YBL040C / ERD2

HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL040C / ERD2

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.07|P-value:3.49E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.12|P-value:3.23E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.15|P-value:2.55E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.82|P-value:9.13E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.83|P-value:9.05E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.00|P-value:5.32E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.08|P-value:3.49E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.00|P-value:4.71E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.71|P-value:2.18E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-6.01|P-value:1.88E-11 ID:SGTC_627|Compound:1391-0720|FD-Score:2.87|P-value:8.77E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-2.82|P-value:9.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:2.97|P-value:5.93E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.82|P-value:1.48E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.85|P-value:8.18E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.99|P-value:4.90E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.00|P-value:5.30E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.11|P-value:3.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.02|P-value:4.92E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.17|P-value:2.62E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.18|P-value:2.53E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.18|P-value:2.58E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:8.39E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.87|P-value:8.60E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.79|P-value:1.48E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.10|P-value:3.54E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-4.22|P-value:1.66E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.87|P-value:1.17E-5 ID:SGTC_1981|Compound:st071826|FD-Score:-3.88|P-value:9.32E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.50|P-value:6.57E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-5.89|P-value:4.66E-11 ID:SGTC_2238|Compound:6671620|FD-Score:-2.94|P-value:5.96E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.95|P-value:5.66E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-2.92|P-value:6.41E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.32|P-value:9.94E-7 ID:SGTC_2332|Compound:7982454|FD-Score:4.62|P-value:2.22E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.89|P-value:1.06E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.34|P-value:1.34E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.57|P-value:4.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.03|P-value:4.18E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.48|P-value:4.90E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.12|P-value:2.93E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:2.83E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.15|P-value:2.95E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.96|P-value:7.44E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.71|P-value:2.16E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-2.84|P-value:8.68E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.05|P-value:4.36E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.38|P-value:9.78E-5 ID:SGTC_3257|Compound:9139206|FD-Score:3.76|P-value:1.98E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.34|P-value:1.15E-4 ID:SGTC_3312|Compound:9133330|FD-Score:2.89|P-value:8.14E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.07|P-value:3.49E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.12|P-value:3.23E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.15|P-value:2.55E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.82|P-value:9.13E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.83|P-value:9.05E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.00|P-value:5.32E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.08|P-value:3.49E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.00|P-value:4.71E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.71|P-value:2.18E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-6.01|P-value:1.88E-11 ID:SGTC_627|Compound:1391-0720|FD-Score:2.87|P-value:8.77E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-2.82|P-value:9.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:2.97|P-value:5.93E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.82|P-value:1.48E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.85|P-value:8.18E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.99|P-value:4.90E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.00|P-value:5.30E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.11|P-value:3.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.02|P-value:4.92E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.17|P-value:2.62E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.18|P-value:2.53E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.18|P-value:2.58E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:8.39E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.87|P-value:8.60E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.79|P-value:1.48E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.10|P-value:3.54E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-4.22|P-value:1.66E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.87|P-value:1.17E-5 ID:SGTC_1981|Compound:st071826|FD-Score:-3.88|P-value:9.32E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.50|P-value:6.57E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-5.89|P-value:4.66E-11 ID:SGTC_2238|Compound:6671620|FD-Score:-2.94|P-value:5.96E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.95|P-value:5.66E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-2.92|P-value:6.41E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.32|P-value:9.94E-7 ID:SGTC_2332|Compound:7982454|FD-Score:4.62|P-value:2.22E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.89|P-value:1.06E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.34|P-value:1.34E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.57|P-value:4.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.03|P-value:4.18E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.48|P-value:4.90E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.12|P-value:2.93E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:2.83E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.15|P-value:2.95E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.96|P-value:7.44E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.71|P-value:2.16E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-2.84|P-value:8.68E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.05|P-value:4.36E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.38|P-value:9.78E-5 ID:SGTC_3257|Compound:9139206|FD-Score:3.76|P-value:1.98E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.34|P-value:1.15E-4 ID:SGTC_3312|Compound:9133330|FD-Score:2.89|P-value:8.14E-4

Top fitness defect scores for YBL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2332 7982454 4.62 138.9 µM 2.22E-7 8 1.96E-6 0.17
2 SGTC_2690 usnic acid 4.48 100.0 µM 4.90E-7 3 3.82E-6 0.34
3 SGTC_2941 9056145 4.15 11.2 µM 2.83E-6 10 1.66E-5 0.39
4 SGTC_255 tunicamycin 4.12 200.5 nM 3.23E-6 unfolded protein response 14 1.85E-5 0.31
5 SGTC_3067 9117431 3.96 49.5 µM 7.44E-6 8 3.74E-5 0.08
6 SGTC_2413 inermin 3.89 26.1 µM 1.06E-5 19 5.02E-5 0.04
7 SGTC_1789 tunicamycin 3.87 25.0 nM 1.17E-5 unfolded protein response 16 5.46E-5 0.12
8 SGTC_874 0599-0792 3.82 117.0 µM 1.48E-5 5 6.66E-5 0.14
9 SGTC_3257 9139206 3.76 33.0 µM 1.98E-5 5 8.52E-5 0.07
10 SGTC_2013 4024628 3.50 200.0 µM 6.57E-5 10 2.34E-4 0.09
11 SGTC_2442 5158906 3.34 48.5 µM 1.34E-4 3 4.25E-4 0.07
12 SGTC_1262 0737-0114 3.18 49.6 µM 2.53E-4 11 7.28E-4 0.03
13 SGTC_1309 pyrazolanthrone 3.18 13.4 µM 2.58E-4 17 7.41E-4 0.10
14 SGTC_1247 0448-0043 3.17 5.8 µM 2.62E-4 ERG2 19 7.50E-4 0.12
15 SGTC_3065 9113888 3.15 49.5 µM 2.95E-4 14 8.28E-4 0.06
16 SGTC_1233 0325-0408 3.11 14.2 µM 3.38E-4 13 9.29E-4 0.26
17 SGTC_873 0591-4978 3.11 488.0 µM 3.40E-4 8 9.35E-4 0.10
18 SGTC_1753 st043925 3.10 64.0 µM 3.54E-4 11 9.66E-4 0.09
19 SGTC_3236 9132701 3.05 49.5 µM 4.36E-4 TSC3-RPN4 12 0.00115 0.01
20 SGTC_1241 0364-0022 3.02 50.8 µM 4.92E-4 ERG2 12 0.00128 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 3.12E-62 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.145 2.91E-17 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.123 9.70E-13 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.121 1.68E-12 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.121 2.01E-12 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.119 4.14E-12 YDR077W SED1 hom Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
0.113 5.63E-11 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.112 9.32E-11 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.109 2.89E-10 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.106 6.65E-10 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.105 9.29E-10 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.104 1.49E-9 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.101 5.48E-9 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.096 2.50E-8 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.096 2.68E-8 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc