YBL029C-A

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL029C-A / YBL029C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YBL029C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 7.01 42.4 µM 5.31E-13 113 1.20E-12
2 SGTC_853 0419-0306 4.95 21.0 µM 2.50E-7 4 3.63E-7
3 SGTC_823 0417-1665 4.92 178.0 µM 3.04E-7 26 4.38E-7
4 SGTC_279 1273-0055 4.79 2.9 µM 5.96E-7 azole & statin 25 8.40E-7
5 SGTC_2909 7941780 4.76 10.5 µM 6.93E-7 5 9.71E-7
6 SGTC_2907 7721985 4.69 69.9 µM 9.67E-7 7 1.34E-6
7 SGTC_456 gingerol 4.50 170.0 µM 2.54E-6 10 3.41E-6
8 SGTC_2572 astragaloside iv 4.50 100.0 µM 2.54E-6 14 3.41E-6
9 SGTC_538 2922-0838 4.41 53.3 µM 3.84E-6 Golgi 23 5.10E-6
10 SGTC_2030 5175110 4.29 200.0 µM 6.99E-6 Golgi 22 9.10E-6
11 SGTC_2179 6298986 4.26 200.0 µM 7.78E-6 heme requiring 15 1.01E-5
12 SGTC_646 4092-0839 4.19 27.3 µM 1.09E-5 plasma membrane duress 23 1.39E-5
13 SGTC_719 2810-4230 4.13 27.3 µM 1.41E-5 8 1.79E-5
14 SGTC_1630 st005209 4.13 31.3 µM 1.42E-5 21 1.80E-5
15 SGTC_236 1509-0011 4.06 5.3 µM 1.93E-5 376 2.43E-5
16 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.00 100.0 µM 2.51E-5 20 3.13E-5
17 SGTC_2833 9001315 3.83 45.5 µM 5.20E-5 amide catabolism 60 6.35E-5
18 SGTC_453 enantio-paf c16 3.82 10.0 µM 5.54E-5 156 6.75E-5
19 SGTC_2892 9047358 3.69 58.4 µM 9.43E-5 13 1.13E-4
20 SGTC_2386 9075165 3.55 157.4 µM 1.66E-4 16 1.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 6.11E-48 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.234 4.55E-43 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.228 5.90E-41 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.219 7.58E-38 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.217 4.54E-37 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.216 7.84E-37 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.210 6.83E-35 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.210 7.00E-35 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.209 2.76E-34 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.206 1.42E-33 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.205 4.17E-33 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.198 4.31E-31 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.195 3.68E-30 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.195 3.90E-30 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.193 1.91E-29 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p