YBL044W_p

Putative protein of unknown function; YBL044W is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL044W / YBL044W

Click on Significant Values for Screen Details ID:SGTC_381|Compound:3461-2219|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.87|P-value:6.16E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.36|P-value:4.26E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.91|P-value:5.26E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:4.07|P-value:2.72E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.87|P-value:7.95E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.85|P-value:5.01E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.71|P-value:2.08E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.80|P-value:1.06E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.30|P-value:6.53E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.89|P-value:5.62E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.23|P-value:6.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.55|P-value:3.28E-6 ID:SGTC_2283|Compound:7944793|FD-Score:4.21|P-value:1.46E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-4.28|P-value:1.46E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.64|P-value:1.89E-4 ID:SGTC_2366|Compound:9070441|FD-Score:7.00|P-value:2.29E-12 ID:SGTC_2368|Compound:9071271|FD-Score:-3.23|P-value:8.16E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.63|P-value:2.02E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.71|P-value:2.11E-6 ID:SGTC_2814|Compound:7977482|FD-Score:-3.59|P-value:2.31E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.86|P-value:7.19E-7 ID:SGTC_2897|Compound:9048598|FD-Score:4.34|P-value:8.39E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.83|P-value:7.15E-5 ID:SGTC_2979|Compound:9012552|FD-Score:3.16|P-value:8.25E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.97|P-value:4.10E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.94|P-value:4.65E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.62|P-value:1.61E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.35|P-value:4.38E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.77|P-value:1.19E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.87|P-value:6.16E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.36|P-value:4.26E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.91|P-value:5.26E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:4.07|P-value:2.72E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.87|P-value:7.95E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.85|P-value:5.01E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.71|P-value:2.08E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.80|P-value:1.06E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.30|P-value:6.53E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.89|P-value:5.62E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.23|P-value:6.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.55|P-value:3.28E-6 ID:SGTC_2283|Compound:7944793|FD-Score:4.21|P-value:1.46E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-4.28|P-value:1.46E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.64|P-value:1.89E-4 ID:SGTC_2366|Compound:9070441|FD-Score:7.00|P-value:2.29E-12 ID:SGTC_2368|Compound:9071271|FD-Score:-3.23|P-value:8.16E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.63|P-value:2.02E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.60|P-value:1.73E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.71|P-value:2.11E-6 ID:SGTC_2814|Compound:7977482|FD-Score:-3.59|P-value:2.31E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.86|P-value:7.19E-7 ID:SGTC_2897|Compound:9048598|FD-Score:4.34|P-value:8.39E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.83|P-value:7.15E-5 ID:SGTC_2979|Compound:9012552|FD-Score:3.16|P-value:8.25E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.97|P-value:4.10E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.94|P-value:4.65E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.62|P-value:1.61E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.35|P-value:4.38E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.77|P-value:1.19E-4

Top fitness defect scores for YBL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2366 9070441 7.00 60.6 µM 2.29E-12 2 1.32E-12
2 SGTC_2880 9042983 4.86 58.4 µM 7.19E-7 fatty acid desaturase (OLE1) 11 5.77E-7
3 SGTC_2282 7944268 4.55 200.0 µM 3.28E-6 RPP1 & pyrimidine depletion 17 2.73E-6
4 SGTC_2897 9048598 4.34 13.0 µM 8.39E-6 8 7.14E-6
5 SGTC_2283 7944793 4.21 200.0 µM 1.46E-5 34 1.26E-5
6 SGTC_781 4335-2806 4.07 94.4 µM 2.72E-5 17 2.38E-5
7 SGTC_2990 9074105 3.97 71.4 µM 4.10E-5 5 3.62E-5
8 SGTC_2992 9074591 3.94 71.4 µM 4.65E-5 16 4.12E-5
9 SGTC_774 k060-0086 3.91 136.0 µM 5.26E-5 19 4.67E-5
10 SGTC_1842 st055362 3.89 61.2 µM 5.62E-5 16 5.00E-5
11 SGTC_432 NS 1619 3.87 61.3 µM 6.16E-5 29 5.49E-5
12 SGTC_2956 9076196 3.83 2.5 µM 7.15E-5 21 6.40E-5
13 SGTC_787 4152-0075 3.80 138.0 µM 8.07E-5 25 7.23E-5
14 SGTC_3192 9110362 3.62 49.5 µM 1.61E-4 mitochondrial processes 15 1.47E-4
15 SGTC_2604 4'-hydroxychalcone 3.60 11.3 µM 1.73E-4 52 1.58E-4
16 SGTC_381 3461-2219 3.58 42.7 µM 1.90E-4 copper-dependent oxidative stress 27 1.74E-4
17 SGTC_689 0833-0039 3.36 98.0 µM 4.26E-4 ergosterol depletion effects on membrane 45 3.96E-4
18 SGTC_3223 9129970 3.35 49.5 µM 4.38E-4 40 4.07E-4
19 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.30 100.0 µM 5.14E-4 46 4.80E-4
20 SGTC_1701 st028638 3.29 40.4 µM 5.27E-4 35 4.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 8.32E-18 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.143 9.59E-17 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.100 5.74E-9 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.099 1.00E-8 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.093 5.92E-8 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.092 8.55E-8 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.089 2.68E-7 YOR273C TPO4 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane
0.088 3.89E-7 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.086 6.22E-7 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.085 7.28E-7 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.085 7.57E-7 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.084 1.16E-6 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.081 2.34E-6 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.080 3.37E-6 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.080 4.14E-6 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol