HIPHOP chemogenomics database

YBL040C / ERD2

HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins

Zygosity: Heterozygous strain

fixedexpanded
Profile for YBL040C / ERD2

Click on Significant Values for Screen Details

Top fitness defect scores for YBL040C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2332	7982454	4.62	138.9 µM	2.22E-7		8	1.96E-6	0.17
2	SGTC_2690	usnic acid	4.48	100.0 µM	4.90E-7		3	3.82E-6	0.34
3	SGTC_2941	9056145	4.15	11.2 µM	2.83E-6		10	1.66E-5	0.39
4	SGTC_255	tunicamycin	4.12	200.5 nM	3.23E-6	unfolded protein response	14	1.85E-5	0.31
5	SGTC_3067	9117431	3.96	49.5 µM	7.44E-6		8	3.74E-5	0.08
6	SGTC_2413	inermin	3.89	26.1 µM	1.06E-5		19	5.02E-5	0.04
7	SGTC_1789	tunicamycin	3.87	25.0 nM	1.17E-5	unfolded protein response	16	5.46E-5	0.12
8	SGTC_874	0599-0792	3.82	117.0 µM	1.48E-5		5	6.66E-5	0.14
9	SGTC_3257	9139206	3.76	33.0 µM	1.98E-5		5	8.52E-5	0.07
10	SGTC_2013	4024628	3.50	200.0 µM	6.57E-5		10	2.34E-4	0.09
11	SGTC_2442	5158906	3.34	48.5 µM	1.34E-4		3	4.25E-4	0.07
12	SGTC_1262	0737-0114	3.18	49.6 µM	2.53E-4		11	7.28E-4	0.03
13	SGTC_1309	pyrazolanthrone	3.18	13.4 µM	2.58E-4		17	7.41E-4	0.10
14	SGTC_1247	0448-0043	3.17	5.8 µM	2.62E-4	ERG2	19	7.50E-4	0.12
15	SGTC_3065	9113888	3.15	49.5 µM	2.95E-4		14	8.28E-4	0.06
16	SGTC_1233	0325-0408	3.11	14.2 µM	3.38E-4		13	9.29E-4	0.26
17	SGTC_873	0591-4978	3.11	488.0 µM	3.40E-4		8	9.35E-4	0.10
18	SGTC_1753	st043925	3.10	64.0 µM	3.54E-4		11	9.66E-4	0.09
19	SGTC_3236	9132701	3.05	49.5 µM	4.36E-4	TSC3-RPN4	12	0.00115	0.01
20	SGTC_1241	0364-0022	3.02	50.8 µM	4.92E-4	ERG2	12	0.00128	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.282	3.12E-62	YBR243C	ALG7	het	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.145	2.91E-17	YNL287W	SEC21	het	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.123	9.70E-13	YOR246C	ENV9	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.121	1.68E-12	YKL173W	SNU114	het	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.121	2.01E-12	YFL038C	YPT1	het	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.119	4.14E-12	YDR077W	SED1	hom	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
0.113	5.63E-11	YDL121C_p	YDL121C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.112	9.32E-11	YDR436W	PPZ2	hom	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.109	2.89E-10	YDL145C	COP1	het	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.106	6.65E-10	YLR349W_d	YLR349W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.105	9.29E-10	YKL104C	GFA1	het	Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.104	1.49E-9	YPL082C	MOT1	het	Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.101	5.48E-9	YFR042W	KEG1	het	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.096	2.50E-8	YDR238C	SEC26	het	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.096	2.68E-8	YJL051W	IRC8	hom	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc