YBL042C / FUI1

High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL042C / FUI1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.84|P-value:1.95E-6 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.61|P-value:1.54E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.38|P-value:6.99E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.54|P-value:1.99E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.47|P-value:8.57E-8 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.06|P-value:5.80E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:4.55|P-value:7.27E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:4.62|P-value:5.25E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:6.94|P-value:1.38E-11 ID:SGTC_382|Compound:3229-0966|FD-Score:3.40|P-value:6.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.33|P-value:8.26E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:9.29|P-value:1.88E-19 ID:SGTC_527|Compound:4476-4215|FD-Score:3.64|P-value:2.85E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.24|P-value:2.73E-7 ID:SGTC_591|Compound:4299-0174|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.36|P-value:7.51E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.00|P-value:7.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.81|P-value:2.24E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.19|P-value:7.07E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.94|P-value:1.23E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.96|P-value:8.60E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.54|P-value:3.95E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.17|P-value:3.62E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.30|P-value:2.15E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:7.12|P-value:3.98E-12 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.65|P-value:1.36E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.71|P-value:3.63E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:4.65|P-value:4.70E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:4.27|P-value:2.43E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.51|P-value:6.96E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:3.64|P-value:2.80E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.90|P-value:1.48E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.11|P-value:5.33E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:6.24|P-value:1.14E-9 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.43|P-value:5.90E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.15|P-value:4.36E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.16|P-value:3.90E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.87|P-value:1.72E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:5.82|P-value:1.26E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.51|P-value:8.71E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.79|P-value:2.49E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:6.30|P-value:7.92E-10 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.44|P-value:1.17E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.50|P-value:9.06E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:7.66|P-value:9.18E-14 ID:SGTC_1637|Compound:st007924|FD-Score:6.32|P-value:7.09E-10 ID:SGTC_1653|Compound:st012112|FD-Score:3.47|P-value:5.16E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.39|P-value:6.62E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.04|P-value:6.15E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.69|P-value:6.97E-11 ID:SGTC_1750|Compound:st081859|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.15|P-value:3.96E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.95|P-value:8.85E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.66|P-value:2.60E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.49|P-value:7.79E-8 ID:SGTC_1943|Compound:st076331|FD-Score:4.76|P-value:2.80E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.56|P-value:3.77E-4 ID:SGTC_2178|Compound:5812956|FD-Score:5.80|P-value:1.39E-8 ID:SGTC_2192|Compound:5915882|FD-Score:5.45|P-value:9.61E-8 ID:SGTC_2238|Compound:6671620|FD-Score:3.51|P-value:4.51E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.35|P-value:7.69E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.10|P-value:4.85E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.20|P-value:6.82E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.80|P-value:1.41E-8 ID:SGTC_2363|Compound:9053361|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.87|P-value:9.63E-9 ID:SGTC_2467|Compound:5474540|FD-Score:3.30|P-value:8.99E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.06|P-value:5.71E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.44|P-value:1.19E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.31|P-value:2.04E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.16|P-value:4.24E-7 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.36|P-value:7.54E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.55|P-value:7.33E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.41|P-value:1.36E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.64|P-value:9.29E-11 ID:SGTC_2821|Compound:7996764|FD-Score:3.93|P-value:9.62E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.99|P-value:7.68E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_2928|Compound:9011484|FD-Score:7.52|P-value:2.53E-13 ID:SGTC_2967|Compound:9089538|FD-Score:3.49|P-value:4.84E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.74|P-value:1.95E-8 ID:SGTC_3009|Compound:9080819|FD-Score:3.99|P-value:7.58E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.28|P-value:5.15E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.35|P-value:7.73E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.95|P-value:4.08E-5 ID:SGTC_3212|Compound:9128307|FD-Score:7.39|P-value:6.34E-13 ID:SGTC_3259|Compound:9138485|FD-Score:-3.45|P-value:2.84E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_3270|Compound:9137563|FD-Score:4.32|P-value:1.94E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.56|P-value:6.98E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.84|P-value:1.95E-6 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.61|P-value:1.54E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.38|P-value:6.99E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.54|P-value:1.99E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.47|P-value:8.57E-8 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.06|P-value:5.80E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:4.55|P-value:7.27E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:4.62|P-value:5.25E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:6.94|P-value:1.38E-11 ID:SGTC_382|Compound:3229-0966|FD-Score:3.40|P-value:6.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.33|P-value:8.26E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:9.29|P-value:1.88E-19 ID:SGTC_527|Compound:4476-4215|FD-Score:3.64|P-value:2.85E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.24|P-value:2.73E-7 ID:SGTC_591|Compound:4299-0174|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.36|P-value:7.51E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.00|P-value:7.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.81|P-value:2.24E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.19|P-value:7.07E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.94|P-value:1.23E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.96|P-value:8.60E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.54|P-value:3.95E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.17|P-value:3.62E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.30|P-value:2.15E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:7.12|P-value:3.98E-12 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.65|P-value:1.36E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.71|P-value:3.63E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:4.65|P-value:4.70E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:4.27|P-value:2.43E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.51|P-value:6.96E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:3.64|P-value:2.80E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.90|P-value:1.48E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.11|P-value:5.33E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:6.24|P-value:1.14E-9 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.43|P-value:5.90E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.15|P-value:4.36E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.16|P-value:3.90E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.87|P-value:1.72E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:5.82|P-value:1.26E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.51|P-value:8.71E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.79|P-value:2.49E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:6.30|P-value:7.92E-10 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.44|P-value:1.17E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.50|P-value:9.06E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:7.66|P-value:9.18E-14 ID:SGTC_1637|Compound:st007924|FD-Score:6.32|P-value:7.09E-10 ID:SGTC_1653|Compound:st012112|FD-Score:3.47|P-value:5.16E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.39|P-value:6.62E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.04|P-value:6.15E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.69|P-value:6.97E-11 ID:SGTC_1750|Compound:st081859|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.15|P-value:3.96E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.95|P-value:8.85E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.66|P-value:2.60E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.49|P-value:7.79E-8 ID:SGTC_1943|Compound:st076331|FD-Score:4.76|P-value:2.80E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.56|P-value:3.77E-4 ID:SGTC_2178|Compound:5812956|FD-Score:5.80|P-value:1.39E-8 ID:SGTC_2192|Compound:5915882|FD-Score:5.45|P-value:9.61E-8 ID:SGTC_2238|Compound:6671620|FD-Score:3.51|P-value:4.51E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.35|P-value:7.69E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.10|P-value:4.85E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.20|P-value:6.82E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.80|P-value:1.41E-8 ID:SGTC_2363|Compound:9053361|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.87|P-value:9.63E-9 ID:SGTC_2467|Compound:5474540|FD-Score:3.30|P-value:8.99E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.06|P-value:5.71E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.44|P-value:1.19E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.31|P-value:2.04E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.16|P-value:4.24E-7 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.36|P-value:7.54E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.55|P-value:7.33E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.41|P-value:1.36E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.64|P-value:9.29E-11 ID:SGTC_2821|Compound:7996764|FD-Score:3.93|P-value:9.62E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.99|P-value:7.68E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_2928|Compound:9011484|FD-Score:7.52|P-value:2.53E-13 ID:SGTC_2967|Compound:9089538|FD-Score:3.49|P-value:4.84E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.74|P-value:1.95E-8 ID:SGTC_3009|Compound:9080819|FD-Score:3.99|P-value:7.58E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.28|P-value:5.15E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.35|P-value:7.73E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.95|P-value:4.08E-5 ID:SGTC_3212|Compound:9128307|FD-Score:7.39|P-value:6.34E-13 ID:SGTC_3259|Compound:9138485|FD-Score:-3.45|P-value:2.84E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.29|P-value:2.24E-5 ID:SGTC_3270|Compound:9137563|FD-Score:4.32|P-value:1.94E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.56|P-value:6.98E-6

Top fitness defect scores for YBL042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_388 3',4'-dichloroisocoumarin 9.29 16.7 µM 1.88E-19 1 7.94E-21
2 SGTC_1486 3970-0793 7.66 4.5 µM 9.18E-14 1 9.32E-15
3 SGTC_2928 9011484 7.52 9.8 µM 2.53E-13 heme biosynthesis & mitochondrial translocase 3 2.76E-14
4 SGTC_3212 9128307 7.39 49.5 µM 6.34E-13 6 7.35E-14
5 SGTC_915 methyl methanesulfonate (MMS) 7.12 110.0 mM 3.98E-12 DNA damage response 6 5.23E-13
6 SGTC_380 3970-0968 6.94 6.0 µM 1.38E-11 2 1.98E-12
7 SGTC_1745 st081495 6.69 74.0 µM 6.97E-11 RNA processing & uracil transport 19 1.12E-11
8 SGTC_2788 5282734 6.64 71.4 µM 9.29E-11 8 1.52E-11
9 SGTC_1637 st007924 6.32 17.4 µM 7.09E-10 4 1.34E-10
10 SGTC_1468 k284-1086 6.30 134.0 µM 7.92E-10 DNA intercalators 4 1.50E-10
11 SGTC_1192 1488-0095 6.24 21.4 µM 1.14E-9 4 2.21E-10
12 SGTC_2462 5162487 5.87 171.8 µM 9.63E-9 3 2.18E-9
13 SGTC_1322 1348-1070 5.82 12.0 µM 1.26E-8 1 2.91E-9
14 SGTC_2178 5812956 5.80 200.0 µM 1.39E-8 1 3.23E-9
15 SGTC_2313 7726885 5.80 200.0 µM 1.41E-8 RPP1 & pyrimidine depletion 9 3.30E-9
16 SGTC_2970 9090938 5.74 41.9 µM 1.95E-8 RNA processing & uracil transport 6 4.65E-9
17 SGTC_961 1252-1571 5.51 372.0 µM 6.96E-8 13 1.82E-8
18 SGTC_1934 st074720 5.49 32.6 µM 7.79E-8 18 2.05E-8
19 SGTC_167 3672-0051 5.47 66.2 µM 8.57E-8 16 2.28E-8
20 SGTC_2192 5915882 5.45 198.5 µM 9.61E-8 RNA processing & uracil transport 18 2.57E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.27E-11 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.102 3.68E-9 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.095 3.07E-8 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.089 2.09E-7 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.89E-7 YCR081W SRB8 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
0.081 2.41E-6 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.079 4.51E-6 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.077 8.63E-6 YNR012W URK1 hom Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
0.076 1.05E-5 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.074 1.64E-5 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.073 2.24E-5 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.072 2.75E-5 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.069 6.59E-5 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.068 7.88E-5 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 9.58E-5 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones