YBL030C / PET9

Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL030C / PET9

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:6.63|P-value:1.08E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.03|P-value:1.41E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.10|P-value:1.09E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.59|P-value:2.33E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:4.29|P-value:5.61E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.71|P-value:4.17E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:5.40|P-value:5.60E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.76|P-value:3.56E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.01E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.90|P-value:4.93E-6 ID:SGTC_1793|Compound:st048256|FD-Score:-4.52|P-value:1.97E-5 ID:SGTC_1799|Compound:st045822|FD-Score:-4.14|P-value:8.23E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.83|P-value:2.83E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.11|P-value:1.07E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.74|P-value:3.82E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.48|P-value:8.69E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.76|P-value:8.79E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.78|P-value:3.38E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.55|P-value:6.93E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.06|P-value:2.15E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:6.63|P-value:1.08E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.03|P-value:1.41E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.10|P-value:1.09E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.59|P-value:2.33E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:4.29|P-value:5.61E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.71|P-value:4.17E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:5.40|P-value:5.60E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.76|P-value:3.56E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.01E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.90|P-value:4.93E-6 ID:SGTC_1793|Compound:st048256|FD-Score:-4.52|P-value:1.97E-5 ID:SGTC_1799|Compound:st045822|FD-Score:-4.14|P-value:8.23E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.83|P-value:2.83E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.11|P-value:1.07E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.74|P-value:3.82E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.48|P-value:8.69E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.76|P-value:8.79E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.78|P-value:3.38E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.55|P-value:6.93E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.06|P-value:2.15E-6

Top fitness defect scores for YBL030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_69 0096-0274 6.63 206.7 µM 1.08E-9 mitochondrial processes 15 1.64E-11 0.00
2 SGTC_173 1273-0061 5.59 2.7 µM 2.33E-7 mitochondrial stress 8 1.15E-8 0.03
3 SGTC_818 4072-2707 5.40 53.5 µM 5.60E-7 3 3.33E-8 0.72
4 SGTC_1256 0570-0116 4.90 285.0 µM 4.93E-6 2 4.71E-7 0.59
5 SGTC_2630 antimycin a 4.76 100.0 µM 8.79E-6 mitochondrial processes 4 9.50E-7 0.06
6 SGTC_236 1509-0011 4.29 5.3 µM 5.61E-5 24 9.02E-6 0.18
7 SGTC_2370 9071495 4.11 200.0 µM 1.07E-4 mitochondrial processes 8 1.98E-5 0.14
8 SGTC_119 0121-0043 4.10 24.8 µM 1.09E-4 mitochondrial stress 20 2.03E-5 0.08
9 SGTC_70 0141-0289 4.03 43.3 µM 1.41E-4 mitochondrial stress 17 2.77E-5 0.01
10 SGTC_2104 5389443 3.83 200.0 µM 2.83E-4 7 6.43E-5 0.01
11 SGTC_1170 0310-0127 3.81 64.8 µM 3.01E-4 10 6.94E-5 0.03
12 SGTC_2645 abamectin 3.78 100.0 µM 3.38E-4 heme requiring 14 7.97E-5 0.07
13 SGTC_1131 3454-3128 3.76 32.3 µM 3.56E-4 17 8.49E-5 0.09
14 SGTC_2418 pentamidine 3.74 31.7 µM 3.82E-4 mitochondrial processes 16 9.25E-5 0.05
15 SGTC_410 α-linolenic acid 3.71 100.0 µM 4.17E-4 excess fatty acid 7 1.03E-4 0.07
16 SGTC_2659 sanguinarine 3.55 24.2 µM 6.93E-4 14 1.90E-4 0.20
17 SGTC_2448 5185112 3.48 27.2 µM 8.69E-4 9 2.51E-4 0.20
18 SGTC_566 0958-0068 3.43 16.5 µM 0.00102 RSC & ERG11 22 3.03E-4 0.03
19 SGTC_1197 1601-0112 3.41 267.0 µM 0.00108 10 3.27E-4 0.03
20 SGTC_123 0083-0120 3.38 66.7 µM 0.00119 17 3.66E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.40E-32 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.193 2.35E-29 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.186 2.33E-27 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.184 4.62E-27 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.184 6.31E-27 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.175 1.57E-24 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.173 6.69E-24 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.173 7.33E-24 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.172 8.33E-24 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.171 1.76E-23 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.169 6.51E-23 YJR121W ATP2 hom Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.169 6.56E-23 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.167 2.19E-22 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.167 3.55E-22 YDR322W MRPL35 hom Mitochondrial ribosomal protein of the large subunit
0.167 2.47E-22 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase