YBL041W / PRE7

Beta 6 subunit of the 20S proteasome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL041W / PRE7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.29|P-value:7.18E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.87|P-value:1.12E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:-5.71|P-value:1.28E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:7.61E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:18.00|P-value:8.67E-69 ID:SGTC_137|Compound:0438-0332|FD-Score:5.57|P-value:3.16E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.29|P-value:6.59E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.55|P-value:5.11E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:3.94|P-value:6.56E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.60|P-value:2.19E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.67|P-value:1.83E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.28|P-value:1.60E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.67|P-value:2.64E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.19|P-value:9.71E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.65|P-value:1.82E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.42|P-value:9.05E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.52|P-value:5.15E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.90|P-value:7.76E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:6.07|P-value:1.86E-9 ID:SGTC_879|Compound:0831-1030|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.79|P-value:1.63E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.60|P-value:2.22E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.54|P-value:2.75E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.51|P-value:3.03E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.33|P-value:1.12E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.42|P-value:4.21E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.56|P-value:4.70E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.51|P-value:3.33E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.31|P-value:6.61E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.15|P-value:2.76E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.17|P-value:1.05E-9 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:7.87E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.26|P-value:7.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.99|P-value:5.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.48|P-value:8.68E-17 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.39|P-value:4.75E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.21|P-value:9.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.45|P-value:3.75E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.47|P-value:3.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.09|P-value:3.82E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.28|P-value:7.20E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.25|P-value:7.61E-4 ID:SGTC_2956|Compound:9076196|FD-Score:4.67|P-value:2.96E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-3.41|P-value:4.37E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-10.40|P-value:2.31E-24 ID:SGTC_3037|Compound:9091026|FD-Score:3.32|P-value:6.33E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.07|P-value:3.86E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.39|P-value:4.95E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.54|P-value:2.71E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.31|P-value:6.20E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.29|P-value:7.18E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.87|P-value:1.12E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:-5.71|P-value:1.28E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:7.61E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:18.00|P-value:8.67E-69 ID:SGTC_137|Compound:0438-0332|FD-Score:5.57|P-value:3.16E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.29|P-value:6.59E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.55|P-value:5.11E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:3.94|P-value:6.56E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.60|P-value:2.19E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.67|P-value:1.83E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.28|P-value:1.60E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.67|P-value:2.64E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.19|P-value:9.71E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.65|P-value:1.82E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.42|P-value:9.05E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.52|P-value:5.15E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.90|P-value:7.76E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:6.07|P-value:1.86E-9 ID:SGTC_879|Compound:0831-1030|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.79|P-value:1.63E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.60|P-value:2.22E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.54|P-value:2.75E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.51|P-value:3.03E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.33|P-value:1.12E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.42|P-value:4.21E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.56|P-value:4.70E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.51|P-value:3.33E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.31|P-value:6.61E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.15|P-value:2.76E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.17|P-value:1.05E-9 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:7.87E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.26|P-value:7.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.99|P-value:5.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.48|P-value:8.68E-17 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.39|P-value:4.75E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.21|P-value:9.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.45|P-value:3.75E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.47|P-value:3.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.09|P-value:3.82E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.28|P-value:7.20E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.25|P-value:7.61E-4 ID:SGTC_2956|Compound:9076196|FD-Score:4.67|P-value:2.96E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-3.41|P-value:4.37E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-10.40|P-value:2.31E-24 ID:SGTC_3037|Compound:9091026|FD-Score:3.32|P-value:6.33E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.07|P-value:3.86E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.39|P-value:4.95E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.54|P-value:2.71E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.31|P-value:6.20E-4

Top fitness defect scores for YBL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_64 000l-0018 18.00 272.1 µM 8.67E-69 ubiquinone biosynthesis & proteasome 6 1.28E-72 2.27
2 SGTC_2250 alverine citrate 8.48 130.0 µM 8.68E-17 13 1.15E-17 0.96
3 SGTC_1597 7-benzyloxygramine 6.17 47.5 µM 1.05E-9 calcium & mitochondrial duress 33 3.51E-10 0.11
4 SGTC_878 0828-0289 6.07 13.7 µM 1.86E-9 10 6.39E-10 0.09
5 SGTC_137 0438-0332 5.57 85.4 µM 3.16E-8 ubiquinone biosynthesis & proteasome 20 1.28E-8 0.06
6 SGTC_1370 2001-0092 5.33 44.6 µM 1.12E-7 1 4.86E-8 0.77
7 SGTC_2679 rapamycin 5.13 1.0 nM 3.22E-7 34 1.48E-7 0.10
8 SGTC_2688 kanamycin b 5.09 96.7 µM 3.82E-7 calcium & mitochondrial duress 4 1.77E-7 0.12
9 SGTC_58 0957-0393 4.95 9.0 µM 7.61E-7 cell wall 40 3.67E-7 0.21
10 SGTC_54 0159-0055 4.87 9.0 µM 1.12E-6 ERG2 6 5.52E-7 0.71
11 SGTC_923 1900-2434 4.79 73.3 µM 1.63E-6 RNA processing & uracil transport 7 8.22E-7 0.24
12 SGTC_2956 9076196 4.67 2.5 µM 2.96E-6 3 1.54E-6 0.83
13 SGTC_1378 2093-0007 4.56 380.0 nM 4.70E-6 2 2.51E-6 0.45
14 SGTC_158 k038-0087 4.55 26.4 µM 5.11E-6 ubiquinone biosynthesis & proteasome 24 2.74E-6 0.02
15 SGTC_662 k832-1615 4.42 104.0 µM 9.05E-6 2 5.03E-6 0.28
16 SGTC_444 curcumin 4.28 90.4 µM 1.60E-5 iron homeostasis 11 9.20E-6 0.15
17 SGTC_1587 estradiol valerate 4.15 56.1 µM 2.76E-5 1 1.63E-5 0.28
18 SGTC_2124 5246320 3.99 200.0 µM 5.31E-5 heme biosynthesis & mitochondrial translocase 27 3.25E-5 0.07
19 SGTC_339 3091-4833 3.94 71.4 µM 6.56E-5 iron homeostasis 15 4.07E-5 0.02
20 SGTC_837 0091-0265 3.90 12.5 µM 7.76E-5 ubiquinone biosynthesis & proteasome 13 4.86E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.510 2.37E-221 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.442 1.11E-159 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.426 8.23E-148 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.409 1.91E-135 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.408 1.10E-134 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.364 1.80E-105 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.360 6.40E-103 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.358 6.18E-102 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.343 6.22E-93 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.339 1.13E-90 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.329 5.67E-85 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.318 1.81E-79 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.292 6.96E-67 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.259 1.50E-52 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.256 2.70E-51 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p