067075|FD-Score:5.51|P-value:5.70E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.06|P-value:6.04E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.37|P-value:9.30E-6 ID:SGTC_3065|Compound:9113888|FD-Score:5.95|P-value:1.07E-6 ID:SGTC_3081|Compound:9117243|FD-Score:-4.28|P-value:3.19E-4 ID:SGTC_3112|Compound:9123419|FD-Score:4.31|P-value:3.03E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.89|P-value:9.49E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-9.68|P-value:5.77E-15 ID:SGTC_3140|Compound:9094243|FD-Score:4.00|P-value:7.18E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.15|P-value:4.66E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.30|P-value:1.20E-5 ID:SGTC_3236|Compound:9132701|FD-Score:5.26|P-value:1.38E-5 ID:SGTC_3247|Compound:9135149|FD-Score:8.55|P-value:4.74E-12 ID:SGTC_3341|Compound:9147222|FD-Score:4.56|P-value:1.42E-4 ID:SGTC_3347|Compound:9188721|FD-Score:16.90|P-value:1.47E-41

Top fitness defect scores for YBL026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1745 st081495 17.20 74.0 µM 3.53E-43 RNA processing & uracil transport 1 8.90E-67 7.05
2 SGTC_3347 9188721 16.90 44.7 µM 1.47E-41 2 3.10E-64 5.76
3 SGTC_138 0850-0259 13.80 40.9 µM 1.31E-28 cell wall 8 6.76E-44 1.97
4 SGTC_2041 5107442 13.20 45.3 µM 4.13E-26 RSC complex & mRNA processing 3 5.65E-40 1.87
5 SGTC_1374 2889-5571 12.30 141.0 µM 4.09E-23 RSC complex & mRNA processing 8 2.83E-35 0.26
6 SGTC_2192 5915882 12.10 198.5 µM 2.10E-22 RNA processing & uracil transport 1 3.68E-34 3.15
7 SGTC_1652 st011932 12.00 78.0 µM 5.09E-22 RSC complex & mRNA processing 9 1.48E-33 0.90
8 SGTC_2912 7964298 11.90 10.9 µM 1.21E-21 cell wall 9 5.73E-33 0.27
9 SGTC_1707 st032323 11.40 6.3 µM 5.82E-20 DNA damage response 3 2.49E-30 0.17
10 SGTC_354 2783-3500 10.70 4.9 µM 8.40E-18 cell wall 2 6.04E-27 1.33
11 SGTC_1915 st067105 9.78 30.6 µM 3.17E-15 RNA pol III & RNase P/MRP 7 6.56E-23 0.24
12 SGTC_1124 fisetin 9.24 1.2 µM 8.92E-14 1 1.21E-20 1.67
13 SGTC_3247 9135149 8.55 49.5 µM 4.74E-12 DNA damage response 4 6.06E-18 0.07
14 SGTC_1754 st042065 8.23 16.1 µM 2.70E-11 NEO1-PIK1 7 9.18E-17 0.65
15 SGTC_248 streptozotocin 7.73 5.2 mM 3.73E-10 DNA damage response 5 5.54E-15 0.76
16 SGTC_445 e6 berbamine 7.59 66.0 µM 7.34E-10 NEO1-PIK1 7 1.59E-14 0.36
17 SGTC_1884 5633444 7.35 25.0 µM 2.40E-9 redox potentiating 4 1.01E-13 0.91
18 SGTC_268 camptothecin 7.27 39.6 µM 3.46E-9 DNA damage response 15 1.79E-13 0.07
19 SGTC_2229 7354935 7.22 190.0 µM 4.38E-9 RSC complex & mRNA processing 6 2.59E-13 0.17
20 SGTC_1133 3473-0247 7.18 50.0 µM 5.22E-9 RSC complex & mRNA processing 15 3.41E-13 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.594 2.59E-319 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.558 2.76E-274 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.553 8.20E-268 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.451 3.98E-168 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.438 1.66E-156 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.356 7.38E-101 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.333 1.77E-87 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.305 2.16E-73 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.299 3.47E-70 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.298 1.16E-69 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.293 3.17E-67 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.289 1.01E-65 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.281 4.00E-62 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.275 2.20E-59 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.267 7.35E-56 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype