YBL039W-B_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL039W-B / YBL039W-B

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:2.96|P-value:9.50E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.55|P-value:9.60E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.07|P-value:6.27E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:2.98|P-value:8.64E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.43|P-value:1.94E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.83|P-value:2.95E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.59E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.45|P-value:1.45E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.96|P-value:1.62E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.65|P-value:8.00E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.37|P-value:2.50E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:5.87|P-value:4.05E-10 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.93|P-value:1.64E-7 ID:SGTC_529|Compound:4076-0302|FD-Score:-5.85|P-value:6.74E-10 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.09|P-value:6.59E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:-5.72|P-value:1.50E-9 ID:SGTC_537|Compound:1334-0398|FD-Score:3.40|P-value:1.81E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:2.97|P-value:9.01E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.01|P-value:7.83E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:2.99|P-value:8.31E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:5.79|P-value:7.09E-10 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.42|P-value:2.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.38|P-value:9.25E-9 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.00|P-value:8.19E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.49|P-value:1.65E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.19|P-value:4.03E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.37|P-value:2.48E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.07|P-value:7.66E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.24|P-value:4.39E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.16|P-value:4.59E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.36|P-value:2.10E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.10|P-value:5.68E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.18|P-value:4.22E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.06|P-value:6.65E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.09|P-value:7.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.50|P-value:5.99E-9 ID:SGTC_1816|Compound:st051957|FD-Score:3.09|P-value:5.94E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.60|P-value:8.03E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.77|P-value:3.78E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.13|P-value:5.11E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.28|P-value:2.84E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.11|P-value:5.47E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.02|P-value:7.42E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2337|Compound:9009472|FD-Score:5.15|P-value:3.54E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:4.01|P-value:1.30E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.46|P-value:1.48E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.92|P-value:1.75E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.75|P-value:1.26E-9 ID:SGTC_2835|Compound:9006588|FD-Score:3.95|P-value:1.76E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.30|P-value:3.25E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.49|P-value:1.27E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.53|P-value:1.32E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.86|P-value:3.21E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.62|P-value:7.22E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.09|P-value:7.00E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.42|P-value:1.83E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.53|P-value:1.05E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:2.96|P-value:9.50E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.55|P-value:9.60E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.07|P-value:6.27E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:2.98|P-value:8.64E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.43|P-value:1.94E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.83|P-value:2.95E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.59E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.45|P-value:1.45E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.96|P-value:1.62E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.65|P-value:8.00E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.37|P-value:2.50E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:5.87|P-value:4.05E-10 ID:SGTC_526|Compound:4469-0568|FD-Score:-4.93|P-value:1.64E-7 ID:SGTC_529|Compound:4076-0302|FD-Score:-5.85|P-value:6.74E-10 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.09|P-value:6.59E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:-5.72|P-value:1.50E-9 ID:SGTC_537|Compound:1334-0398|FD-Score:3.40|P-value:1.81E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:2.97|P-value:9.01E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.01|P-value:7.83E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:2.99|P-value:8.31E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:5.79|P-value:7.09E-10 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.42|P-value:2.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.38|P-value:9.25E-9 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.00|P-value:8.19E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.05|P-value:6.73E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.49|P-value:1.65E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.19|P-value:4.03E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.37|P-value:2.48E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.07|P-value:7.66E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.24|P-value:4.39E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.16|P-value:4.59E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.36|P-value:2.10E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.10|P-value:5.68E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.18|P-value:4.22E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.06|P-value:6.65E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.09|P-value:7.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.50|P-value:5.99E-9 ID:SGTC_1816|Compound:st051957|FD-Score:3.09|P-value:5.94E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.60|P-value:8.03E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.77|P-value:3.78E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.13|P-value:5.11E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.28|P-value:2.84E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.11|P-value:5.47E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.02|P-value:7.42E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2337|Compound:9009472|FD-Score:5.15|P-value:3.54E-8 ID:SGTC_2605|Compound:digitonin|FD-Score:4.01|P-value:1.30E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.46|P-value:1.48E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.92|P-value:1.75E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.75|P-value:1.26E-9 ID:SGTC_2835|Compound:9006588|FD-Score:3.95|P-value:1.76E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.30|P-value:3.25E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.49|P-value:1.27E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.53|P-value:1.32E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.86|P-value:3.21E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.62|P-value:7.22E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.09|P-value:7.00E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.42|P-value:1.83E-6 ID:SGTC_3340|Compound:9146634|FD-Score:3.53|P-value:1.05E-4

Top fitness defect scores for YBL039W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_523 1934-0222 5.87 13.7 µM 4.05E-10 8 2.15E-9
2 SGTC_759 3486-0358 5.79 89.3 µM 7.09E-10 3 3.59E-9
3 SGTC_950 1165-0508 5.38 94.1 µM 9.25E-9 8 3.82E-8
4 SGTC_2337 9009472 5.15 200.0 µM 3.54E-8 11 1.31E-7
5 SGTC_2606 farnesol 4.46 9.8 µM 1.48E-6 13 4.06E-6
6 SGTC_3316 9136639 4.42 10.6 µM 1.83E-6 10 4.96E-6
7 SGTC_1184 1269-1718 4.24 139.0 µM 4.39E-6 22 1.11E-5
8 SGTC_2605 digitonin 4.01 300.0 nM 1.30E-5 26 3.01E-5
9 SGTC_236 1509-0011 3.96 5.3 µM 1.62E-5 383 3.67E-5
10 SGTC_2835 9006588 3.95 71.4 µM 1.76E-5 39 3.97E-5
11 SGTC_153 4077-0274 3.83 519.7 µM 2.95E-5 16 6.40E-5
12 SGTC_1870 st057514 3.77 26.5 µM 3.78E-5 RSC & ERG11 29 8.03E-5
13 SGTC_3056 9094900 3.62 49.5 µM 7.22E-5 35 1.46E-4
14 SGTC_1863 st057641 3.60 20.1 µM 8.03E-5 21 1.61E-4
15 SGTC_58 0957-0393 3.55 9.0 µM 9.60E-5 cell wall 424 1.89E-4
16 SGTC_3340 9146634 3.53 11.1 µM 1.05E-4 24 2.05E-4
17 SGTC_2176 5809774 3.52 34.0 µM 1.09E-4 mitochondrial processes 25 2.13E-4
18 SGTC_1002 4049-0206 3.51 172.0 µM 1.16E-4 53 2.26E-4
19 SGTC_2944 9067346 3.49 25.6 µM 1.27E-4 43 2.45E-4
20 SGTC_2297 7971671 3.46 152.3 µM 1.40E-4 RNA processing & uracil transport 46 2.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.26E-10 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.104 1.59E-9 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.102 3.23E-9 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.101 4.23E-9 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.099 8.54E-9 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.097 1.59E-8 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.097 1.77E-8 YJR077C MIR1 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.096 2.67E-8 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.096 2.89E-8 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.095 3.09E-8 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.094 4.29E-8 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.091 1.31E-7 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.091 1.38E-7 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.24E-7 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.089 2.65E-7 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding