| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.108 |
3.26E-10 |
YML070W |
DAK1 |
hom |
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
| 0.104 |
1.59E-9 |
YER141W |
COX15 |
hom |
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
| 0.102 |
3.23E-9 |
YGL237C |
HAP2 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding |
| 0.101 |
4.23E-9 |
YHR050W-A_p |
YHR050W-A_p |
hom |
Protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.099 |
8.54E-9 |
YHL038C |
CBP2 |
hom |
Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene |
| 0.097 |
1.59E-8 |
YJR120W |
YJR120W |
hom |
Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p |
| 0.097 |
1.77E-8 |
YJR077C |
MIR1 |
hom |
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated |
| 0.096 |
2.67E-8 |
YPL215W |
CBP3 |
hom |
Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
| 0.096 |
2.89E-8 |
YOR330C |
MIP1 |
hom |
Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit |
| 0.095 |
3.09E-8 |
YNL211C_p |
YNL211C_p |
hom |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene |
| 0.094 |
4.29E-8 |
YJL166W |
QCR8 |
hom |
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
| 0.091 |
1.31E-7 |
YKL109W |
HAP4 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex |
| 0.091 |
1.38E-7 |
YJL023C |
PET130 |
hom |
Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.089 |
2.24E-7 |
YDR230W_d |
YDR230W_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 |
| 0.089 |
2.65E-7 |
YBL021C |
HAP3 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding |
