YBL031W / SHE1

Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL031W / SHE1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.92|P-value:9.49E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.38|P-value:1.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:9.73E-52 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.03|P-value:4.86E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.86|P-value:2.22E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.57|P-value:8.21E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.65|P-value:5.71E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.03|P-value:1.02E-5 ID:SGTC_441|Compound:propafenone|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.81|P-value:1.77E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.92|P-value:1.71E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.47|P-value:3.16E-9 ID:SGTC_652|Compound:0437-0092|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.44|P-value:3.90E-9 ID:SGTC_787|Compound:4152-0075|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.78|P-value:3.28E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.79|P-value:1.90E-7 ID:SGTC_959|Compound:1222-0044|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.95|P-value:7.67E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:2.79E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.95|P-value:9.39E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.53|P-value:9.92E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.41|P-value:1.56E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.00|P-value:1.18E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.62|P-value:6.47E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.88|P-value:1.18E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.86|P-value:2.27E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.19|P-value:3.93E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.68|P-value:3.58E-7 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.96|P-value:9.20E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-2.96|P-value:6.47E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-4.39|P-value:1.01E-6 ID:SGTC_1567|Compound:st069303|FD-Score:4.65|P-value:4.18E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.18|P-value:1.95E-8 ID:SGTC_1674|Compound:st016616|FD-Score:3.66|P-value:5.58E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.64|P-value:4.36E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.13|P-value:6.36E-6 ID:SGTC_1817|Compound:st052116|FD-Score:3.38|P-value:1.83E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.90|P-value:1.84E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.17|P-value:4.15E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.11|P-value:6.98E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.45|P-value:1.21E-6 ID:SGTC_2057|Compound:5236571|FD-Score:5.17|P-value:2.10E-8 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.52|P-value:1.01E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.58|P-value:6.04E-7 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:7.14E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.53|P-value:9.84E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.32|P-value:2.27E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.13|P-value:2.65E-8 ID:SGTC_2330|Compound:7979373|FD-Score:7.69|P-value:1.41E-16 ID:SGTC_2345|Compound:9052315|FD-Score:7.08|P-value:2.50E-14 ID:SGTC_2347|Compound:9049783|FD-Score:4.17|P-value:5.10E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.68|P-value:5.09E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:3.01E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.58|P-value:7.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.70|P-value:7.07E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:3.98|P-value:1.27E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.76|P-value:3.51E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.22|P-value:3.92E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.70|P-value:4.66E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.68|P-value:5.01E-5 ID:SGTC_2784|Compound:7567673|FD-Score:2.96|P-value:9.22E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.52|P-value:6.52E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-2.86|P-value:9.33E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.56|P-value:6.78E-7 ID:SGTC_2985|Compound:9022375|FD-Score:6.26|P-value:1.52E-11 ID:SGTC_3011|Compound:9081274|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.19|P-value:4.66E-6 ID:SGTC_3179|Compound:9107801|FD-Score:2.95|P-value:9.66E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.73|P-value:6.09E-10 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:1.59E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.92|P-value:9.49E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.38|P-value:1.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:9.73E-52 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.03|P-value:4.86E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.86|P-value:2.22E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.57|P-value:8.21E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.65|P-value:5.71E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.03|P-value:1.02E-5 ID:SGTC_441|Compound:propafenone|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.81|P-value:1.77E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.92|P-value:1.71E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.47|P-value:3.16E-9 ID:SGTC_652|Compound:0437-0092|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.44|P-value:3.90E-9 ID:SGTC_787|Compound:4152-0075|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.78|P-value:3.28E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.79|P-value:1.90E-7 ID:SGTC_959|Compound:1222-0044|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.95|P-value:7.67E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:2.79E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.95|P-value:9.39E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.53|P-value:9.92E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.41|P-value:1.56E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.00|P-value:1.18E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.62|P-value:6.47E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.88|P-value:1.18E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.86|P-value:2.27E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.19|P-value:3.93E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.68|P-value:3.58E-7 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.96|P-value:9.20E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-2.96|P-value:6.47E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-4.39|P-value:1.01E-6 ID:SGTC_1567|Compound:st069303|FD-Score:4.65|P-value:4.18E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.18|P-value:1.95E-8 ID:SGTC_1674|Compound:st016616|FD-Score:3.66|P-value:5.58E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.64|P-value:4.36E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.13|P-value:6.36E-6 ID:SGTC_1817|Compound:st052116|FD-Score:3.38|P-value:1.83E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.90|P-value:1.84E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.17|P-value:4.15E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.11|P-value:6.98E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.45|P-value:1.21E-6 ID:SGTC_2057|Compound:5236571|FD-Score:5.17|P-value:2.10E-8 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.52|P-value:1.01E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.58|P-value:6.04E-7 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:7.14E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.53|P-value:9.84E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.32|P-value:2.27E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.13|P-value:2.65E-8 ID:SGTC_2330|Compound:7979373|FD-Score:7.69|P-value:1.41E-16 ID:SGTC_2345|Compound:9052315|FD-Score:7.08|P-value:2.50E-14 ID:SGTC_2347|Compound:9049783|FD-Score:4.17|P-value:5.10E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.68|P-value:5.09E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:3.01E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.58|P-value:7.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.70|P-value:7.07E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:3.98|P-value:1.27E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.76|P-value:3.51E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.22|P-value:3.92E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.70|P-value:4.66E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.68|P-value:5.01E-5 ID:SGTC_2784|Compound:7567673|FD-Score:2.96|P-value:9.22E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.52|P-value:6.52E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-2.86|P-value:9.33E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.56|P-value:6.78E-7 ID:SGTC_2985|Compound:9022375|FD-Score:6.26|P-value:1.52E-11 ID:SGTC_3011|Compound:9081274|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.19|P-value:4.66E-6 ID:SGTC_3179|Compound:9107801|FD-Score:2.95|P-value:9.66E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.73|P-value:6.09E-10 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:1.59E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.32|P-value:2.32E-4

Top fitness defect scores for YBL031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 14.10 40.9 µM 9.73E-52 cell wall 18 1.03E-45
2 SGTC_2330 7979373 7.69 200.0 µM 1.41E-16 60S ribosome export 6 7.28E-15
3 SGTC_2345 9052315 7.08 157.4 µM 2.50E-14 2 6.96E-13
4 SGTC_2985 9022375 6.26 71.4 µM 1.52E-11 RPP1 & pyrimidine depletion 4 1.97E-10
5 SGTC_3266 9136860 5.73 49.5 µM 6.09E-10 cell wall 19 5.12E-9
6 SGTC_2582 agaric acid 5.70 100.0 µM 7.07E-10 redox potentiating 177 5.84E-9
7 SGTC_586 0957-0265 5.47 8.2 µM 3.16E-9 cell wall 21 2.19E-8
8 SGTC_713 1488-1073 5.44 324.0 µM 3.90E-9 ERG2 5 2.64E-8
9 SGTC_1586 deoxycorticosterone acetate 5.18 53.7 µM 1.95E-8 3 1.10E-7
10 SGTC_2057 5236571 5.17 38.3 µM 2.10E-8 RPP1 & pyrimidine depletion 10 1.17E-7
11 SGTC_2292 7671323 5.13 168.1 µM 2.65E-8 RNA processing & uracil transport 14 1.43E-7
12 SGTC_967 1306-0166 4.95 352.0 µM 7.67E-8 13 3.67E-7
13 SGTC_58 0957-0393 4.92 9.0 µM 9.49E-8 cell wall 293 4.43E-7
14 SGTC_1277 0873-0036 4.88 22.0 µM 1.18E-7 PDR1 13 5.37E-7
15 SGTC_576 1073-0113 4.81 22.7 µM 1.77E-7 redox potentiating 44 7.69E-7
16 SGTC_951 1171-0579 4.79 82.7 µM 1.90E-7 cell wall 49 8.21E-7
17 SGTC_1394 3474-0001 4.68 65.7 µM 3.58E-7 endomembrane recycling 25 1.44E-6
18 SGTC_1567 st069303 4.65 68.4 µM 4.18E-7 mitochondrial processes 6 1.65E-6
19 SGTC_1707 st032323 4.64 6.3 µM 4.36E-7 DNA damage response 42 1.71E-6
20 SGTC_2062 5245942 4.58 200.0 µM 6.04E-7 5 2.28E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 3.50E-79 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.295 1.42E-68 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.293 2.34E-67 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.287 9.24E-65 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.278 1.47E-60 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.272 4.42E-58 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.269 1.17E-56 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.250 4.13E-49 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.246 1.73E-47 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.246 2.17E-47 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.245 3.41E-47 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.242 7.78E-46 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.241 1.04E-45 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.241 1.02E-45 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.238 1.79E-44 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate