YBL027W / RPL19B

Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL027W / RPL19B

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.62|P-value:2.76E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-6.30|P-value:7.10E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:5.48|P-value:3.55E-8 ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.35|P-value:7.05E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.56|P-value:3.40E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.98|P-value:4.10E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.06|P-value:2.98E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.40|P-value:3.72E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.47|P-value:5.13E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.38|P-value:7.82E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.92|P-value:5.58E-12 ID:SGTC_1184|Compound:1269-1718|FD-Score:5.92|P-value:3.02E-9 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.98|P-value:4.69E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.37|P-value:6.73E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.43|P-value:6.14E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.49|P-value:4.65E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.98|P-value:7.21E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.52|P-value:3.94E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.25|P-value:9.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.99|P-value:3.98E-5 ID:SGTC_1906|Compound:st060206|FD-Score:-4.40|P-value:1.28E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.06|P-value:5.17E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.75|P-value:7.65E-9 ID:SGTC_2167|Compound:5876490|FD-Score:3.52|P-value:2.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.71|P-value:1.97E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.76|P-value:1.00E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.87|P-value:3.88E-9 ID:SGTC_2919|Compound:7978188|FD-Score:3.53|P-value:2.39E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:4.52E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.39|P-value:3.92E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.81|P-value:8.09E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-6.10|P-value:2.27E-9 ID:SGTC_3294|Compound:9122953|FD-Score:-3.40|P-value:5.95E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.89|P-value:7.21E-7 ID:SGTC_3|Compound:0833-0587|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.62|P-value:2.76E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-6.30|P-value:7.10E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:5.48|P-value:3.55E-8 ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.35|P-value:7.05E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.56|P-value:3.40E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.98|P-value:4.10E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.06|P-value:2.98E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.40|P-value:3.72E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.47|P-value:5.13E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.38|P-value:7.82E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.92|P-value:5.58E-12 ID:SGTC_1184|Compound:1269-1718|FD-Score:5.92|P-value:3.02E-9 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.98|P-value:4.69E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.37|P-value:6.73E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.43|P-value:6.14E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.49|P-value:4.65E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.98|P-value:7.21E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.52|P-value:3.94E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.25|P-value:9.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.99|P-value:3.98E-5 ID:SGTC_1906|Compound:st060206|FD-Score:-4.40|P-value:1.28E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.06|P-value:5.17E-5 ID:SGTC_2080|Compound:5212524|FD-Score:5.75|P-value:7.65E-9 ID:SGTC_2167|Compound:5876490|FD-Score:3.52|P-value:2.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.71|P-value:1.97E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.76|P-value:1.00E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.87|P-value:3.88E-9 ID:SGTC_2919|Compound:7978188|FD-Score:3.53|P-value:2.39E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.96|P-value:4.52E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.39|P-value:3.92E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.81|P-value:8.09E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-6.10|P-value:2.27E-9 ID:SGTC_3294|Compound:9122953|FD-Score:-3.40|P-value:5.95E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.89|P-value:7.21E-7

Top fitness defect scores for YBL027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1179 1021-1431 6.92 9.3 µM 5.58E-12 10 2.28E-12
2 SGTC_1184 1269-1718 5.92 139.0 µM 3.02E-9 7 1.65E-9
3 SGTC_2630 antimycin a 5.87 100.0 µM 3.88E-9 mitochondrial processes 14 2.15E-9
4 SGTC_2080 5212524 5.75 12.4 µM 7.65E-9 copper-dependent oxidative stress 4 4.38E-9
5 SGTC_118 0083-0097 5.48 135.3 µM 3.55E-8 translation 38 2.18E-8
6 SGTC_1332 1480-0653 4.98 17.5 µM 4.69E-7 TSC3-RPN4 7 3.22E-7
7 SGTC_3347 9188721 4.89 44.7 µM 7.21E-7 11 5.04E-7
8 SGTC_1576 erythromycin ethylsuccinate 4.49 23.2 µM 4.65E-6 14 3.52E-6
9 SGTC_937 3122-0005 4.47 46.7 µM 5.13E-6 15 3.89E-6
10 SGTC_1562 morin hydrate 4.43 59.1 µM 6.14E-6 9 4.70E-6
11 SGTC_945 3381-0768 4.38 11.3 µM 7.82E-6 endomembrane recycling 26 6.05E-6
12 SGTC_832 4083-0019 4.06 164.0 µM 2.98E-5 translation 89 2.43E-5
13 SGTC_1894 3',6'-dihydroxyflavone 3.99 78.7 µM 3.98E-5 11 3.28E-5
14 SGTC_822 1487-0950 3.98 154.0 µM 4.10E-5 10 3.39E-5
15 SGTC_2996 9066192 3.96 71.4 µM 4.52E-5 35 3.75E-5
16 SGTC_3142 9086498 3.81 49.5 µM 8.09E-5 iron homeostasis 41 6.87E-5
17 SGTC_2274 7947094 3.76 46.1 µM 1.00E-4 42 8.60E-5
18 SGTC_1570 verbenone 3.74 133.0 µM 1.05E-4 22 9.04E-5
19 SGTC_3133 9127736 3.68 49.5 µM 1.36E-4 26 1.18E-4
20 SGTC_3 0833-0587 3.64 95.6 µM 1.55E-4 redox potentiating 29 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.31E-13 YDR017C KCS1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
0.117 1.25E-11 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.115 2.64E-11 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.112 9.77E-11 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.103 2.05E-9 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.096 2.18E-8 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.096 2.26E-8 YKL097C_d YKL097C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.096 2.80E-8 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.095 3.46E-8 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.092 1.04E-7 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.088 3.13E-7 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.087 4.89E-7 YEL029C BUD16 hom Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)
0.086 6.89E-7 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.085 9.02E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.083 1.64E-6 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C