YBL038W / MRPL16

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL038W / MRPL16

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.21|P-value:8.54E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.88|P-value:2.18E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.94|P-value:3.73E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.13|P-value:1.61E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:7.64|P-value:1.93E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:5.93E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:4.21|P-value:6.76E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.99|P-value:2.97E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:3.96|P-value:1.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:2.51E-24 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.27|P-value:8.74E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:4.02|P-value:1.34E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.78|P-value:3.05E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.47|P-value:7.03E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:4.60|P-value:1.49E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.24|P-value:6.08E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.96|P-value:2.90E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.23|P-value:5.43E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.58|P-value:5.96E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.48|P-value:8.06E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.64|P-value:1.29E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:8.03E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.68|P-value:4.31E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.47|P-value:8.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.52|P-value:7.17E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.51|P-value:7.48E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-4.29|P-value:4.38E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:4.30|P-value:4.89E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.92|P-value:1.65E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.35|P-value:4.06E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.93|P-value:1.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.98|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:3.03E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.53|P-value:6.84E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.42|P-value:9.65E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.50|P-value:7.54E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:6.05|P-value:1.96E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.70|P-value:3.94E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.41|P-value:3.16E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.09|P-value:9.02E-5 ID:SGTC_1622|Compound:st003707|FD-Score:8.69|P-value:1.43E-15 ID:SGTC_1623|Compound:st003709|FD-Score:8.23|P-value:3.83E-14 ID:SGTC_1624|Compound:st003710|FD-Score:7.25|P-value:2.20E-11 ID:SGTC_1627|Compound:st003713|FD-Score:4.54|P-value:1.94E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-3.90|P-value:1.78E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.05|P-value:1.07E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.48|P-value:8.04E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.51|P-value:1.37E-9 ID:SGTC_1731|Compound:st035964|FD-Score:-4.02|P-value:1.19E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.30|P-value:4.87E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.82|P-value:2.36E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.55|P-value:1.56E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.68|P-value:4.28E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.41|P-value:3.16E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:4.57E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.44|P-value:2.81E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.62|P-value:4.65E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.51|P-value:6.56E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.24|P-value:7.50E-9 ID:SGTC_2276|Compound:7947513|FD-Score:4.16|P-value:8.08E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.65|P-value:4.76E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.74|P-value:8.56E-6 ID:SGTC_2353|Compound:9059630|FD-Score:4.93|P-value:3.93E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.00|P-value:2.61E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.97|P-value:1.60E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.56|P-value:6.20E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.97|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.56|P-value:5.60E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.74E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.69|P-value:1.06E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-5.12|P-value:1.43E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.50|P-value:7.51E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.76|P-value:3.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.08|P-value:1.43E-8 ID:SGTC_2989|Compound:9073649|FD-Score:-3.58|P-value:5.16E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.60|P-value:5.60E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.43|P-value:2.93E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.08|P-value:9.47E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.02|P-value:2.66E-6 ID:SGTC_3347|Compound:9188721|FD-Score:4.05|P-value:1.20E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.21|P-value:8.54E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.88|P-value:2.18E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.94|P-value:3.73E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.13|P-value:1.61E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:7.64|P-value:1.93E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:5.93E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:4.21|P-value:6.76E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.99|P-value:2.97E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:3.96|P-value:1.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:2.51E-24 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.27|P-value:8.74E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:4.02|P-value:1.34E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.78|P-value:3.05E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.47|P-value:7.03E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:4.60|P-value:1.49E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.24|P-value:6.08E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.96|P-value:2.90E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.23|P-value:5.43E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.58|P-value:5.96E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.48|P-value:8.06E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.64|P-value:1.29E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:8.03E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.68|P-value:4.31E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.47|P-value:8.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.52|P-value:7.17E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.51|P-value:7.48E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-4.29|P-value:4.38E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:4.30|P-value:4.89E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.92|P-value:1.65E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.35|P-value:4.06E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.93|P-value:1.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.98|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:3.03E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.53|P-value:6.84E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.42|P-value:9.65E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.50|P-value:7.54E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:6.05|P-value:1.96E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.70|P-value:3.94E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.41|P-value:3.16E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.09|P-value:9.02E-5 ID:SGTC_1622|Compound:st003707|FD-Score:8.69|P-value:1.43E-15 ID:SGTC_1623|Compound:st003709|FD-Score:8.23|P-value:3.83E-14 ID:SGTC_1624|Compound:st003710|FD-Score:7.25|P-value:2.20E-11 ID:SGTC_1627|Compound:st003713|FD-Score:4.54|P-value:1.94E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-3.90|P-value:1.78E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.05|P-value:1.07E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.48|P-value:8.04E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.51|P-value:1.37E-9 ID:SGTC_1731|Compound:st035964|FD-Score:-4.02|P-value:1.19E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.30|P-value:4.87E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.82|P-value:2.36E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.55|P-value:1.56E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.68|P-value:4.28E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.41|P-value:3.16E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:4.57E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.44|P-value:2.81E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.62|P-value:4.65E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.51|P-value:6.56E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.24|P-value:7.50E-9 ID:SGTC_2276|Compound:7947513|FD-Score:4.16|P-value:8.08E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.65|P-value:4.76E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.74|P-value:8.56E-6 ID:SGTC_2353|Compound:9059630|FD-Score:4.93|P-value:3.93E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.00|P-value:2.61E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.97|P-value:1.60E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.56|P-value:6.20E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.97|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.56|P-value:5.60E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.74E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.69|P-value:1.06E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-5.12|P-value:1.43E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.50|P-value:7.51E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.76|P-value:3.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.08|P-value:1.43E-8 ID:SGTC_2989|Compound:9073649|FD-Score:-3.58|P-value:5.16E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.60|P-value:5.60E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.43|P-value:2.93E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.08|P-value:9.47E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.02|P-value:2.66E-6 ID:SGTC_3347|Compound:9188721|FD-Score:4.05|P-value:1.20E-4

Top fitness defect scores for YBL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.10 5.3 µM 2.51E-24 171 5.06E-29
2 SGTC_1622 st003707 8.69 19.4 µM 1.43E-15 calcium & mitochondrial duress 7 1.82E-18
3 SGTC_310 1273-0058 8.47 1.1 µM 7.03E-15 mitochondrial stress 75 1.24E-17
4 SGTC_1623 st003709 8.23 20.3 µM 3.83E-14 calcium & mitochondrial duress 5 9.55E-17
5 SGTC_161 4065-0411 7.64 162.2 µM 1.93E-12 19 1.08E-14
6 SGTC_1624 st003710 7.25 6.2 µM 2.20E-11 calcium & mitochondrial duress 9 2.01E-13
7 SGTC_2250 alverine citrate 6.24 130.0 µM 7.50E-9 47 2.26E-10
8 SGTC_10 0279-0212 6.21 42.6 µM 8.54E-9 TRP & mitochondrial translation 25 2.64E-10
9 SGTC_1351 1496-0003 6.05 46.5 µM 1.96E-8 3 7.17E-10
10 SGTC_2418 pentamidine 6.00 31.7 µM 2.61E-8 mitochondrial processes 14 1.01E-9
11 SGTC_275 trichlorophene 5.27 5.7 µM 8.74E-7 mitochondrial stress 152 6.90E-8
12 SGTC_58 0957-0393 5.13 9.0 µM 1.61E-6 cell wall 271 1.44E-7
13 SGTC_3307 9126885 5.02 69.3 µM 2.66E-6 16 2.63E-7
14 SGTC_204 1543-0184 4.99 62.4 µM 2.97E-6 TRP & mitochondrial translation 16 3.00E-7
15 SGTC_33 0986-0033 4.94 35.8 µM 3.73E-6 calcium & mitochondrial duress 11 3.95E-7
16 SGTC_2353 9059630 4.93 146.7 µM 3.93E-6 5 4.21E-7
17 SGTC_173 1273-0061 4.83 2.7 µM 5.93E-6 mitochondrial stress 156 6.90E-7
18 SGTC_2337 9009472 4.74 200.0 µM 8.56E-6 16 1.07E-6
19 SGTC_2700 st077718 4.69 96.8 µM 1.06E-5 6 1.39E-6
20 SGTC_582 0987-0078 4.64 156.0 µM 1.29E-5 calcium & mitochondrial duress 41 1.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.382 3.30E-117 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.379 5.39E-115 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.376 2.73E-113 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.375 2.20E-112 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.370 2.32E-109 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.369 1.35E-108 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.364 9.58E-106 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.362 1.32E-104 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.356 3.94E-100 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.355 2.28E-100 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.354 7.17E-100 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.354 9.36E-100 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.353 4.02E-99 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.351 1.04E-97 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.345 1.73E-94 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress