YBL046W / PSY4

Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL046W / PSY4

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.87|P-value:3.78E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.27|P-value:6.33E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.48|P-value:1.90E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.12|P-value:1.29E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.97|P-value:2.45E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.21|P-value:5.10E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.14|P-value:1.45E-13 ID:SGTC_268|Compound:camptothecin|FD-Score:5.13|P-value:7.96E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.71|P-value:7.46E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:6.01|P-value:4.02E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:4.14|P-value:1.17E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.60|P-value:1.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:6.35|P-value:4.40E-11 ID:SGTC_380|Compound:3970-0968|FD-Score:3.70|P-value:7.76E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.67|P-value:9.20E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:5.29|P-value:3.13E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.68|P-value:8.61E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.73|P-value:6.85E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:5.04|P-value:1.26E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.51|P-value:8.15E-15 ID:SGTC_651|Compound:3253-0966|FD-Score:5.22|P-value:4.65E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:7.00|P-value:4.06E-13 ID:SGTC_788|Compound:1182-0090|FD-Score:6.03|P-value:3.60E-10 ID:SGTC_862|Compound:0452-0056|FD-Score:7.59|P-value:4.38E-15 ID:SGTC_863|Compound:0466-0191|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.61|P-value:1.25E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.14|P-value:1.44E-13 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.14|P-value:1.17E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.28|P-value:4.04E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.97|P-value:1.86E-7 ID:SGTC_1115|Compound:galangin|FD-Score:4.41|P-value:3.31E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.58|P-value:1.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.31|P-value:4.11E-14 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.08|P-value:1.53E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.29|P-value:3.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.04|P-value:1.31E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.51|P-value:1.67E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.13|P-value:6.82E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.51|P-value:1.98E-6 ID:SGTC_1623|Compound:st003709|FD-Score:3.91|P-value:3.17E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.64|P-value:9.93E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.62|P-value:6.70E-12 ID:SGTC_1722|Compound:st034304|FD-Score:3.54|P-value:1.49E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.78|P-value:1.76E-9 ID:SGTC_1754|Compound:st042065|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.23|P-value:7.85E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.91|P-value:7.77E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.47|P-value:2.45E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.48|P-value:2.30E-6 ID:SGTC_1902|Compound:st060212|FD-Score:4.60|P-value:1.31E-6 ID:SGTC_1908|Compound:st060353|FD-Score:4.98|P-value:1.79E-7 ID:SGTC_2006|Compound:4011487|FD-Score:3.16|P-value:6.17E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.15|P-value:1.11E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.74|P-value:6.67E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.05|P-value:9.21E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.08|P-value:8.17E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.40|P-value:2.56E-4 ID:SGTC_2367|Compound:9070478|FD-Score:5.12|P-value:8.52E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.20|P-value:1.17E-10 ID:SGTC_2414|Compound:st077232|FD-Score:4.41|P-value:3.34E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.69|P-value:8.37E-7 ID:SGTC_2479|Compound:5617353|FD-Score:6.89|P-value:9.54E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:3.99|P-value:2.22E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:2.95E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.46|P-value:2.62E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.12|P-value:7.17E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.42|P-value:2.33E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.20|P-value:8.80E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.13|P-value:6.87E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.89|P-value:3.43E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.14|P-value:6.70E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.44|P-value:2.18E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.40|P-value:3.47E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:3.87|P-value:3.78E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.27|P-value:6.33E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.48|P-value:1.90E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.12|P-value:1.29E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.97|P-value:2.45E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.21|P-value:5.10E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.14|P-value:1.45E-13 ID:SGTC_268|Compound:camptothecin|FD-Score:5.13|P-value:7.96E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.71|P-value:7.46E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:6.01|P-value:4.02E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:4.14|P-value:1.17E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.60|P-value:1.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:6.35|P-value:4.40E-11 ID:SGTC_380|Compound:3970-0968|FD-Score:3.70|P-value:7.76E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.67|P-value:9.20E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:5.29|P-value:3.13E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.68|P-value:8.61E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.73|P-value:6.85E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:5.04|P-value:1.26E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.51|P-value:8.15E-15 ID:SGTC_651|Compound:3253-0966|FD-Score:5.22|P-value:4.65E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:7.00|P-value:4.06E-13 ID:SGTC_788|Compound:1182-0090|FD-Score:6.03|P-value:3.60E-10 ID:SGTC_862|Compound:0452-0056|FD-Score:7.59|P-value:4.38E-15 ID:SGTC_863|Compound:0466-0191|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.61|P-value:1.25E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.14|P-value:1.44E-13 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.14|P-value:1.17E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.28|P-value:4.04E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.97|P-value:1.86E-7 ID:SGTC_1115|Compound:galangin|FD-Score:4.41|P-value:3.31E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.25|P-value:4.55E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.58|P-value:1.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.31|P-value:4.11E-14 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.08|P-value:1.53E-5 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.29|P-value:3.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.04|P-value:1.31E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.51|P-value:1.67E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.13|P-value:6.82E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.37|P-value:2.85E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.51|P-value:1.98E-6 ID:SGTC_1623|Compound:st003709|FD-Score:3.91|P-value:3.17E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.64|P-value:9.93E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.62|P-value:6.70E-12 ID:SGTC_1722|Compound:st034304|FD-Score:3.54|P-value:1.49E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.78|P-value:1.76E-9 ID:SGTC_1754|Compound:st042065|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.23|P-value:7.85E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.91|P-value:7.77E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.47|P-value:2.45E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.48|P-value:2.30E-6 ID:SGTC_1902|Compound:st060212|FD-Score:4.60|P-value:1.31E-6 ID:SGTC_1908|Compound:st060353|FD-Score:4.98|P-value:1.79E-7 ID:SGTC_2006|Compound:4011487|FD-Score:3.16|P-value:6.17E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.15|P-value:1.11E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.74|P-value:6.67E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.05|P-value:9.21E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.95|P-value:2.68E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.08|P-value:8.17E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.40|P-value:2.56E-4 ID:SGTC_2367|Compound:9070478|FD-Score:5.12|P-value:8.52E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.20|P-value:1.17E-10 ID:SGTC_2414|Compound:st077232|FD-Score:4.41|P-value:3.34E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.69|P-value:8.37E-7 ID:SGTC_2479|Compound:5617353|FD-Score:6.89|P-value:9.54E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:3.99|P-value:2.22E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:2.95E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.46|P-value:2.62E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.12|P-value:7.17E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.42|P-value:2.33E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.20|P-value:8.80E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.13|P-value:6.87E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.89|P-value:3.43E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.14|P-value:6.70E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.44|P-value:2.18E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.40|P-value:3.47E-6

Top fitness defect scores for YBL046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_862 0452-0056 7.59 10.2 µM 4.38E-15 azole & statin 10 1.61E-14
2 SGTC_637 1181-0519 7.51 7.3 µM 8.15E-15 fatty acid desaturase (OLE1) 33 2.92E-14
3 SGTC_1317 1273-0028 7.31 910.0 nM 4.11E-14 azole & statin 21 1.38E-13
4 SGTC_1019 4262-0212 7.14 3.4 µM 1.44E-13 ergosterol depletion effects on membrane 16 4.57E-13
5 SGTC_221 trifluoperazine 7.14 10.3 µM 1.45E-13 NEO1-PIK1 100 4.60E-13
6 SGTC_690 glyoxal 7.00 20.3 µM 4.06E-13 35 1.24E-12
7 SGTC_2479 5617353 6.89 43.9 µM 9.54E-13 2 2.80E-12
8 SGTC_1712 st032288 6.62 53.4 µM 6.70E-12 calcium & mitochondrial duress 62 1.82E-11
9 SGTC_363 0455-0021 6.35 3.1 µM 4.40E-11 azole & statin 28 1.10E-10
10 SGTC_788 1182-0090 6.03 188.0 µM 3.60E-10 endomembrane recycling 32 8.26E-10
11 SGTC_304 1310-0298 6.01 97.0 µM 4.02E-10 cell wall 19 9.18E-10
12 SGTC_1800 st050079 5.91 29.1 µM 7.77E-10 NEO1-PIK1 41 1.73E-9
13 SGTC_409 arachidonic acid 5.29 100.0 µM 3.13E-8 9 5.98E-8
14 SGTC_651 3253-0966 5.22 34.4 µM 4.65E-8 calcium & mitochondrial duress 11 8.73E-8
15 SGTC_268 camptothecin 5.13 39.6 µM 7.96E-8 DNA damage response 43 1.46E-7
16 SGTC_2367 9070478 5.12 135.4 µM 8.52E-8 cell wall 17 1.56E-7
17 SGTC_568 1193-0097 5.04 7.5 µM 1.26E-7 ERAD & cell cycle 84 2.28E-7
18 SGTC_1495 4469-0029 5.04 237.0 µM 1.31E-7 68 2.36E-7
19 SGTC_1908 st060353 4.98 56.5 µM 1.79E-7 RPP1 & pyrimidine depletion 20 3.18E-7
20 SGTC_1114 scopoletin 4.97 1.7 µM 1.86E-7 11 3.30E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.355 5.13E-100 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.307 5.56E-74 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.298 1.21E-69 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.297 3.00E-69 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.294 9.74E-68 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.294 1.03E-67 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.282 2.55E-62 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.274 1.56E-58 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.265 4.76E-55 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.257 7.95E-52 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.256 3.41E-51 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.254 1.51E-50 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.252 1.44E-49 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.250 4.81E-49 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.248 3.42E-48 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family