YBL037W / APL3

Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL037W / APL3

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.40|P-value:3.91E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.28|P-value:4.49E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.32|P-value:5.99E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:4.57|P-value:1.80E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.69|P-value:8.91E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.09|P-value:1.71E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.38|P-value:4.40E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.04|P-value:1.61E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.13|P-value:7.53E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.36|P-value:3.33E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.50|P-value:2.56E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:4.02|P-value:2.29E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.48|P-value:2.06E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.23|P-value:5.21E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.98|P-value:2.70E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:4.16|P-value:1.22E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.97|P-value:2.87E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.99|P-value:2.53E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.43|P-value:2.54E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.25|P-value:4.85E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.47|P-value:1.39E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.01|P-value:1.87E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.63|P-value:5.56E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.21|P-value:5.61E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.76|P-value:6.71E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.58|P-value:1.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.81|P-value:5.55E-7 ID:SGTC_1719|Compound:st032227|FD-Score:-4.27|P-value:7.58E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.29|P-value:4.17E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.70|P-value:8.59E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-3.19|P-value:6.05E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.66|P-value:1.03E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.99|P-value:3.64E-20 ID:SGTC_2009|Compound:4012297|FD-Score:6.69|P-value:5.55E-12 ID:SGTC_2028|Compound:5153890|FD-Score:-5.23|P-value:5.83E-8 ID:SGTC_2030|Compound:5175110|FD-Score:9.33|P-value:1.40E-21 ID:SGTC_2038|Compound:4100038|FD-Score:-6.95|P-value:9.07E-13 ID:SGTC_2041|Compound:5107442|FD-Score:5.88|P-value:1.23E-9 ID:SGTC_2043|Compound:5101342|FD-Score:-6.04|P-value:4.50E-10 ID:SGTC_2044|Compound:5102272|FD-Score:-3.48|P-value:2.11E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_2048|Compound:5246248|FD-Score:3.95|P-value:2.99E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.24|P-value:5.09E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.10|P-value:8.10E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.19|P-value:5.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.75|P-value:6.98E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.18|P-value:6.40E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.84|P-value:4.89E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.66|P-value:1.03E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.17|P-value:7.87E-8 ID:SGTC_2823|Compound:7987624|FD-Score:4.96|P-value:2.46E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-3.12|P-value:7.83E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.13|P-value:7.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.98|P-value:2.69E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.19|P-value:5.95E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.18|P-value:1.09E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-7.66|P-value:4.15E-15 ID:SGTC_2990|Compound:9074105|FD-Score:-3.63|P-value:1.19E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.99|P-value:2.61E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.20|P-value:5.86E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.40|P-value:3.91E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.28|P-value:4.49E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.32|P-value:5.99E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:4.57|P-value:1.80E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:3.69|P-value:8.91E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.09|P-value:1.71E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.38|P-value:4.40E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.04|P-value:1.61E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.13|P-value:7.53E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.36|P-value:3.33E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.50|P-value:2.56E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:4.02|P-value:2.29E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.48|P-value:2.06E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.23|P-value:5.21E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.98|P-value:2.70E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:4.16|P-value:1.22E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.97|P-value:2.87E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.99|P-value:2.53E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.43|P-value:2.54E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.25|P-value:4.85E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.47|P-value:1.39E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.01|P-value:1.87E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.63|P-value:5.56E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.21|P-value:5.61E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.76|P-value:6.71E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.58|P-value:1.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.81|P-value:5.55E-7 ID:SGTC_1719|Compound:st032227|FD-Score:-4.27|P-value:7.58E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.29|P-value:4.17E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.70|P-value:8.59E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-3.19|P-value:6.05E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.66|P-value:1.03E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.99|P-value:3.64E-20 ID:SGTC_2009|Compound:4012297|FD-Score:6.69|P-value:5.55E-12 ID:SGTC_2028|Compound:5153890|FD-Score:-5.23|P-value:5.83E-8 ID:SGTC_2030|Compound:5175110|FD-Score:9.33|P-value:1.40E-21 ID:SGTC_2038|Compound:4100038|FD-Score:-6.95|P-value:9.07E-13 ID:SGTC_2041|Compound:5107442|FD-Score:5.88|P-value:1.23E-9 ID:SGTC_2043|Compound:5101342|FD-Score:-6.04|P-value:4.50E-10 ID:SGTC_2044|Compound:5102272|FD-Score:-3.48|P-value:2.11E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_2048|Compound:5246248|FD-Score:3.95|P-value:2.99E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.24|P-value:5.09E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.10|P-value:8.10E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.19|P-value:5.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.75|P-value:6.98E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.18|P-value:6.40E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.84|P-value:4.89E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.66|P-value:1.03E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.17|P-value:7.87E-8 ID:SGTC_2823|Compound:7987624|FD-Score:4.96|P-value:2.46E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-3.12|P-value:7.83E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.13|P-value:7.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.98|P-value:2.69E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.19|P-value:5.95E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.18|P-value:1.09E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-7.66|P-value:4.15E-15 ID:SGTC_2990|Compound:9074105|FD-Score:-3.63|P-value:1.19E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.99|P-value:2.61E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.20|P-value:5.86E-4

Top fitness defect scores for YBL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2030 5175110 9.33 200.0 µM 1.40E-21 Golgi 1 5.12E-21
2 SGTC_2007 4011539 8.99 71.8 µM 3.64E-20 cell wall signaling 15 1.22E-19
3 SGTC_2009 4012297 6.69 12.1 µM 5.55E-12 cell wall signaling 20 1.09E-11
4 SGTC_2041 5107442 5.88 45.3 µM 1.23E-9 RSC complex & mRNA processing 10 2.09E-9
5 SGTC_1135 dihydrocapsaicin 5.63 536.7 nM 5.56E-9 7 9.04E-9
6 SGTC_1122 capsaicin 5.47 818.6 nM 1.39E-8 5 2.21E-8
7 SGTC_2814 7977482 5.17 43.0 µM 7.87E-8 16 1.19E-7
8 SGTC_450 aminopyrene 5.04 156.0 nM 1.61E-7 17 2.38E-7
9 SGTC_2823 7987624 4.96 58.4 µM 2.46E-7 9 3.60E-7
10 SGTC_2399 5884133 4.75 200.0 µM 6.98E-7 cell wall signaling 47 9.94E-7
11 SGTC_344 k064-0035 4.57 6.4 µM 1.80E-6 60S ribosome export 15 2.49E-6
12 SGTC_39 0986-0283 4.40 58.4 µM 3.91E-6 calcium & mitochondrial duress 23 5.31E-6
13 SGTC_390 dec-rvkr-cmk 4.38 16.7 µM 4.40E-6 calcium & mitochondrial duress 14 5.96E-6
14 SGTC_2045 5106652 4.37 78.0 µM 4.50E-6 7 6.08E-6
15 SGTC_2974 9094440 4.18 9.7 µM 1.09E-5 ergosterol biosynthesis 39 1.44E-5
16 SGTC_853 0419-0306 4.16 21.0 µM 1.22E-5 11 1.60E-5
17 SGTC_680 0417-1641 4.02 114.0 µM 2.29E-5 RPP1 & pyrimidine depletion 10 2.97E-5
18 SGTC_990 3985-0011 3.99 41.3 µM 2.53E-5 amide catabolism 19 3.26E-5
19 SGTC_3072 9116419 3.99 49.5 µM 2.61E-5 ERG2 15 3.37E-5
20 SGTC_801 0866-0028 3.98 10.1 µM 2.70E-5 27 3.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 2.28E-29 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.165 6.77E-22 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.158 4.05E-20 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.136 2.70E-15 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.133 1.16E-14 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.128 1.17E-13 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.128 1.18E-13 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.127 1.78E-13 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.117 9.28E-12 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.112 7.64E-11 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.111 9.64E-11 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099 8.28E-9 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.097 1.79E-8 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.096 2.56E-8 YIL012W_d YIL012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.20E-8 YNL139C THO2 hom Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids